A New Method for Determining Gastric Acid Output Using a Wireless Capsule

使用无线胶囊测定胃酸排出量的新方法

• 批准号: 8553604
• 负责人: Stephen Wank
• 金额: $ 30.5万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553604
• 关键词: Acidity; Acids; Aspirate substance; Buffers; Chronic; Clinic; Devices; Diagnosis; Disease; Dose; Enrollment; Evaluation; Gastric Acid; Gastroesophageal reflux disease; Gastrointestinal tract structure; Gold; Ingestion; Maintenance; Measurement; Measures; Methods; Outcome; Outpatients; Output; Patients; Pharmaceutical Preparations; Phase; Pilot Projects; Procedures; Protons; Reporting; Stomach; Symptoms; Temperature; Time; Tube; United States National Institutes of Health; Wireless Technology; capsule; gastrointestinal; interest; pill; pressure; response; tool

Acid related disorders are numerous and often require chronic treatment and maintenance. Many of these diseases are without symptoms and therefore difficult to diagnose and treat. Gastric analysis is the quantitative measurement of gastric acid output and is a critical tool for the diagnosis of acid related disorders and the ongoing assessment of therapy response. At present gastric analysis requires a technically difficult procedure, using gastric aspiration through a nasogastric tube, that is costly, invasive, and uncomfortable for patients. Recently there is introduction of the SmartPill, which is a disposable pill that measures pH, temperature, and pressure throughout the GI tract. We propose a pilot study to validate a new method of gastric analysis with the ingestion of the SmartPill with a meal of a known buffering capacity to measure both the acidity and quantity of acid output in the stomach. We will study patients with known acid related disorders to assess its usefulness in patients. Interested subjects will report to the NIH outpatient gastrointestinal clinic for evaluation. Subjects will have gastric analysis just before their next dose of anti-secretory medication using the gastric aspirate method followed by the SmartPill method. Outcomes will include a quantitative measurement of gastric acid output in unit time in patients with acid related disorders, and the assessment of acid suppression in patients treated with a variety of anti-secretory medications. We are approximately midway in our enrollment of patients in this phase of the study and therefore there are no accomplishments that can be reported at this time.

与酸相关的疾病有很多，通常需要长期治疗和维持。 其中许多疾病没有症状，因此难以诊断和治疗。 胃分析是胃酸排出量的定量测量，是诊断酸相关疾病和持续评估治疗反应的重要工具。 目前胃分析需要一个技术上困难的过程，通过鼻胃管进行胃抽吸，这对患者来说是昂贵的、侵入性的且不舒服的。 最近推出了 SmartPill，这是一种一次性药丸，可以测量整个胃肠道的 pH 值、温度和压力。 我们提出了一项试点研究，以验证一种新的胃分析方法，即在已知缓冲能力的膳食中摄入 SmartPill，以测量胃中的酸度和酸输出量。 我们将研究患有已知酸相关疾病的患者，以评估其对患者的有用性。 有兴趣的受试者将向NIH门诊胃肠诊所报告进行评估。 受试者将在下一次服用抗分泌药物之前使用胃抽吸法和 SmartPill 法进行胃部分析。结果将包括对患有胃酸相关疾病的患者单位时间内胃酸排出量的定量测量，以及对接受各种抗分泌药物治疗的患者的胃酸抑制进行评估。 在这一阶段的研究中，我们的患者入组工作大约进行到一半，因此目前还没有可以报告的成就。