Childhood Interstitial & Diffuse Lung Disease Scientific Conference
童年插页式
基本信息
- 批准号:8319294
- 负责人:
- 金额:$ 2.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-06-01 至 2013-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAdvocateAffectBasic ScienceBiologicalBiological MarkersBiologyBiomedical EngineeringBiotechnologyCaliforniaChildChildhoodChronic Obstructive Airway DiseaseClinicalDevelopmentDevelopmental BiologyDiffuseDisabled PersonsDisciplineDiseaseEducational workshopEmerging TechnologiesEpigenetic ProcessFamilyFunctional disorderFundingFutureGenomicsGenotypeGlycogen Storage DiseaseGrowthHamman-Rich syndromeHyperplasiaIndividualInnovative TherapyInterstitial Lung DiseasesKnowledgeLifeLungLung diseasesMedicineMolecularMorbidity - disease rateMutationNatural regenerationNeonatologyNeuroendocrine CellParentsParticipantPathogenesisPathway interactionsPatientsPredictive FactorPublic HealthRare DiseasesResearch PersonnelScienceScientistTherapeuticUnderrepresented MinorityWorkabstractingbasecareerclinical phenotypeeffective therapyevidence baseinfancyinterdisciplinary approachinterstitiallung developmentmeetingsmolecular phenotypemultidisciplinarynovelnovel strategiespatient advocacy grouppatient populationpostersprogramsrespiratorystem cell biologysurfactantsymposiumtherapeutic target
项目摘要
DESCRIPTION (provided by applicant): Children with childhood diffuse and interstitial lung diseases (chILD) are afflicted with rare, life-threatening, high-morbidity disorders that are poorl understood, under-recognized, and have no known evidence-based therapy. Adult ILD paradigms do not generally apply to chILD entities, which include recently-described disorders such as surfactant dysfunction mutations (SDM), Pulmonary Interstitial Glycogenosis (PIG), and Neuroendocrine Cell Hyperplasia of Infancy (NEHI). However, many of these rare disorders hold clues to understanding normal lung biology, and may unravel aspects of more common diseases. Rare disorders have limited patient populations, requiring novel and interdisciplinary approaches to define clinical phenotypes, genotypes, molecular pathogenesis, predictive factors, biomarkers, and therapeutic targets. Breakthroughs in other rare diseases have recently been catalyzed by the efforts of multidisciplinary teams spurred on by passionate patient advocacy groups. There has not been an interdisciplinary scientific meeting focused on these entities in over five years. This workshop will bring together leaders from clinical, basic science and biotechnology fields, together with chILD family advocates, to promote novel cross-cutting approaches to promote scientific breakthroughs for these clinically vexing disorders. The conference will take place in the summer of 2012 in La Jolla, CA. The objectives of the conference are to: 1) showcase cutting-edge scientific knowledge regarding lung biology relevant to childhood diffuse and interstitial lung disease, including lung development, cellular programming, remodeling and regeneration, 2) promote and encourage young scientists, underrepresented minorities, and persons with disabilities to continue their work in this field and
to pursue careers in science, 3) review emerging technologies that will drive breakthroughs for these rare disorders, and 4) promote novel interactions among the fields of developmental biology, stem cell biology, respiratory medicine, neonatology, genomics, epigenetics and bioengineering, that will ultimately facilitate development of innovative and effective therapies. The conference will bring together leaders and future leaders from these disciplines to address core questions surrounding lung growth, molecular pathogenesis of chILD disorders, and application of emerging technologies for molecular phenotyping and therapeutic discovery. The workshop will provide attendees with a look beyond current state of the art and a pathway to the future.
描述(由申请人提供):患有儿童弥漫性和间质性肺病(chILD)的儿童患有罕见的、危及生命的、高发病率的疾病,这些疾病缺乏了解、认识不足,并且没有已知的循证治疗。成人ILD范例通常不适用于儿童ILD实体,包括最近描述的疾病,如表面活性物质功能障碍突变(SDM)、肺间质糖原累积症(PIG)和婴儿神经内分泌细胞增生(NEHI)。然而,这些罕见疾病中的许多都有了解正常肺生物学的线索,并可能揭示更常见疾病的某些方面。罕见疾病的患者人群有限,需要新的跨学科方法来定义临床表型、基因型、分子发病机制、预测因素、生物标志物和治疗靶点。最近,在热情的患者倡导团体的推动下,多学科团队的努力促进了其他罕见疾病的突破。五年多来没有召开过一次以这些实体为重点的跨学科科学会议。本次研讨会将汇集来自临床,基础科学和生物技术领域的领导者,以及儿童家庭倡导者,以促进新的跨领域方法,以促进这些临床上令人烦恼的疾病的科学突破。会议将于2012年夏天在加利福尼亚州的拉霍亚举行。会议的目标是:1)展示与儿童弥漫性和间质性肺病相关的肺生物学方面的前沿科学知识,包括肺发育,细胞编程,重塑和再生,2)促进和鼓励年轻科学家,代表性不足的少数民族和残疾人继续他们在这一领域的工作,
追求科学事业,3)审查新兴技术,将推动这些罕见疾病的突破,和4)促进发展生物学,干细胞生物学,呼吸医学,呼吸病学,基因组学,表观遗传学和生物工程领域之间的新的相互作用,这将最终促进创新和有效疗法的发展。会议将汇集来自这些学科的领导者和未来的领导者,以解决围绕肺生长,儿童疾病的分子发病机制以及新兴技术在分子表型和治疗发现中的应用的核心问题。研讨会将为与会者提供超越当前最先进水平的视野和通往未来的途径。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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James S. Hagood其他文献
Cooperative signaling between integrins and growth factor receptors in fibrosis
- DOI:
10.1007/s00109-020-02026-2 - 发表时间:
2021-01-03 - 期刊:
- 影响因子:4.200
- 作者:
Horacio Maldonado;James S. Hagood - 通讯作者:
James S. Hagood
James S. Hagood的其他文献
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{{ truncateString('James S. Hagood', 18)}}的其他基金
KULMAP: Human Kidney, urinary tract and lung mapping center
KULMAP:人类肾脏、泌尿道和肺部绘图中心
- 批准号:
9987373 - 财政年份:2019
- 资助金额:
$ 2.3万 - 项目类别:
KULMAP: Human Kidney, urinary tract and lung mapping center
KULMAP:人类肾脏、泌尿道和肺部绘图中心
- 批准号:
10413576 - 财政年份:2018
- 资助金额:
$ 2.3万 - 项目类别:
KULMAP: Human Kidney, urinary tract and lung mapping center
KULMAP:人类肾脏、泌尿道和肺部绘图中心
- 批准号:
10237122 - 财政年份:2018
- 资助金额:
$ 2.3万 - 项目类别:
KULMAP: Human Kidney, urinary tract and lung mapping center
KULMAP:人类肾脏、泌尿道和肺部绘图中心
- 批准号:
9791201 - 财政年份:2018
- 资助金额:
$ 2.3万 - 项目类别:
Targeting the Apoptosis-Resistant Pulmonary Myofibroblast
靶向抗凋亡肺肌成纤维细胞
- 批准号:
8677065 - 财政年份:2012
- 资助金额:
$ 2.3万 - 项目类别:
Targeting the Apoptosis-Resistant Pulmonary Myofibroblast
靶向抗凋亡肺肌成纤维细胞
- 批准号:
8516090 - 财政年份:2012
- 资助金额:
$ 2.3万 - 项目类别:
Targeting the Apoptosis-Resistant Pulmonary Myofibroblast
靶向抗凋亡肺肌成纤维细胞
- 批准号:
8371194 - 财政年份:2012
- 资助金额:
$ 2.3万 - 项目类别:
Epigenetic Alterations in IPF Fibroblastic Foci
IPF 成纤维细胞灶的表观遗传改变
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7712750 - 财政年份:2009
- 资助金额:
$ 2.3万 - 项目类别:
Regulation of Fibroblast Phenotype in Lung Fibrosis
肺纤维化中成纤维细胞表型的调节
- 批准号:
7824718 - 财政年份:2009
- 资助金额:
$ 2.3万 - 项目类别:
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