Research Infrastructure in Minority Institutions (RIMI) at Tougaloo College

描述（由申请人提供）：本拟议计划的总体目标是：1。提高Tougaloo学院RIMI教师的科学生产力和研究竞争力。2.翻新物理空间，为学生提供更有利的研究/学习环境。3.为RIMI CORE的教师和学生提供提案开发和赠款管理培训。4.在研究领域培训学生，并提供指导，以确保个人研究项目的成功。5.提高生物医学研究能力和生产力，这将允许Tougaloo学院建立一个生物医学设施。6.为了加强教师的研究工作，促进和扩大Tougaloo学院教师与主要研究密集型大学研究教师的生物医学合作，三个Tougaloo学院教师将与合作机构的教师合作。Bettye Sue Hennington博士将与大学医学中心的教师合作开展她的子项目，题为“使用质谱法表征转录蛋白质和F2-异前列烷”。“UMC在理解低出生体重个体晚年疾病发展风险增加的机制方面有经验。其目前的研究致力于氧化应激在低出生体重高血压中的作用。 活性氧增加导致氧化应激与人类心血管疾病和高血压的发病机制有关。证明氧化应激和疾病之间的直接联系是困难的，部分原因是该领域使用的分析方法的多样性。博士RajenvanRajnarayanan将与杰克逊州立大学合作，他的子项目#题为“雌激素受体钙结合蛋白界面作为目标的新疗法的发现抗雌激素耐药乳腺癌。“这些研究具有实质性的潜在益处，特别重要，因为他莫昔芬耐药乳腺癌构成重大风险。Jinghe Mao博士将与南密西西比大学合作开展题为“非裔美国成人II型糖尿病患者外周血脂质组学和DMA微阵列分析”的主题研究。“USM的工作人员专门从事微阵列和代谢组学数据分析技术。他们使用广泛的工业和研究标准软件来分析基因表达和代谢组学数据。

DESCRIPTION (provided by applicant): The overall objectives of this proposed program are to: 1. to enhance the scientific productivity and research competitiveness of RIMI faculty at Tougaloo College. 2. To renovate physical space to provide a more conducive research/learning environment for students. 3. To provide proposal development and grant management training to RIMI CORE faculty and students. 4. To train students in the field of research and provide mentoring to ensure success on individual research projects. 5. Improve biomedical research capacity and productivity, which will permit Tougaloo College to establish a Biomedical Facility. 6. To strengthen faculty research endeavors by promoting and expanding biomedical collaborations of Tougaloo College faculty with research faculty at major research intensive universities Three Tougaloo College faculty will collaborate with faculty from the collaborating institutions. Dr. Bettye Sue Hennington will collaborate with faculty from the University Medical Center on her subproject entitled, "Using Mass Spectroscopy to Characterize Transcription Proteins and F2-isoprostanes." UMC has experience in understanding the mechanisms linking increased risk for development of disease in later life in individuals born with low birth weight. Its current research addresses the role of oxidative stress in low birth weight hypertension. Increased reactive oxygen species leading to oxidative stress is related to the pathogenesis of human cardiovascular disease and hypertension. Demonstrating a direct link between oxidative stress and disease is difficult, partly due to the diversity of analytical procedures used in the field. Dr. Dr. Rajendram Rajnarayanan will collaborate with Jackson State University on his SUBPROJECT #entitled "Estrogen Receptor-Calcium Binding Protein Interfaces as Targets for the Discovery of Novel Therapeutics against Antiestrogen Resistant Breast Cancers." These studies have substantial potential benefits and are particularly important since tamoxifen-resistant breast cancers pose a significant risk. Dr. Jinghe Mao will collaborate with the University of Southern Mississippi on her SUBJECT entitled, "Lipidomic and DMA Microarray Analyses of Peripheral Blood in African-American Adults with Type II Diabetes." The USM staff specializes in microarray and metabolomics data analysis techniques. They use a wide range of industry and research standard software to analyze gene expression and metabolomics data.