LBRN: ADMINISTRATIVE CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这一竞争延续INBRE申请的总体目标是促进整个路易斯安那州生物医学研究活动的增长。之前的资助使路易斯安那州生物医学研究网络(LBRN)为跨学科和跨机构的研究、教育、培训和指导计划奠定了坚实的基础。在目前的应用中，越来越重视在以本科生为主的机构(PUI)内开展生物医学研究。LBRN计划准备增加该州的生物医学劳动力，并创造出一条未来需要的研究科学家的管道。在这方面，LBRN计划明确符合新的资助机会公告中提到的四个目标，并将：1.继续建设生物医学研究能力；2.建设研究基地；3.为广泛的本科生提供研究机会；4.增强国家劳动力的科技知识基础。 在改善整体LBRN计划方面做出了重大变化。简而言之，这些活动包括：形成更具体的专题领域，澄清核心职能和结构，将现有的眼镜蛇纳入其中，扩大PUI网络，将路易斯安那的泽维尔大学包括在内，扩大生物医学研究密集型机构的参与范围，将杜兰国家灵长类动物研究中心、彭宁顿生物医学研究中心和位于什里夫波特的路易斯安那州立大学健康科学中心纳入其中。此外，路易斯安那州董事会(La Bor)已同意为新的本科生物医学研究支持申请提供100多万美元的匹配。更新INBRE申请的主要目标是提高路易斯安那州生物医学研究的竞争力，将通过以下具体目标实现。 具体目标一：维护和扩大以前建立的支持跨学科生物医学研究的全州基础设施和智力研究网络。这一目标将通过继续支持南方大学、巴吞鲁日大学(SU)、路易斯安那大学门罗分校(ULM)、鲁斯顿的路易斯安那理工大学(LA Tech)和什里夫波特的路易斯安那州立大学什里夫波特分校(LSU-S)的主要网络基础设施组件以及路易斯安那州的主要生物医学研究中心和科布雷的扩大数量来实现。这些机构和PUI将通过由LBRN和其他主要生物医学研究中心和科布雷直接组织的研讨会、正在进行的工作、专题讨论小组和研讨会在智力上联系在一起 具体目标二：通过辅导性研究的支持和加强沟通，扩大和改善初级PUI校区的生物医学研究人员的临界数量。具体的研究项目和较小的试点项目是根据科学价值以及它们与参与的PUI的使命、目标和计划的高度契合而选择的。这些项目将围绕三个主题领域组织。它们是：1.计算和结构生物学(CSB)；2.疾病分子机制(MMD)；3.治疗和预防医学(TPM)。 具体目标三：通过向路易斯安那州内所有机构提供暑期研究机会，提高学生对整个路易斯安那州生物医学研究职业的兴趣。将通过协作性外展活动，为日益多样化的研究生和本科生和教职员工提供研究机会 具体目标四：通过详细跟踪研究成果、人力资源开发和参与机构之间富有成效的合作，评价、评估和持续监测LBRN内的进展情况。所有单独的研究项目每年将接受两次评估，以确定其在发表、演示和竞争资助的提案方面的进展情况。此外，将密切监测研究人员、初级科学家和PUI校园项目的临界质量、多样性和专业知识的可测量的、定量的增长，以及生物信息学网络在支持全州教育和研究方面的增长和有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of this competitive continuation INBRE application is to facilitate the growth of biomedical research activities throughout the State of Louisiana. Previous funding enabled the Louisiana Biomedical Research Network (LBRN), to establish a strong foundation for interdisciplinary and interinstitutional research, education, training and mentoring programs. In the current application, increased emphasis has been placed on developing biomedical research within predominantly undergraduate institutions (PUI). The LBRN programs are poised to increase the biomedical workforce within the state and create a pipeline of needed future research scientists. In this regard, the LBRN program clearly meets the four objectives noted in the new Funding Opportunity Announcement and will: 1. continue to build biomedical research capacity; 2. build a research base; 3. provide research opportunities for a wide range of undergraduate students, and 4. enhance the science and technology knowledge base of the State's workforce. Significant changes have been made to improve the overall LBRN program. Briefly these include; the formation of more specific thematic areas, the clarification of CORE functions and structure to include existing COBREs, the expansion of the network of PUIs to include Xavier University of Louisiana, the expansion of participation by biomedical-research intensive institutions to include the Tulane National Primate Research Center (TNPRC), the Pennington Biomedical Research Center (PBRC) and the Louisiana State University Health Science Center at Shreveport (LSUHSC-S). Moreover, the Louisiana Board of Regents (La BoR) has agreed to provide a match of over $1million to the new application for support of undergraduate biomedical research. The major objective of this renewal INBRE application, to improve the competitiveness of biomedical research in Louisiana, will be accomplished through the following specific aims. Specific Aim I: Maintain and expand the previously established state-wide infrastructure and intellectual research network supporting interdisciplinary biomedical research. This aim will be accomplished by continuing to support the physical cyber infrastructural components of the primary LBRN PUI network of Southern University, Baton Rouge (SU), University of Louisiana at Monroe (ULM), Louisiana Tech University (LA Tech) in Ruston and LSU Shreveport (LSU-S) in Shreveport, Xavier University of Louisiana (XULA) and the expanded number of major biomedical research centers and COBREs within Louisiana. These institutions and the PUIs will be intellectually linked by workshops, works in progress, thematic discussion groups and seminars organized directly by LBRN and other major biomedical research centers and COBREs Specific Aim II: Expand and improve the critical mass of biomedical investigators at primary PUI campuses through the support of mentored research, and enhanced communication. Specific research projects and smaller pilot projects have been selected on the basis of scientific merit and their strong fit with the mission, goals, and plans of the participating PUIs. The projects will be organized around three thematic areas. These are 1. Computational and Structural Biology (CSB), 2. Molecular Mechanisms of Disease (MMD), and 3.Therapeutics and Preventive Medicine (TPM). Specific Aim III: Increase student interest in biomedical research careers throughout Louisiana by providing summer research opportunities to all institutions within the State. Research opportunities for an increasingly diverse pool of both graduate and undergraduate students and faculty will be supported through collaborative outreach activities Specific Aim IV: Evaluate, assess and continuously monitor the progress within LBRN through detailed tracking of research accomplishments, the development of human resources, and productive collaborations among participating institutions. All individual research projects will be evaluated for their progress toward publications, presentations, and competitively-funded proposals twice per year. In addition, the measurable, quantitative increases in the critical mass, diversity, and expertise of investigators, junior scientists and programs at PUI campuses, and the growth and effectiveness of the bioinformatics network in supporting education and research across the State will be closely monitored.