DREW RCMI TRANSLATIONAL RESEARCH NETWORK

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 描述(由申请人提供)：查尔斯·R·德鲁大学代表18个少数民族院校研究中心(RCMI)提交本申请，以设计和实施RCMI翻译研究网络(RTRN或Network)。临床研究人员和基础研究人员之间日益增长的障碍限制了成功地将研究成果转化为解决健康差距的方法。RTRN将促进合作的转化研究，特别关注关键的健康差距疾病领域；在杰克逊州立大学(JSU)建立数据技术协调中心(DTCC)，并提供分享教育、研究和社区资源的创新机会。该网络寻求改变整个网络成员的机构研究文化，促进对在健康成果方面取得切实进展的研究工作的体制激励(例如，晋升、终身教职)。为了利用RCMI社区的独特优势(NIH资助的7450个项目)并实现以前未实现的研究协同效应，RTRN将促进在不同疾病领域工作的临床和基础科学家之间的互动，在学术界和社区之间建立桥梁，以加快研究进展的临床疗效，并促进转化医学未来领导者的发展，使其对影响弱势群体的健康领域具有不成比例的敏感性。RTRN将启动一个多学科的“概念验证”项目，以应对心血管疾病，这是美国主要的死亡原因。网络的具体目标包括： 具体目标1：建立网络。将临床、生物医学和行为研究人员与提供者和社区领袖整合到新的地域和种族多样化的研究伙伴关系中，旨在改善被确定为关键国家公共卫生优先事项的患者结果； 具体目标2：生成翻译研究。创建一个研究集群系统，将网络工作空间内的合作成员联系起来，以促进智力交流，产生创新的跨学科和多学科研究，并促进科学进步在整个转化研究领域的流动； 具体目标3：开展多点调研。开发一个强有力的多学科研究部分，促进进行多地点研究，并鼓励对影响少数群体和服务不足的社区的疾病的基本机制、预防、诊断和治疗采取创新的翻译方法；以及 具体目标4：实施数据技术和协调中心。实施以扎实的研究设计、生物统计学、临床伦理、监管知识和数据收集/管理/分析为基础的DTCC，为三大网络平台-临床和生物医学研究和教育活动-提供协调支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by the applicant): On behalf of the 18 Research Centers in Minority Institutions (RCMI), Charles R. Drew University submits this application to design and implement the RCMI Translational Research Network (RTRN or Network). The successful translation of research findings to address health disparities is limited by growing barriers between clinical and basic researchers. RTRN will foster collaborative translational research with a particular focus on key health disparity disease areas; establish a Data Technology Coordinating Center (DTCC) at Jackson State University (JSU) and provide innovative opportunities to share educational, research, and community resources. The Network seeks to transform institutional research culture across the Network members by promoting institutional incentives (e.g., promotion, tenure) for research efforts that produce tangible advances in health outcomes. To leverage the unique strengths of the RCMI community (7450 NIH funded projects) and achieve previously unrealized research synergies, RTRN will facilitate interactions between clinical and basic scientists working within different disease areas, create bridges between academia and community to accelerate the clinical efficacy of research advances, and foster the development of future leaders in translational medicine with a sensitivity to health areas disproportionately affecting disadvantaged populations. RTRN will initiate a multidisciplinary "proof-of-concept" project addressing cardiovascular disease, the leading cause of death in the nation. The Network specific aims include: Specific Aim 1: Establish the Network. To integrate clinical, biomedical and behavioral researchers with providers and community leaders into novel geographic and ethnically diverse research partnerships aimed at improving patient outcomes identified as key national public health priorities; Specific Aim 2: Generate Translational Research. To create a system of research clusters which links collaborating members within cyber workspaces to promote intellectual exchange, generate innovative inter- and multi-disciplinary research, and facilitate the movement of scientific advances throughout the translational research spectrum; Specific Aim 3: Conduct Multi-site Research. To develop a robust multidisciplinary research component that facilitates the conduct of multi-site studies and encourages innovative translational approaches to basic mechanisms, prevention, diagnosis, and treatment of diseases that disproportionately affect minority and underserved communities; and Specific Aim 4: Implement the Data Technology and Coordinating Center (DTCC). To implement a DTCC grounded in solid research design, biostatistics, clinical ethics, regulatory knowledge and data collection/management/analysis to provide coordinated support for each of the three major Network platforms-clinical and biomedical research and educational activities.