Research Infrastructure in Minority Institutions (RIMI) at Tougaloo College

描述(由申请者提供)：该计划的总体目标是：1。提高图伽鲁学院RIMI教员的科学生产力和研究竞争力。2.翻新物理空间，为学生提供更有利的研究/学习环境。3.为RIMI的核心教职员工和学生提供提案开发和授权管理培训。4.培训学生在研究领域，并提供指导，以确保个人研究项目的成功。5.提高生物医学研究能力和生产率，这将使Tougaloo学院能够建立生物医学设施。6.为了通过促进和扩大Tougaloo学院教职员工与主要研究密集型大学的研究人员的生物医学合作，加强教员的研究工作，三名Tougaloo学院教职员工将与合作机构的教职员工合作。Bettye Sue Hennington博士将与大学医学中心的教职员工合作开展她的子项目，题为“使用质谱学来表征转录蛋白和F2-异前列腺素。”UMC在了解出生体重低的人在晚年罹患疾病风险增加的机制方面有经验。它目前的研究解决了氧化应激在低出生体重高血压中的作用。导致氧化应激的活性氧物种增加与人类心血管疾病和高血压的发病机制有关。证明氧化应激和疾病之间的直接联系是困难的，部分原因是该领域使用的分析方法的多样性。Rajendram Rajnarayanan博士将与杰克逊州立大学合作开展他的子项目#，题为“雌激素受体-钙结合蛋白接口作为发现抗雌激素抵抗型乳腺癌新疗法的目标”。这些研究有很大的潜在好处，尤其重要，因为对他莫昔芬耐药的乳腺癌构成了巨大的风险。毛静和博士将与南密西西比大学合作，研究题为“非裔美国成人II型糖尿病患者外周血的脂质组学和DNA微阵列分析”。USM的工作人员专门从事微阵列和代谢组学数据分析技术。他们使用广泛的工业和研究标准软件来分析基因表达和代谢组学数据。

DESCRIPTION (provided by applicant): The overall objectives of this proposed program are to: 1. to enhance the scientific productivity and research competitiveness of RIMI faculty at Tougaloo College. 2. To renovate physical space to provide a more conducive research/learning environment for students. 3. To provide proposal development and grant management training to RIMI CORE faculty and students. 4. To train students in the field of research and provide mentoring to ensure success on individual research projects. 5. Improve biomedical research capacity and productivity, which will permit Tougaloo College to establish a Biomedical Facility. 6. To strengthen faculty research endeavors by promoting and expanding biomedical collaborations of Tougaloo College faculty with research faculty at major research intensive universities Three Tougaloo College faculty will collaborate with faculty from the collaborating institutions. Dr. Bettye Sue Hennington will collaborate with faculty from the University Medical Center on her subproject entitled, "Using Mass Spectroscopy to Characterize Transcription Proteins and F2-isoprostanes." UMC has experience in understanding the mechanisms linking increased risk for development of disease in later life in individuals born with low birth weight. Its current research addresses the role of oxidative stress in low birth weight hypertension. Increased reactive oxygen species leading to oxidative stress is related to the pathogenesis of human cardiovascular disease and hypertension. Demonstrating a direct link between oxidative stress and disease is difficult, partly due to the diversity of analytical procedures used in the field. Dr. Dr. Rajendram Rajnarayanan will collaborate with Jackson State University on his SUBPROJECT #entitled "Estrogen Receptor-Calcium Binding Protein Interfaces as Targets for the Discovery of Novel Therapeutics against Antiestrogen Resistant Breast Cancers." These studies have substantial potential benefits and are particularly important since tamoxifen-resistant breast cancers pose a significant risk. Dr. Jinghe Mao will collaborate with the University of Southern Mississippi on her SUBJECT entitled, "Lipidomic and DMA Microarray Analyses of Peripheral Blood in African-American Adults with Type II Diabetes." The USM staff specializes in microarray and metabolomics data analysis techniques. They use a wide range of industry and research standard software to analyze gene expression and metabolomics data.