ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPS

各族裔睡眠障碍与心血管健康的关联

基本信息

批准号：
8322017
负责人：
Susan S. Redline
金额：
$ 225.68万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-05 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8322017
关键词：
Accounting Address Affect African American Age Alcohol consumption Ancillary Study Ankle Apnea Arousal Asian Americans Atherosclerosis Autonomic nervous system Biochemical Breathing Calcium Candidate Disease Gene Cardiovascular Diseases Cardiovascular system Caucasians Caucasoid Race Chronic Circadian Rhythm Sleep Disorders Circadian Rhythms Clinical Collection Coronary artery Coronary heart disease Data Data Set Databases Diabetes Mellitus Disease Disease Outcome Dyslipidemias Employee Strikes Ethnic group Exposure to Future Gender Genetic Predisposition to Disease Genotype Health Heart failure High Prevalence Hispanics Home environment Hypertension Hypertrophy Hypoxemia Incidence Individual Inflammatory Intervention Intervention Studies Left Ventricular Dysfunction Left Ventricular Function Left Ventricular Hypertrophy Left Ventricular Mass Link Lipids Measurement Measures Medial Mental Depression Minority Minority Groups Modification Obesity Outcome Parents Participant Pathogenesis Pattern Phase Phenotype Physical activity Physiological Polysomnography Population Population Study Questionnaires Race Reading Records Research Resources Risk Risk Factors Role Sex Characteristics Sleep Sleep Apnea Syndromes Sleep Disorders Sleep Fragmentations Sleep Stages Sleep disturbances Slow-Wave Sleep Smoking Socioeconomic Status Stress Stroke Subgroup Testing Thick Time Variant Ventricular Function Woman Wrist actigraphy base cardiovascular disorder risk cohort design diabetes risk ethnic difference ethnic minority population fasting glucose genetic variant health disparity impaired glucose tolerance improved indexing men mortality neurophysiology nocturnal Hypoxemia novel racial and ethnic racial difference racial/ethnic difference sex shift work

项目摘要

DESCRIPTION (provided by applicant): Large differences in cardiovascular disease (CVD) outcomes have been observed across ethnic and gender groups which are not fully explained by consideration of traditional and novel CVD risk factors. For example, African Americans have a considerably higher prevalence of hypertension, left ventricular dysfunction, and heart failure than Caucasians despite lipid patterns and coronary artery calcium levels that generally show relatively favorable distributions. However, only limited research has addressed the role of sleep disorders in influencing CVD in ethnic minorities despite evidence that sleep disorders disproportionately affect minority populations and, through pro-inflammatory or autonomic nervous system dysregulation, operate as risk factors for hypertension and CVD. In this proposed ancillary study to the Multi-Ethnic Study of Atherosclerosis (MESA), we aim to perform standardized in-home polysomnography and 7-day wrist actigraphy in 2500 African American, Hispanic, Asian American and Caucasian individuals participating in MESA Exam 5 to derive indices of sleep apnea, quality, duration and timing. Newly collected sleep data will be rigorously standardized and comprehensively analyzed by a central Reading Center. By capitalizing on the rich clinical, physiological, anthropomorphic, and biochemical data collected longitudinally by MESA over 10 years, we will test the associations between indices of sleep apnea (apnea hypopnea index, nocturnal hypoxemia), sleep duration and quality, slow wave activity, and circadian placement with the indices of CVD risk, subclinical CVD and clinical CVD as outcomes. Finally, we will quantify the extent to which sleep disorders and patterns account for previously observed variations in CVD among ethnic and sex groups. By defining the role of sleep disorders in CVD in ethnic minorities, these activities may direct future interventions directed at reducing ethnic disparities in chronic health conditions.

描述（由申请人提供）：在种族和性别群体中已经观察到心血管疾病（CVD）结果的巨大差异，这些群体并未通过考虑传统和新型CVD风险因素的考虑来充分解释。例如，尽管脂质模式和冠状动脉钙水平通常显示出相对有利的分布，但非洲裔美国人的高血压，左心室功能障碍和心力衰竭的患病率要高得多。然而，尽管有证据表明睡眠障碍对少数群体的影响不成比例，并且通过促炎或自主神经神经系统失调，但仅有限的研究解决了睡眠障碍在影响CVD中的作用，尽管睡眠障碍会影响少数群体，但作为高血压和CVD的危险因素。在这项针对动脉粥样硬化多民族研究（MESA）的辅助研究中，我们旨在在2500名非裔美国人，西班牙裔美国人，亚裔美国人和高加索人进行MESA检查中进行标准化的室内多聚会学和7天的腕部表演，以获得睡眠Apnea，质量，质量，质量和时间。新收集的睡眠数据将经过严格的标准化，并通过中央阅读中心进行全面分析。 By capitalizing on the rich clinical, physiological, anthropomorphic, and biochemical data collected longitudinally by MESA over 10 years, we will test the associations between indices of sleep apnea (apnea hypopnea index, nocturnal hypoxemia), sleep duration and quality, slow wave activity, and circadian placement with the indices of CVD risk, subclinical CVD and clinical CVD作为结果。最后，我们将量化睡眠障碍和模式在多大程度上解释了种族和性别群体中CVD的差异。通过定义睡眠障碍在CVD中在少数民族中的作用，这些活动可能会指导未来的干预措施，该干预措施旨在减少慢性健康状况中的种族差异。