CENTRALIZED RESEARCH INSTRUMENTATION CORE

集中研究仪器核心

• 批准号: 8360146
• 负责人: SANDRA PENA DE ORTIZ
• 金额: $ 14.17万
• 依托单位: UNIVERSITY OF PUERTO RICO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360146
• 关键词: Academia; Area; Biomedical Research; Clinical; Collaborations; Competence; Consult; Core Facility; Development; Educational workshop; Environment; Fostering; Funding; Genetic; Genomics; Genotype; Goals; Grant; Human; Industry; Institution; Island; Manuscripts; Medical; Mentors; Mentorship; National Center for Research Resources; Piedra; Preparation; Principal Investigator; Productivity; Proteins; Proteomics; Puerto Rico; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Running; Science; Scientist; Services; Source; Students; Technology; Time; Training; United States National Institutes of Health; Universities; Validation; Work; X-Ray Crystallography; career; career development; cost; empowered; experience; functional genomics; instrument; instrumentation; investigator training; meetings; member; new technology; programs; research and development; research study; technology development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Centralized Research and Instrumentation Core: The BioMolecular Sciences Network (BMSN). The BMSN embodies the integration of the principal BioMolecular Sciences Resources (BMSRs) in Puerto Rico as part of the research and career development objectives of the Puerto Rico Alliance for the Advancement of Biomedical Research Excellence (PRAABRE). Our overall goal in the BMSN is to work in a concerted fashion, by providing mentorship and scientific support, leading to the empowering of PRAABRE-supported investigators and students from primarily undergraduate institutions (PUIs) in the Island. We envision that fostering a concerted, integrated, and collaborative environment in Puerto Rico catalyzed by the BMSN will i) contribute to the expansion of scientific competence among researchers and students at PUIs and ii) help create productive partnerships between these investigators (including their mentors and collaborators) and those directing active research endeavors and instrumentation facilities (the Core Facility Coordinators) within the two main PRAABRE mentoring institutions in the Island: the Rio Piedras and Medical Sciences Campuses of the University of Puerto Rico (UPR-RP and UPR-MSC), respectively. These goals will be achieved by the integration of researchers in the two major areas of the BMSN: genomics and proteomics. The integration of resources and scientific expertise available at the BMSN will empower researchers and augment their scientific competence, resulting in a better use of BMSRs and enhanced competitiveness. In addition, the proposed activities will result in more active networking among existing instrumentation facilities and BMSN scientists, thus impacting the collaborative, consulting, training, and service capabilities for all members of PRAABRE. Specific Aim 1: Integration of existing Instrumentation Facilities. Six facilities dedicated to genomics and proteomics research, including new technology development constitute the BMSN. The specialized areas represented by the BMSN are Functional Genomics, Genomics and Genotyping, Human and Clinical Genetics, Proteomics, and Protein X-Ray Crystallography. The BMSN Director, Dr. Sandra Pena de Ortiz, together with the Genomics and Proteomics Area Leaders (Drs. Tomas Hrbek and Irving Vega, respectively), will oversee the integration and collaboration activities proposed to provide scientific exchange and expertise among Core Facility Coordinators and PRAABRE-supported investigators, at the same time maximizing the use and development of BMSRs in Puerto Rico. Specific Aim 2: Competence Enhancement: Empowering PUI's investigators, students and research staff in the fields represented and developed at the BMSN. The utilization of the technology available will be maximized when researchers are capacitated to understand how these instruments and technologies may impact their research. The Core Facility Coordinators will continue to develop productive collaborations between the academia and industry by offering and developing new Thematic Workshops to train investigators, students and research staff at PUI's and industry in Puerto Rico. The workshops will consist of theoretical and hands-on experiences. The development and execution of this specific aim will not only contribute to the increased usage of instrumentation facilities within the BMSN, but more importantly, empower researchers in Puerto Rico, especially those at PUIs to implement new biomolecular approaches and resources to their research projects with the goal of enhancing competitiveness, productivity, and scientific impact. Specific Aim 3: Provide scientific support to the PRAABRE supported investigators at PUIs and to the overall scientific network in the Island. The development of new investigators mainly at PUIs is one of the objectives of the PRAABRE program. The BMSN will foster the scientific development of investigators funded through this program by providing mentorship, guidance and scientific support. The projects that are part of the PRAABRE Research Core will benefit from the technology and expertise available at the BMSN. The Core Facility Coordinators will encourage one-on-one meetings for experiment planning, validation strategies and manuscript preparation. This support will enhance the productivity and, consequently, competitiveness of PUIs investigators. This aim will run concurrently with the above mentioned Competence Enhancement component. In general, the BMSN will foster the development of research projects and directly impact the research careers of investigator at PUIs and other academic institutions in Puerto Rico.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 集中研究和仪器核心：生物分子科学网络（BMSN）。BMSN体现了波多黎各主要生物分子科学资源（BMSRs）的整合，作为波多黎各生物医学研究卓越促进联盟（PRAABRE）的研究和职业发展目标的一部分。我们在BMSN的总体目标是以协调一致的方式工作，通过提供指导和科学支持，导致PRAABRE支持的调查人员和来自岛上主要本科院校（PUI）的学生赋权。我们设想 促进建立一个协调一致的、综合的、由BMSN推动的波多黎各的科学和合作环境将i）有助于扩大PUI研究人员和学生的科学能力，ii）有助于在这些研究人员之间建立富有成效的伙伴关系（包括他们的导师和合作者）和那些指导积极的研究工作和仪器设备在岛上两个主要的PRAABRE指导机构（Rio Piedras和医学科学校区）内， 分别为波多黎各大学（UPR-RP和UPR-MSC）。这些目标将通过整合BMSN两个主要领域的研究人员来实现：基因组学和蛋白质组学。BMSN现有资源和科学专门知识的整合将增强研究人员的能力，提高他们的科学能力，从而更好地利用BMSRs并提高竞争力。此外，拟议的活动还将使现有的仪器设施和生物医学科学网科学家之间建立更积极的网络联系， 从而影响PRAABRE所有成员的协作、咨询、培训和服务能力。 具体目标1：整合现有仪器设备。六个致力于基因组学和蛋白质组学研究，包括新技术开发的设施构成了BMSN。BMSN所代表的专业领域是功能基因组学、基因组学和基因分型、人类和临床 遗传学、蛋白质组学和蛋白质X射线晶体学。BMSN主任Sandra佩纳德奥尔蒂斯博士将与基因组学和蛋白质组学领域负责人（分别为Tomas Hrbek博士和欧文维加博士）一起监督拟议的整合和合作活动，以在核心设施协调员和PRAABRE支持的研究者之间提供科学交流和专业知识，同时最大限度地利用和开发波多黎各的BMSRs。 具体目标二：能力提升：赋予PUI的调查人员，学生和研究人员在BMSN代表和发展的领域。当研究人员有能力了解这些工具和技术如何影响他们的研究时，将最大限度地利用现有技术。核心基金协调员将继续制定富有成效的 通过提供和开发新的专题研讨会，以培训PUI和波多黎各工业界的调查人员，学生和研究人员，促进学术界和工业界之间的合作。讲习班将包括理论和实践经验。这一具体目标的制定和执行不会 这不仅有助于增加BMSN内仪器设施的使用，更重要的是，使波多黎各的研究人员，特别是那些在PUI的研究人员能够在他们的研究项目中实施新的生物分子方法和资源，以提高竞争力，生产力和科学性。 冲击 具体目标3：为PRAABRE支持的PUI调查人员和岛上的整个科学网络提供科学支持。PRAABRE方案的目标之一是主要在PUI培养新的调查员。BMSN将通过提供指导，指导和科学支持，促进通过该计划资助的研究人员的科学发展。作为PRAABRE研究核心的一部分的项目将受益于BMSN提供的技术和专业知识。核心设施协调员将鼓励就实验规划、验证策略和手稿准备举行一对一会议。这种支持将提高生产力，因此， 研究人员的竞争力。这一目标将与上述能力提高部分同时实施。总的来说，BMSN将促进研究项目的发展，并直接影响波多黎各的PUI和其他学术机构的研究人员的研究生涯。