DREW RCMI TRANSLATIONAL RESEARCH NETWORK

DREW RCMI 翻译研究网络

• 批准号: 8359912
• 负责人: Keith C Norris
• 金额: $ 349.44万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359912
• 关键词: Academia; Address; Affect; Area; Behavioral; Biomedical Research; Biometry; Cardiovascular Diseases; Cause of Death; Clinical; Clinical Ethics; Clinical Research; Communities; Data; Data Collection; Development; Diagnosis; Disadvantaged; Disease; Educational Activities; Fostering; Funding; Future; Grant; Health; Incentives; Institution; Interdisciplinary Study; Knowledge; Link; Minority; Movement; National Center for Research Resources; Outcome; Patients; Population; Prevention; Principal Investigator; Provider; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Scientific Advances and Accomplishments; Scientist; Site; Solid; Source; Technology; Translational Research; Underrepresented Minority; United States National Institutes of Health; Universities; Work; clinical efficacy; cost; design; efficacy research; health disparity; improved; innovation; member; multidisciplinary; novel; public health priorities; systems research; translational approach; translational medicine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by the applicant): On behalf of the 18 Research Centers in Minority Institutions (RCMI), Charles R. Drew University submits this application to design and implement the RCMI Translational Research Network (RTRN or Network). The successful translation of research findings to address health disparities is limited by growing barriers between clinical and basic researchers. RTRN will foster collaborative translational research with a particular focus on key health disparity disease areas; establish a Data Technology Coordinating Center (DTCC) at Jackson State University (JSU) and provide innovative opportunities to share educational, research, and community resources. The Network seeks to transform institutional research culture across the Network members by promoting institutional incentives (e.g., promotion, tenure) for research efforts that produce tangible advances in health outcomes. To leverage the unique strengths of the RCMI community (7450 NIH funded projects) and achieve previously unrealized research synergies, RTRN will facilitate interactions between clinical and basic scientists working within different disease areas, create bridges between academia and community to accelerate the clinical efficacy of research advances, and foster the development of future leaders in translational medicine with a sensitivity to health areas disproportionately affecting disadvantaged populations. RTRN will initiate a multidisciplinary "proof-of-concept" project addressing cardiovascular disease, the leading cause of death in the nation. The Network specific aims include: Specific Aim 1: Establish the Network. To integrate clinical, biomedical and behavioral researchers with providers and community leaders into novel geographic and ethnically diverse research partnerships aimed at improving patient outcomes identified as key national public health priorities; Specific Aim 2: Generate Translational Research. To create a system of research clusters which links collaborating members within cyber workspaces to promote intellectual exchange, generate innovative inter- and multi-disciplinary research, and facilitate the movement of scientific advances throughout the translational research spectrum; Specific Aim 3: Conduct Multi-site Research. To develop a robust multidisciplinary research component that facilitates the conduct of multi-site studies and encourages innovative translational approaches to basic mechanisms, prevention, diagnosis, and treatment of diseases that disproportionately affect minority and underserved communities; and Specific Aim 4: Implement the Data Technology and Coordinating Center (DTCC). To implement a DTCC grounded in solid research design, biostatistics, clinical ethics, regulatory knowledge and data collection/management/analysis to provide coordinated support for each of the three major Network platforms-clinical and biomedical research and educational activities.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 描述（由申请人提供）：查尔斯·德鲁大学代表 18 个少数族裔机构研究中心 (RCMI) 提交此申请，以设计和实施 RCMI 转化研究网络（RTRN 或网络）。由于临床和基础研究人员之间的障碍越来越大，成功地将研究成果转化为解决健康差异的方法受到限制。 RTRN 将促进合作转化研究，特别关注关键的健康差异疾病领域；在杰克逊州立大学 (JSU) 建立数据技术协调中心 (DTCC)，并提供共享教育、研究和社区资源的创新机会。该网络旨在通过促进对在健康成果方面产生切实进展的研究工作的机构激励（例如晋升、终身教职）来转变网络成员的机构研究文化。为了利用 RCMI 社区（7450 个 NIH 资助的项目）的独特优势并实现以前未实现的研究协同效应，RTRN 将促进不同疾病领域的临床和基础科学家之间的互动，在学术界和社区之间建立桥梁，以加速研究进展的临床功效，并培养转化医学未来领导者的发展，他们对对弱势群体影响更大的健康领域保持敏感 人口。 RTRN 将启动一个多学科“概念验证”项目，解决心血管疾病这一美国首要死因。该网络的具体目标包括： 具体目标 1：建立网络。将临床、生物医学和行为研究人员与提供者和社区领导者整合成新颖的地理和种族多元化研究伙伴关系，旨在改善被确定为国家关键公共卫生优先事项的患者治疗结果； 具体目标 2：开展转化研究。创建一个研究集群系统，将网络工作空间内的合作成员联系起来，以促进知识交流，产生创新的跨学科和多学科研究，并促进整个转化研究领域的科学进步； 具体目标 3：进行多地点研究。开发一个强大的多学科研究组成部分，促进多地点研究的进行，并鼓励对对少数群体和服务不足社区造成不成比例影响的疾病的基本机制、预防、诊断和治疗采用创新转化方法；和 具体目标 4：建立数据技术和协调中心 (DTCC)。实施以扎实的研究设计、生物统计学、临床伦理学、监管知识和数据收集/管理/分析为基础的 DTCC，为三大网络平台（临床和生物医学研究和教育活动）提供协调支持。