LBRN: ADMINISTRATIVE CORE

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这种竞争性延续INBRE应用的总体目标是促进整个路易斯安那州生物医学研究活动的增长。以前的资金使路易斯安那州生物医学研究网络（LBRN），为跨学科和机构间的研究，教育，培训和指导计划奠定了坚实的基础。在目前的申请中，越来越多的重点放在发展生物医学研究主要是本科院校（PUI）。LBRN计划准备增加该州的生物医学劳动力，并创建一个由未来所需的研究科学家组成的管道。在这方面，LBRN计划显然符合新的资助机会公告中指出的四个目标，并将：1。继续建设生物医学研究能力; 2.建立研究基地; 3.为广泛的本科生提供研究机会，以及4.加强国家劳动力的科学技术知识基础。 为改进整个LBRN计划，进行了重大修改。简要地说，这些措施包括：形成更具体的主题领域，澄清核心功能和结构，包括现有的COBREs，扩大PUI网络，包括路易斯安那州的泽维尔大学，扩大生物医学研究密集型机构的参与，包括杜兰国家灵长类动物研究中心（TNPRC），彭宁顿生物医学研究中心（PBRC）和位于什里夫波特的路易斯安那州立大学健康科学中心（LSUHSC-S）。此外，路易斯安那州董事会（La BoR）已同意为支持本科生生物医学研究的新申请提供超过100万美元的资金。本次更新INBRE应用的主要目标，以提高生物医学研究在路易斯安那州的竞争力，将通过以下具体目标来实现。 具体目标一：维护和扩大以前建立的全州基础设施和智力研究网络，支持跨学科的生物医学研究。这一目标将通过继续支持南方大学、巴吞鲁日（SU）、路易斯安那大学门罗分校（乌尔姆）、路易斯安那理工大学（LA Tech）、路易斯安那州立大学什里夫波特（LSU-S）（什里夫波特）、路易斯安那州泽维尔大学（Xavier）的主要LBRN PUI网络的物理网络基础设施组件以及路易斯安那州内数量不断增加的主要生物医学研究中心和COBREs来实现。这些机构和PUI将通过LBRN和其他主要生物医学研究中心和COBREs直接组织的研讨会，正在进行的工作，主题讨论小组和研讨会进行智力联系 具体目标二：通过指导研究的支持和加强沟通，扩大和提高PUI主要校区生物医学研究人员的临界质量。具体的研究项目和较小的试点项目已被选定的基础上的科学价值和他们的使命，目标和计划的参与PUI的强烈配合。这些项目将围绕三个专题领域进行安排。这些是1.计算和结构生物学（CSB），2。疾病的分子机制（MMD）和3.治疗和预防医学（TPM）。 具体目标三：通过为该州所有机构提供夏季研究机会，提高学生对整个路易斯安那州生物医学研究职业的兴趣。将通过合作推广活动支持研究生和本科生以及教职员工日益多样化的研究机会 具体目标四：通过详细跟踪研究成果，人力资源开发和参与机构之间的富有成效的合作，评估，评估和持续监测LBRN的进展。所有的个人研究项目将评估他们对出版物，演示文稿和竞争性资助的建议，每年两次的进展。此外，PUI校园的调查人员，初级科学家和项目的临界质量，多样性和专业知识的可测量，定量增长，以及生物信息学网络在支持全州教育和研究方面的增长和有效性将受到密切监测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of this competitive continuation INBRE application is to facilitate the growth of biomedical research activities throughout the State of Louisiana. Previous funding enabled the Louisiana Biomedical Research Network (LBRN), to establish a strong foundation for interdisciplinary and interinstitutional research, education, training and mentoring programs. In the current application, increased emphasis has been placed on developing biomedical research within predominantly undergraduate institutions (PUI). The LBRN programs are poised to increase the biomedical workforce within the state and create a pipeline of needed future research scientists. In this regard, the LBRN program clearly meets the four objectives noted in the new Funding Opportunity Announcement and will: 1. continue to build biomedical research capacity; 2. build a research base; 3. provide research opportunities for a wide range of undergraduate students, and 4. enhance the science and technology knowledge base of the State's workforce. Significant changes have been made to improve the overall LBRN program. Briefly these include; the formation of more specific thematic areas, the clarification of CORE functions and structure to include existing COBREs, the expansion of the network of PUIs to include Xavier University of Louisiana, the expansion of participation by biomedical-research intensive institutions to include the Tulane National Primate Research Center (TNPRC), the Pennington Biomedical Research Center (PBRC) and the Louisiana State University Health Science Center at Shreveport (LSUHSC-S). Moreover, the Louisiana Board of Regents (La BoR) has agreed to provide a match of over $1million to the new application for support of undergraduate biomedical research. The major objective of this renewal INBRE application, to improve the competitiveness of biomedical research in Louisiana, will be accomplished through the following specific aims. Specific Aim I: Maintain and expand the previously established state-wide infrastructure and intellectual research network supporting interdisciplinary biomedical research. This aim will be accomplished by continuing to support the physical cyber infrastructural components of the primary LBRN PUI network of Southern University, Baton Rouge (SU), University of Louisiana at Monroe (ULM), Louisiana Tech University (LA Tech) in Ruston and LSU Shreveport (LSU-S) in Shreveport, Xavier University of Louisiana (XULA) and the expanded number of major biomedical research centers and COBREs within Louisiana. These institutions and the PUIs will be intellectually linked by workshops, works in progress, thematic discussion groups and seminars organized directly by LBRN and other major biomedical research centers and COBREs Specific Aim II: Expand and improve the critical mass of biomedical investigators at primary PUI campuses through the support of mentored research, and enhanced communication. Specific research projects and smaller pilot projects have been selected on the basis of scientific merit and their strong fit with the mission, goals, and plans of the participating PUIs. The projects will be organized around three thematic areas. These are 1. Computational and Structural Biology (CSB), 2. Molecular Mechanisms of Disease (MMD), and 3.Therapeutics and Preventive Medicine (TPM). Specific Aim III: Increase student interest in biomedical research careers throughout Louisiana by providing summer research opportunities to all institutions within the State. Research opportunities for an increasingly diverse pool of both graduate and undergraduate students and faculty will be supported through collaborative outreach activities Specific Aim IV: Evaluate, assess and continuously monitor the progress within LBRN through detailed tracking of research accomplishments, the development of human resources, and productive collaborations among participating institutions. All individual research projects will be evaluated for their progress toward publications, presentations, and competitively-funded proposals twice per year. In addition, the measurable, quantitative increases in the critical mass, diversity, and expertise of investigators, junior scientists and programs at PUI campuses, and the growth and effectiveness of the bioinformatics network in supporting education and research across the State will be closely monitored.