Effects of Rapid-Resisted Exercise and Bright Light Therapy on Adults with TBI

主要结果 由于我们最近才开始收集数据，因此尚未报告结果。 拟议工作进程 指导这项工作的首要假设是，通过脊髓通路刺激大脑，在长时间内快速重复肌肉激活，将导致大脑区域之间连接程度的变化。 不幸的是，我们没有时间分辨率来评估皮层反应时间的变化，但这可以通过认知和运动反应速度的变化来推断，假设这些发生了。如果反应速度确实增加，未来的研究将使用更高的时间分辨率的成像技术。 我们在这里包括复杂的平衡评估以及双重任务评估范式，我们预计这将是特别敏感的措施，在这一人群中。我们在其他NIH TBI方案中纳入了类似的措施，包括RMD筛查方案（Chan：PI）和慢性TBI纵向队列研究（Chan：PI）以及潜在的Breecher研究（Grafman：PI）。 这将产生一个广泛的患者与平衡和脑成像数据，将使我们能够破译一些潜在的机制，平衡障碍，在这个群体。 由此，可以启动针对平衡障碍的靶向临床试验。Cristiane Zampieri-Gallagher博士很可能会在我的指导下领导这些未来的调查。 项目影响声明 该项目有可能有助于我们对脑损伤的基本理解，并导致新的治疗方法，以提高运动和/或心理健康，促进TBI患者的神经恢复。提出了一种新的干预措施，在其他相关疾病人群中已显示出一定程度的疗效。使用快速椭圆训练是基于最近的证据，运动在神经修复和多个大脑子系统（运动，感觉，认知，情感等）功能恢复中的基本作用。该项目也与CNRM的意图和使命密切相关，CNRM的意图和使命是在联邦机构之间建立桥梁，以推进创伤性脑损伤的科学研究，特别关注神经可塑性和损伤前功能恢复的潜力。

Major Findings There are no results to report as yet since we have only recently started data collection. Proposed Course of Work The overarching hypothesis guiding this work is that stimulating the brain via the spinal pathways with fast repetitive muscle activation over a prolonged period will lead to changes in the degree of connectivity across brain regions. Unfortunately, we will not have the temporal resolution to evaluate changes in timing of the cortical responses, but this may be inferred by the changes in the cognitive and motor response speeds, assuming these occur. If response speed does increase, future studies using imaging techniques with greater temporal resolution would be indicated. We are including sophisticated balance assessments as well as dual task assessment paradigms here that we anticipate will be particularly sensitive measures in this population. We are including similar measures in other NIH TBI protocols including the RMD Screening Protocol (Chan: PI) and the chronic TBI Longitudinal Cohort Study (Chan: PI) and potentially the Breecher Study (Grafman: PI). This will yield a wide-range of patients with balance and brain imaging data that will enable us to decipher some of the potential mechanisms for balance disorders in this population. From this, targeted clinical trials to specifically address balance disorders can be initiated. Dr. Cristiane Zampieri-Gallagher will most likely lead these future investigations under my mentorship. Project Impact Statement This project has the potential to contribute to our fundamental understanding of brain injury as well as lead to new treatments to enhance motor and/or psychological well-being and promote neural recovery in those with TBI. A novel intervention is proposed that has been shown some level of efficacy in other populations with related disorders. The use of fast speed elliptical training is based on recent evidence on the fundamental role of exercise in neural repair and recovery of function across multiple brain subsystems (motor, sensory, cognitive, emotional, etc.). This project also has strong relevance to the intent and mission of the CNRM which is to create bridges across federal institutional efforts to advance the scientific study of traumatic brain injury, with a specific interest in the potential for neural plasticity and recovery of pre-injury functioning.