Increased Cardiovacular Risk and Early Natural Menopause in a Biracial Cohort

混血儿群体心血管风险增加和自然绝经提前

• 批准号: 8264560
• 负责人: Melissa Fair Wellons
• 金额: $ 2.02万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264560
• 关键词: African American; Age; Alabama; American; Atherosclerosis; Award; Blood Pressure; Blood Vessels; Body mass index; Cardiovascular Diseases; Clinic; Clinical Research; Commit; Communities; Development; Diastolic blood pressure; Disease Outcome; Doppler Ultrasound; Education; Environment; Epidemiologic Studies; Epidemiology; European; Evolution; Faculty; Funding; Glucose; Health; High Density Lipoprotein Cholesterol; Infertility; K-Series Research Career Programs; LDL Cholesterol Lipoproteins; Lead; Longitudinal Studies; Medial; Melissa; Menopause; Mentors; Mentorship; National Heart, Lung, and Blood Institute; Ovarian; Ovary; Overweight; Participant; Perfusion; Population; Premature Menopause; Premenopause; Prevention; Preventive; Preventive Medicine; Probability; Race; Recruitment Activity; Reproductive Endocrinology; Research; Research Personnel; Residencies; Resources; Risk; Risk Factors; Smoking; Techniques; Testing; Thick; Time; Training; Triglycerides; Universities; Woman; Women' s Health; Work; abstracting; age group; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular imaging; career; career development; cohort; experience; fasting glucose; follow-up; functional decline; interest; professor; programs; prospective; research and development; young adult

DESCRIPTION (provided by applicant): Melissa Wellons, MD, MHS is Assistant Professor in the Division of Preventive Medicine (DOPM) at the University of Alabama, Birmingham (DAB). During residency and chief residency, she developed a new research interest in women's health and cardiovascular disease (CVD) prevention. She is committed to an academic career in clinical research and has a proven track record of completing projects and working independently. A K-23 award will provide her with 1) further education in CVD epidemiology, 2) advanced training in biostatistical techniques, cardiovascular imaging, and reproductive endocrinology; 3) opportunity to test hypotheses regarding CVD risk in women, and 4) mentorship with outstanding investigators to become a highly productive researcher. Mentors: Cora E. Lewis, MD, MSPH, Professor, DOPM (Primary Mentor) brings expertise in CVD epidemiology and prevention in women. Dr. Nelda Wray, MD, MPH, Professor, DOPM (Co-Mentor) is an experienced CVD researcher and has mentored over 25 junior faculty. Environment: The DOPM at UAB offers a vibrant research environment and commits to protecting Dr. Wellons' time to develop her research career. Research: Dr. Wellons overarching hypothesis is that atherosclerosis of the ovarian vasculature during young adulthood may be a primary determinant of early menopause (natural menopause at an age # 46). Further stated, she posits that early menopause may be a manifestation of subclinical CVD. Her aims 1-2 include a bi-racial cohort of women from the NHLBI sponsored CARDIA study: a prospective, epidemiologic study of the determinants and evolution of CVD risk factors among young adults (ages 18-30) which completed its 20th year of follow-up in 2006. In this cohort, she will 1) investigate a marker of subclinical CVD (intimal-medial thickness) and its association with early menopause and 2) investigate the levels of and rate of change of CVD risk factors during women's young adulthood (the premenopausal time period) and their association with the likelihood of undergoing early menopause. For Aim 3, she will recruit women from the UAB Infertility Clinic and will assess the relationship between small ovarian volume (a marker of early menopause), ovarian perfusion, and CVD risk factors. Conclusion: The proposed career development and research plan will place Dr. Wellons on a 5-year trajectory to reach her target of becoming an independent investigator in CVD prevention in women. (End of Abstract)

简介（由申请人提供）：Melissa Wellons， MD， MHS是阿拉巴马大学伯明翰分校（DAB）预防医学部（DOPM）的助理教授。在住院医师和首席住院医师期间，她对女性健康和心血管疾病（CVD）预防产生了新的研究兴趣。她致力于临床研究的学术生涯，在完成项目和独立工作方面有着良好的记录。K-23奖将为她提供1)心血管疾病流行病学方面的进一步教育，2)生物统计技术、心血管成像和生殖内分泌学方面的高级培训；3)有机会检验关于女性心血管疾病风险的假设，4)与杰出的研究人员一起指导，成为一名高效的研究人员。导师：Cora E. Lewis，医学博士，MSPH，教授，DOPM（主要导师）带来了女性心血管疾病流行病学和预防方面的专业知识。Dr. Nelda Wray，医学博士，公共卫生硕士，教授，DOPM（联合导师）是一位经验丰富的心血管研究人员，指导了超过25名初级教师。环境：UAB的DOPM提供了一个充满活力的研究环境，并致力于保护Wellons博士的时间来发展她的研究事业。研究：Wellons博士的首要假设是，年轻时卵巢血管粥样硬化可能是早期绝经（46岁自然绝经）的主要决定因素。进一步指出，她认为早期绝经可能是亚临床心血管疾病的一种表现。她的目标1-2包括来自NHLBI赞助的CARDIA研究的双种族女性队列：一项关于年轻人（18-30岁）心血管疾病危险因素决定因素和演变的前瞻性流行病学研究，该研究于2006年完成了第20年的随访。在这个队列中，她将1)研究亚临床CVD的标志物（内膜-内侧厚度）及其与早期绝经的关系，2)研究女性成年早期（绝经前时期）CVD危险因素的水平和变异性，以及它们与早期绝经的可能性的关系。在Aim 3中，她将从UAB不孕不育诊所招募女性，并评估卵巢体积小（早期绝经的标志）、卵巢灌注和心血管疾病危险因素之间的关系。结论：提出的职业发展和研究计划将使Wellons博士走上5年的轨道，以实现她成为女性心血管疾病预防独立研究者的目标。（摘要结束）