CH/BIDMC/Harvard Medical School Neurology Resident Research Education Program

描述(由申请者提供)：该奖项的目的是为贝丝以色列女执事医疗中心(BIDMC)和波士顿儿童医院(CHB)神经学住院医师培训计划中的选定住院医师创造机会，在住院医师第三年和随后的奖学金年度参加为期9至24个月的强化、指导、研究教育经验。这项培训将为参与的住院医师为独立指导研究奖的成功竞争做好准备，并将促进从住院医师/研究员向临床医生-科学家的转变。每个参与者将与37名导师中的一人合作，这些导师来自CHB、BIDMC和哈佛医学院(HMS)的教职员工。所有这些人都有活跃的NIH资金和培训临床医生科学家的历史。拟议的导师涵盖临床和基础神经科学的所有主要领域，包括来自CHB的20名调查人员，来自BIDMC的16名调查人员，以及来自HMS的一名调查人员(前CHB神经生物学项目负责人、现任HMS神经生物学主席的Michael Greenberg博士)。其中17人从事临床/转化性神经科学研究，12人从事基础神经科学研究，8人同时参与基础和临床/转化性研究。导师不仅来自神经内科/神经生物学系，而且还来自CHB神经病理科、CHB神经放射科、CHB神经外科、BIDMC神经病理科和BIDMC麻醉科的疼痛研究计划。选定的驻地参与者将学习最先进的实验室技能，并将获得进行负责任的研究所需的关键专业知识。收集和分析的数据将为出版物和未来的NIH提案服务。该计划将由一个指导委员会管理，该委员会由PD/PI、部门主席和参与派驻计划的派驻主任组成。该委员会将共同努力，招募和挑选受训人员，监测他们的进展，并评估培训经验的有效性。 公共卫生相关性：影响神经系统的疾病仍然是医学研究的一个巨大挑战。发现这些疾病的病因，导致更早的诊断和更好的治疗，需要越来越依赖于概念复杂性和复杂方法的研究。目前的R25提案旨在培养能够将住院期间获得的临床专业知识与完善的、有重点的调查研究计划相结合的研究人员。神经科住院医生敏锐地意识到需要解决的问题，并特别有动力和精力来解决这些问题。CHB/BIDMC实习计划将成人神经学和儿童神经学结合在一个对基础和临床神经科学有很深了解的环境中。为R25选择的导师包括由NIH资助的领先的基础细胞和分子神经科学家，以及积极从事临床和基础神经科学并在培训内科科学家方面经验丰富并渴望培训的成功内科科学家。拟议计划的主要重点将是让医生为独立和竞争性研究做好准备。

DESCRIPTION (provided by applicant): The aim of this award is to create an opportunity for selected residents in the neurology residency training programs of the Beth Israel Deaconess Medical Center (BIDMC) and the Children's Hospital Boston (CHB) to participate for 9 to 24 months in an intensive, mentored, research educational experience during the third year of residency and subsequent fellowship years. This training will be designed to prepare participating residents for successful competition for independent mentored research awards, and will facilitate the transition from resident/fellow to clinician-scientist. Each participant will work with one of 37 mentors, who have been recruited from the faculties of CHB, BIDMC, and Harvard Medical School (HMS). All have active NIH funding and a history of training clinician-scientists. The proposed mentors cover all major areas of the clinical and basic neurosciences, and include 20 investigators from CHB, 16 investigators from BIDMC, and one investigator from HMS (Dr. Michael Greenberg, former leader of the Neurobiology Program at CHB, now Chair of Neurobiology at HMS). Seventeen of these investigators are engaged in clinical/translational neuroscience research, twelve conduct basic neuroscience research, and eight are involved in both basic and clinical/translational research. Mentors have been drawn not only from the Departments of Neurology/Neurobiology, but also from the CHB Division of Neuropathology, the CHB Division of Neuroradiology, the CHB Department of Neurosurgery, the BIDMC Division of Neuropathology, and the Pain Research Program of the BIDMC Department of Anesthesia. Selected resident participants will learn state-of- the-art laboratory skills and will acquire the critical expertise necessary for the conduct of responsible research. Data collected and analyzed will serve for publications as well as for future NIH proposals. The program will be governed by a Steering Committee consisting of the PD/PIs, the Department Chairs, and the Residency Directors of the participating residency programs. This Committee will work together to recruit and select trainees, to monitor their progress, and to evaluate the effectiveness of the training experience. PUBLIC HEALTH RELEVANCE: Illnesses affecting the nervous system remain a great challenge to medical research. The discovery of the causes of these illnesses, leading to earlier diagnosis and better treatments, requires research that relies increasingly on conceptual complexities and sophisticated methodologies. The present R25 proposal is aimed at developing researchers that can combine the clinical expertise obtained during residency with a well developed and focused investigative research program. Neurology residents are keenly aware of the problems that need to be solved and are especially motivated and energized to solve them. The CHB/BIDMC residency program combines both adult and child neurology within an environment that has great depth in basic and clinical neuroscience. Mentors chosen for the R25 include leading NIH funded basic cellular and molecular neuroscientists, as well as successful physician scientists actively engaged in clinical and basic neuroscience and experienced in, and eager to train physician scientists. The main focus of the proposed program will be to prepare physicians for independent and competitive research.