SWAN Repository III

描述(由申请人提供)：这项竞争性续展申请是为了继续维护和开展与SWAN储存库相关的活动，这些储存库是对来自5个民族的3302名妇女进行了为期10年的研究，在绝经过渡之前、期间和之后进行了每年的评估。这些资料库是全国妇女健康研究(SWAN)的一个分支，旨在支持、促进和扩展核心SWAN；此外，这些资料库还提供了一种机制，将SWAN的资源向更大的科学界开放。与这一竞争性更新的三个拟议具体目标有关的实施活动将：1)继续管理现有的170万份资料库标本，以及2009至2014年间因部署天鹅四号而增加的标本；2)扩大DNA资料库，这是被要求最多的标本类型，由于我们在细胞永生化方面的投资，它具有独特的可再生性；3)通过开发一个两级网络“数据仓库”，促进关于SWAN研究、其数据和资料库资源的有效信息交流；4)继续管理标本利用的申请审查程序和标本分配的行政管理，包括材料转让协议；5)采取策略促进标本的利用；以及6)扩大与天鹅研究及其资料库相关的遗传学研究的范围。

DESCRIPTION (provided by applicant): This competing renewal application is to provide for ontinued maintenance of and activities associated with the SWAN Repositories of serum, plasma, urine, DNA and transformed cells generated from a 10-year study of a population of 3302 women from 5 ethnic groups who have been evaluated annually prior to, during and following the menopausal transition. These Repositories, an arm of the Study of Women's Health Across the Nation (SWAN), are meant to support, facilitate and extend the Core SWAN; additionally, the Repositories provide a mechanism for opening the resources of SWAN to the greater scientific community. Implementing activities associated with three proposed specific aims of this competing renewal will 1) provide for the continued management of the current 1.7 million Repository specimens and the additional specimens that will accrue as a result of fielding SWAN IV in 2009 to 2014; 2) expand the DNA Repository, the most frequently requested specimen type that is uniquely renewable because of our investment in cell immortalization; 3) promote effective information interchange about the SWAN Study, its data and the Repository resources through development of a 2-level web-based "data warehouse"; 4) provide for continued administration of the application review process for specimen utilization and administrative management of specimen distribution including Material Transfer Agreements; 5) engage in strategies to promote utilization of specimens; and, 6) expand the scope of the genetics studies associated with the SWAN study and its Repository.