Phenotypic and Molecular Signatures for Sleep Apnea and Related Morbidities

睡眠呼吸暂停及相关疾病的表型和分子特征

• 批准号: 9244394
• 负责人: Susan S. Redline
• 金额: $ 105.75万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9244394
• 关键词: Address; Adult; Affect; African American; Age; Anatomy; Apnea; Asian Americans; Big Data; Biological; Candidate Disease Gene; Cardiovascular system; Child; Clinical Data; Clinical Trials; Cognitive; Cohort Studies; Collaborations; Continuous Positive Airway Pressure; Data; Development; Diabetes Mellitus; Disease; Disease Outcome; Disease susceptibility; Environment; Environmental Risk Factor; Ethnic Origin; Family; Functional disorder; Genetic; Genomics; Health; Healthcare; Heart failure; Heritability; Hypertension; Individual; Individual Differences; Intervention; Laboratories; Leadership; Link; Measures; Medicine; Metabolic; Modernization; Molecular; Molecular Profiling; Morbidity - disease rate; Multicenter Studies; Outcome; Pathway interactions; Patients; Pattern; Phenotype; Physiological; Play; Polysomnography; Problem behavior; Race; Research Personnel; Resources; Risk; Risk Factors; Role; Severities; Severity of illness; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Stages; Statistical Methods; Stents; Stream; Stroke; Subgroup; Technology; Translating; base; biobank; clinical care; disorder subtype; epidemiology study; experience; functional genomics; gene function; genetic association; genetic epidemiology; genetic variant; genome-wide; genomic data; improved; indexing; insight; multidisciplinary; novel; personalized medicine; precision medicine; prediction algorithm; programs; respiratory; sex; social; trait

I have over 25 years of experience in sleep medicine epidemiological research and have played a leading role in studies that address the contributions of genetic, social and environmental risk factors to sleep disorders, the influences of sleep on health outcomes in children and adults, and the role of sleep interventions in improving health outcomes. My collaborators, mentees and I have identified that sleep apnea (SA) is highly prevalent, disproportionately affects Asians and African American children, and is associated with significantly increased risks for developing hypertension, stroke, heart failure, diabetes, and behavioral problems. We also have identified variability in these outcomes by sex, race/ethnicity, age, and genetic background. We have characterized the patterns of heritability for several SDB traits and through use of family-based and cohort studies (>20,000 individuals) have identified genome-wide significant associations for genetic variants in biological candidate genes, and sex- and sleep stage-specific analyses have provided insight into mechanisms that may explain the known sex and REM/NREM differences in SA severity. Despite this progress, however, the underlying molecular and physiological mechanisms for SA are not well understood, limiting both our ability to predict which patients with SA are most vulnerable to adverse health outcomes and our ability to develop treatments that reflect individual differences in SDB pathophysiology. Our emerging data suggest that these gaps may be overcome through systematic analysis of larger sets of polysomnography data, deriving more precise SDB phenotypes that reflect specific sleep and respiratory patterns, and linking these phenotypes to genomic and clinical data. Through leadership in multiple national consortia and multi-center studies we are poised to make transformative advances in understanding the phenotypic variability and genetics of sleep apnea and related traits. We plan to harness a critical mass of data, including those in the National Sleep Research Resource and genetic, genomic and clinical data available through several consortia, including the Trans- Omics in Precision Medicine and Partners HealthCare Biobank. We will expand our genetics/epidemiology team with leaders in sophisticated respiratory phenotyping, developing a multi-disciplinary program that will systematically extract quantitative metrics of SA phenotypes and link these to genetics, genomics, specific treatment responsiveness, and cardiovascular, metabolic and cognitive outcomes. Through collaborations with functional genomics laboratories, we will help identify functional genetic variants and clarify the function of genes and pathways associated with SA. We will use sophisticated statistical methods to derive and validate personalized medicine prediction algorithms based on these data streams. This enhanced biological understanding of SA will be translated into improved clinical care through better-informed clinical trials. Finally, we will create an environment that nurtures the development of new investigators equipped to use modern technologies and “big data” to identify signatures of disease susceptibility and outcomes.

我有超过25年的睡眠医学流行病学研究经验，并发挥了主导作用