Genetics 2012: Model Organism to Human Cancer

遗传学 2012：人类癌症模型生物

• 批准号: 8319996
• 负责人: PAUL Warren STERNBERG
• 金额: $ 1.25万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-07 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319996
• 关键词: Age; Americas; Animal Model; Biological Models; Cancer Biology; Collaborations; Communication; Communities; Complex; Development; Disabled Persons; Disease; District of Columbia; Educational process of instructing; Epigenetic Process; Evolution; Fees; Foundations; Future; Genetic; Genomics; Goals; Housing; Human; Human Biology; Knowledge; Learning; Malignant Neoplasms; Medical; Medicine; Mus; Mutation; Organism; Pathology; Patients; Phylogeny; Physiology; Postdoctoral Fellow; Process; Research; Research Personnel; Scientist; Site; Societies; Source; Staging; Structure; Students; Study models; Transcriptional Regulation; Underrepresented Minority; United States National Institutes of Health; Woman; Work; Yeasts; Zebrafish; abstracting; anticancer research; base; cancer genetics; cancer genome; cancer prevention; cancer therapy; career; catalyst; cell growth; cost; design; fly; forging; genome sequencing; genome wide association study; handicapping condition; human disease; human tissue; interest; meetings; novel strategies; prevent; symposium; trait

DESCRIPTION (provided by applicant): This is an application for support of a conference sponsored by the Genetics Society of America (GSA) entitled "Model Organisms to Human Biology: Cancer Genetics", to be held in Washington, DC on June 17-20, 2012. The GSA believes that in this age it is important to convene a meeting that brings together investigators who study model organisms with investigators who study important problems in human biology and disease. This combination promotes a dynamic forum for the exchange of results and ideas between scientists who do not normally interact. Research on model organisms has provided the foundation for our modern-day understanding of human biology, ranging from elucidating the mechanisms for transcriptional regulation to the discoveries that provided the basis for genome-wide association studies of complex human traits. Moreover, these studies, along with more recent cancer genome sequencing projects, have revealed the remarkable extent to which organisms are highly conserved for most fundamental aspects of cellular growth, and how model organism research is directly relevant to understanding human tissue development, physiology, and pathology. However, we still need to learn how best to apply model organisms across the entire spectrum of phylogeny to aspects of cancer biology for which evolution has suited them. These challenges require active discussion among biologists who normally move in different circles. We believe this meeting fills a significant gap in what is available to the scientific community. We also believe that this meeting can act as a catalyst for the type of interdisciplinary initiatives that the NIH encourages and that many see as a source of future advances in cancer biology and medicine. Each session will include two invited speakers (who also serve as session co-chairs) divided between those with a primarily model organism focus or a human/mammalian focus. In addition, four shorter talks will be chosen from the submitted abstracts, to provide opportunities younger investigators to present their work and to enable inclusion of late-breaking stories of special interest. Finally, there will be three keynote talks y world-renowned scientists (Bert Vogelstein, Eric Lander, and Angelika Amon). The meeting is expected to attract approximately 500 people. It will be held at the Omni Shoreham in Washington, DC. All meeting attendees, except local scientists, will be housed on-site and will take most meals together, to stimulate maximal interaction among them. The hotel is accessible to the handicapped and efforts have been made to encourage participation of women and under-represented minorities. The fee structure for the meeting is designed to encourage participation of young scientists. PUBLIC HEALTH RELEVANCE: Progress in understanding human disease and in developing treatments often comes from developing more easily studied model organisms (e.g., yeast, worms, flies, zebrafish, mouse). Genomics has taught us that many important disease processes take place in a much wider group of model organisms than was previously known. This meeting will catalyze scientific exchange and new collaborations between cancer biologists and model organism biologists, which will accelerate progress in understanding the fundamental biology of cancer, and provide the basis for novel approaches to cancer prevention and treatment.

描述（由申请人提供）：这是美国遗传学会 (GSA) 主办的题为“人类生物学模型生物：癌症遗传学”会议的支持申请，该会议将于 2012 年 6 月 17 日至 20 日在华盛顿特区举行。GSA 认为，在这个时代，召开一次会议非常重要，该会议将研究模型生物的研究人员与研究人类生物学和疾病重要问题的研究人员聚集在一起。这种结合促进了通常不互动的科学家之间交流结果和想法的动态论坛。对模式生物的研究为我们现代理解人类生物学奠定了基础，从阐明转录调控机制到为复杂人类特征的全基因组关联研究提供基础的发现。此外，这些研究以及最近的癌症基因组测序项目揭示了生物体在细胞生长的最基本方面高度保守的显着程度，以及模型生物体研究如何与理解人体组织发育、生理学和病理学直接相关。然而，我们仍然需要学习如何最好地将整个系统发育谱中的模式生物应用到进化适合它们的癌症生物学方面。这些挑战需要通常在不同圈子里活动的生物学家之间进行积极讨论。我们相信这次会议填补了科学界现有的重大空白。我们还相信，这次会议可以成为 NIH 鼓励的跨学科举措的催化剂，许多人将其视为癌症生物学和医学未来进步的源泉。每场会议将包括两名受邀演讲者（他们也担任会议联合主席），主要关注模型生物或人类/哺乳动物。此外，将从提交的摘要中选择四个较短的演讲，为年轻的研究人员提供展示其工作的机会，并纳入特别感兴趣的最新报道。最后，世界知名科学家（Bert Vogelstein、Eric Lander 和 Angelika Amon）将进行三场主题演讲。此次会议预计将吸引约500人参加。它将在华盛顿特区的 Omni Shoreham 举行。除当地科学家外，所有与会者都将被安置在现场，并且大部分餐点将一起进餐，以激发他们之间最大程度的互动。该酒店适合残疾人士入住，并努力鼓励妇女和代表性不足的少数族裔的参与。会议的费用结构旨在鼓励年轻科学家的参与。 公共卫生相关性：了解人类疾病和开发治疗方法的进展通常来自开发更容易研究的模型生物（例如酵母、蠕虫、苍蝇、斑马鱼、小鼠）。基因组学告诉我们，许多重要的疾病过程发生在比以前已知的更广泛的模式生物群体中。这次会议将促进癌症生物学家和模式生物生物学家之间的科学交流和新的合作，这将加速对癌症基础生物学的理解，并为癌症预防和治疗的新方法提供基础。