Effects of Rapid-Resisted Exercise and Bright Light Therapy on Adults with TBI

主要发现 我们已经完成了所有的数据收集，并发表了临床研究结果，这些结果表明，锻炼后自愿和非自愿平衡反应时的速度发生了显着变化。我们已经完成了对fMRI任务的分析，发现锻炼计划后，在这一人群中服务于平衡的大脑区域发生了显着变化，这些变化与临床改善相关。我们目前正在准备一份关于这些结果的手稿，以供提交。 项目影响说明书 该项目有助于我们对脑损伤的基本了解，并可能带来新的治疗方法，以增强脑外伤患者的运动和/或心理健康，并促进神经恢复。使用快速椭圆训练是基于最近的证据，即运动在神经修复和大脑多个子系统(运动、感觉、认知、情绪等)功能恢复中的基础作用。该项目还与CNRM的意图和使命有很强的相关性，即建立跨联邦机构努力的桥梁，以推进创伤性脑损伤的科学研究，特别关注神经可塑性和损伤前功能恢复的潜力。 这一试点项目导致了一项随机临床试验的设计，该试验将这种更适度的运动与目前正在进行的针对脑外伤患者的更高强度的有氧运动进行比较。

Major Findings We have completed all data collection and have published the clinical findings which demonstrated significant changes after exercise on the speed of voluntary and involuntary balance reaction time. We have completed analyses of the fMRI task and found that there were significant changes after the exercise program in the brain regions that sub serve balance in this population and these changes were correlated with clinical improvements. We are currently preparing a manuscript on these results for submission. Project Impact Statement This project has contributed to our fundamental understanding of brain injury and may lead to new treatments to enhance motor and/or psychological well-being and promote neural recovery in those with TBI. The use of fast speed elliptical training is based on recent evidence on the fundamental role of exercise in neural repair and recovery of function across multiple brain subsystems (motor, sensory, cognitive, emotional, etc.). This project also has strong relevance to the intent and mission of the CNRM which is to create bridges across federal institutional efforts to advance the scientific study of traumatic brain injury, with a specific interest in the potential for neural plasticity and recovery of pre-injury functioning. This pilot project has lead to the design of a randomized clinical trial comparing this more moderate exercise to higher intensity aerobic exercise in individuals with TBI that is currently underway.