TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 A.具体目标 我们的MeTRC计划的这一组成部分的目标是 建立一个蛋白质组学核心设施，这将服务于广泛的 研究社区，并将大大提高翻译和 Meharry医学院的临床研究。五项目标包括 获取用于质谱分析的LC-MS / MS系统， 蛋白质样品，并建立适当的基础设施， 蛋白质组学教育和推广我们的教师和学员。 这项活动旨在为研究人员和学员提供能力， 以获得关于其感兴趣的蛋白质的关键信息， 在基础、临床和翻译环境中推进蛋白质发现。 拟议活动的具体目标是：（1）制定一项 蛋白质组学核心设施，以支持Meharry的临床和 翻译研究活动;（2）发展合作 以及梅哈里医学院内外的合作伙伴关系， 加速临床和转化研究， 依赖于最先进的蛋白质组学策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A. Specific Aims The objective of this component of our MeTRC Program is to establish a Proteomics Core facility, which will serve the broad research community and will significantly enhance translational and clinical research at Meharry Medical College. The goals include acquiring an LC-MS / MS system for mass spectrometry analysis of protein samples, and to establish the appropriate infrastructure for proteomics education and outreach among our faculty and trainees. This activity is aimed to provide researchers and trainees the ability to obtain critical information about their proteins of interest and to advance protein discovery in basic, clinical and translational settings. The specific aims of the proposed activity are: (1) To develop a Proteomics Core Facility to support Meharry's clinical and translational research activities; and (2) To develop collaborations and partnerships inside and outside of Meharry Medical College that accelerate clinical and translational research, with the common link being the reliance on state-of-the-art proteomics strategies.