Study of Women's Health Across the Nation-Endocrine Lab

全国女性健康研究-内分泌实验室

• 批准号: 7071750
• 负责人: DANIEL S MCCONNELL
• 金额: $ 109.59万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7071750
• 关键词: Chinese American; Hispanic Americans; Japanese American; aging; androgens; biomarker; bone density; cardiovascular disorder risk; cooperative study; data collection; endocrinology; female; functional ability; hormone therapy; human middle age (35-64); human subject; longitudinal human study; menopause; menstrual cycle; morphometry; postmenopause; racial /ethnic difference; sample collection; sex hormones; women' s health

DESCRIPTION (provided by applicant): The Study of Women's Health Across the Nation (SWAN) is a multicenter, multiethnic, community based longitudinal study designed to characterize the biological, symptomatic and psychosocial changes that occur during the menopausal transition and the effects of these changes on women's health during and after the transition. Current and prior funding (SWAN I and II) has supported seven years of follow-up, at the end of which 60%of observable transitions to postmenopause will have occured. This competitve renewal application (SWAN III) requests funding to complete 10 cohort follow-up visits. This will allow us to capture 91% of observable transitions to postmenopause and obtain a more representative sample. The additional data will a focus on the late perimenopausal and early postmenopausal periods that have not been well studied. As women reach the end of early postmenopause (two years following the final menstrual period), we will shift from an annual to a bi-annual follow-up schedule with mail and telphone contact in the alternating years. This will set the stage for cost-effective and less intensive follow-up beyond SWAN III. We will continue our current observations and undertake new science in each of the four scientific project areas (ovarian aging; symptoms, risk factors, functioning and aging; cardiovascular risk factors; and determinants and outcomes of bone mass). New science includes measurement of vascular stiffness to assess early cardiovascular disease, vertebral morphometry using newly developed DEXA technology bone and body composition and circulating androgens as markers androgen biosynthesis. The latter will use an assay system developed by SWAN investigators. In addition, we will focus on linking the menopause and midlife experiences to age-related outcomes and chronic diseases, including physical and cognitive function. The additional follow-up will contribute to and expand the SWAN biological specimen repository (annual blood and urine samples as well as DNA and immortalized cells), a separately funded component that provides opportunities to address future hypotheses about health, disease, and aging. SWAN III will allow us to bring to fruition many of the original goals of SWAN. By building upon the rich foundation developed during SWAN I and II, and ultimately linking these data to age-related health outcomes, we will achieve unparalleled new insights into the role of the menopause on the health of American women.

描述(由申请人提供)：全国妇女健康研究(SWAN)是一项多中心、多种族、以社区为基础的纵向研究，旨在描述更年期过渡期间发生的生物学、症状和心理社会变化，以及这些变化对妇女健康在过渡期间和之后的影响。目前和以前的资金(SWAN I和SWAN II)支持了七年的后续行动，到七年结束时，60%的可观察到的绝经后过渡将发生。这份竞争对手续签申请(SWAN III)要求提供资金，以完成10个队列的后续访问。这将使我们能够捕捉到91%的可观察到的绝经后转变，并获得更具代表性的样本。额外的数据将集中在绝经后期、围绝经期和绝经早期，这些时期尚未得到很好的研究。随着女性绝经早期(最后一次月经后两年)的结束，我们将从每年一次的随访计划转变为每两年一次的随访计划，每隔几年通过邮件和电话联系。这将为在Swan III之后进行成本效益高、强度较小的后续研究奠定基础。我们将继续目前的观察，并在四个科学项目领域(卵巢老化；症状、风险因素、功能和衰老；心血管风险因素；骨量的决定因素和结果)的每一个领域开展新的科学研究。新的科学包括测量血管硬度以评估早期心血管疾病，使用新开发的DEXA技术进行椎体形态测量，骨和身体成分以及循环雄激素作为雄激素生物合成的标志。后者将使用由Swan调查人员开发的检测系统。此外，我们将专注于将更年期和中年经历与年龄相关的结果和慢性病联系起来，包括身体和认知功能。额外的后续行动将有助于并扩大天鹅生物标本库(每年的血液和尿液样本以及DNA和永生化细胞)，这是一个单独资助的组成部分，为解决未来关于健康、疾病和衰老的假设提供了机会。《天鹅三号》将让我们实现《天鹅三号》最初的许多目标。通过建立在第一次和第二次天鹅行动期间开发的丰富基础上，并最终将这些数据与年龄相关的健康结果联系起来，我们将对更年期对美国女性健康的作用获得无与伦比的新见解。