CORE A: ADMINISTRATIVE

核心 A：行政

• 批准号: 8914763
• 负责人: ALBERT Mark GALABURDA
• 金额: $ 2.96万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8914763
• 关键词: Animals; Brain; Collaborations; Connecticut; Databases; Dyslexia; Electroporation; Ethical Issues; Experimental Designs; Funding; Goals; Grant; Histologic; Housing; Institution; Israel; Laboratories; Life; Link; Medical center; Process; Protocols documentation; Publications; Rattus; Research; Research Project Grants; Resources; Susceptibility Gene; Universities; computerized data processing; data management; in utero; instrument; meetings; morphometry; neurobehavioral; programs

The Administrative and Research Core units will serve each of the Projects of the Program. In addition, these units will be a resource for grant supported research projects and protocols related to the overall goals of the participating laboratories. Dr. Galaburda, as Director of the Administrative Core (Core A), is the origin and clearing house of ideas that link the projects together, suggests coordinated changes, represents the Program to other institutions and programs, and motivates plans for future research and external collaborations. Dr. Galaburda will also review experimental design and data management, appropriate neurobehavioral instruments, ethical issues concerning animals, and budgetary effects on the Core units. The Executive Committee, which is composed of Drs. Galaburda, LoTurco, Fitch, and Rosen, will also review and advise on publications and meeting participation. The use of the Core budgetary resources will be at the discretion of the Core Director. Any redistribution of funds will require the approval of the Program Director. The use of the Cores is summarized in Table 1. The In Utero Electroporation Core (Core B) is located at the University of Connecticut and directed by Dr. Joseph J. LoTurco. This Core will be responsible for providing Research Projects with embryonicallytransfected live animals (Projects I and III) or perfused brains (Projects I and II). The Neurohistology, Morphometry, and Data Processing Core (Core C) is located at the applicant institution (Beth Israel Deaconess Medical Center) and is directed by Dr. Glenn D. Rosen. The Core will histologically process animals arising in the various research components, will morphometrically assess these brains, and will maintain a database of all animals being used in the Program Project.

行政和研究核心单位将为该方案的每个项目提供服务。此外, 这些单位将成为赠款支持的研究项目和与 参与实验室的总体目标。加拉布尔达博士担任行政核心主任 (核心A)，是将项目联系在一起的想法的起源和交流中心，建议协调 对其他机构和项目进行更改，代表项目，并激励未来研究计划 和外部合作。加拉布尔达博士还将审查实验设计和数据管理， 适当的神经行为工具，关于动物的伦理问题，以及预算 对核心单位的影响。 由Galaburda博士、LoTurco博士、Fitch博士和Rosen博士组成的执行委员会还将 对出版物和会议参与情况进行审查并提供建议。核心预算资源的使用 将由核心董事酌情决定。任何资金的重新分配都需要得到 项目总监。表1总结了内核的使用情况。 子宫内电穿孔核心(核心B)位于康涅狄格大学，由 约瑟夫·J·洛图科博士。该核心将负责为研究项目提供胚胎转基因 活体动物(项目I和项目III)或灌流大脑(项目I和项目II)。神经组织学， 形态测量和数据处理核心(核心C)位于申请机构(贝丝以色列女执事 医学中心)，由格伦·D·罗森博士执导。核心将在组织学上处理动物 在各种研究组成部分中产生的，将对这些大脑进行形态计量评估，并将 维护计划项目中使用的所有动物的数据库。