SWAN Repository III

SWAN 存储库 III

• 批准号: 8285420
• 负责人: DANIEL S MCCONNELL
• 金额: $ 51.7万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8285420
• 关键词: Aging; Automobile Driving; Award; Awareness; Biological Assay; Calibration; Cell Extracts; Cell Line; Collaborations; Collection; Communities; DNA; Data; Data Collection; Data Set; Databases; Development; Electronics; Environmental Exposure; Equipment and supply inventories; Ethnic group; Financial Support; Genetic; Genetic Databases; Genetic Materials; Genotype; Internet; Investments; Laboratories; Left; Link; Maintenance; MeSH Thesaurus; Menopause; Menstrual cycle; Meta-Analysis; Methodology; Nature; Neurotransmitters; Office of Administrative Management; Online Systems; Plasma; Population; Productivity; Publications; Quality Control; Recording of previous events; Recovery; Reporting; Research; Research Design; Resources; Sampling; Science; Shipping; Ships; Specimen; Specimen Handling; Urine; Whole Blood; Woman; Women' s Health; arm; cell immortalization; cell transformation; cohort; cost; diaries; field study; genetic resource; genome wide association study; immortalized cell; material transfer agreement; middle age; programs; repository; sample collection; social; time use; urinary

DESCRIPTION (provided by applicant): This competing renewal application is to provide for ontinued maintenance of and activities associated with the SWAN Repositories of serum, plasma, urine, DNA and transformed cells generated from a 10-year study of a population of 3302 women from 5 ethnic groups who have been evaluated annually prior to, during and following the menopausal transition. These Repositories, an arm of the Study of Women's Health Across the Nation (SWAN), are meant to support, facilitate and extend the Core SWAN; additionally, the Repositories provide a mechanism for opening the resources of SWAN to the greater scientific community. Implementing activities associated with three proposed specific aims of this competing renewal will 1) provide for the continued management of the current 1.7 million Repository specimens and the additional specimens that will accrue as a result of fielding SWAN IV in 2009 to 2014; 2) expand the DNA Repository, the most frequently requested specimen type that is uniquely renewable because of our investment in cell immortalization; 3) promote effective information interchange about the SWAN Study, its data and the Repository resources through development of a 2-level web-based "data warehouse"; 4) provide for continued administration of the application review process for specimen utilization and administrative management of specimen distribution including Material Transfer Agreements; 5) engage in strategies to promote utilization of specimens; and, 6) expand the scope of the genetics studies associated with the SWAN study and its Repository.

描述（由申请人提供）：本次竞争更新申请旨在持续维护 SWAN 存储库并提供与血清、血浆、尿液、DNA 和转化细胞相关的活动，这些存储库是对来自 5 个种族的 3302 名女性进行了为期 10 年的研究，每年在绝经过渡之前、期间和之后进行评估。这些存储库是全国妇女健康研究 (SWAN) 的一个分支，旨在支持、促进和扩展核心 SWAN；此外，存储库还提供了一种向更大的科学界开放 SWAN 资源的机制。实施与本次竞争性更新的三个拟议具体目标相关的活动将： 1) 继续管理当前 170 万个储存库样本以及因 2009 年至 2014 年部署 SWAN IV 而产生的额外样本； 2) 扩展 DNA 存储库，这是最常需要的样本类型，由于我们在细胞永生化方面的投资，该样本类型具有独特的可更新性； 3) 通过开发基于网络的二级“数据仓库”，促进有关 SWAN 研究、其数据和存储库资源的有效信息交换； 4) 规定标本使用申请审查流程的持续管理和标本分发的行政管理，包括材料转让协议； 5）制定促进标本利用的策略； 6) 扩大与 SWAN 研究及其存储库相关的遗传学研究范围。