Neuronal compensation for intrinsic variability and temperature perturbations.

对内在变异和温度扰动的神经元补偿。

• 批准号: 8312074
• 负责人: Tilman Kispersky
• 金额: $ 5.24万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312074
• 关键词: Action Potentials; Animals; Biology; Biomedical Engineering; Boston; Cells; Cities; Complement; Coupled; Crabs; Disease susceptibility; Doctor of Philosophy; Ensure; Exhibits; Feedback; Financial compensation; Frequencies; Funding Opportunities; Ganglia; Hybrid Cells; Hybrids; Individual; Ion Channel; Lead; Light; Mathematics; Measures; Membrane; Messenger RNA; Metric; Minnesota; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurons; Normal Range; Output; Property; Request for Applications; Shapes; Sodium Chloride; Synapses; Temperature; Testing; Therapeutic; Universities; Utah; Weight; falls; insight; nervous system disorder; prevent; research study; statistics

DESCRIPTION (provided by applicant): Tilman Kispersky Ph.D. Title: Neuronal compensation for intrinsic variability and temperature perturbations. Funding Opportunity: PA-11-113 We kindly request that this application be submitted to: National Institute for Neurological Disorders and Stroke - NINDS Referees: 1. John A. White Ph.D., Department of Bioengineering, University of Utah, Salt Lake City, Utah 2. Nancy J. Kopell Ph.D., Department of Mathematics and Statistics, Boston University, Boston, MA 3. Paul Miller Ph.D., Department of Biology, Brandeis University, Waltham, MA 4. Theoden Netoff Ph.D, Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN. PUBLIC HEALTH RELEVANCE: Variability is inherent in nervous systems and many neurological disease states are correlated with neuronal properties that fall outside of the "normal" range. Our application will help build an understanding of how normally functioning neuronal circuits can compensate for variability which may have relevance for understanding how the onset of neurological disorders is prevented. Further, our application will provide fundamental insights which will help in assessing which nervous system perturbations lead to the highest disease susceptibility or, conversely, which perturbations could have the highest medically therapeutic value.

描述（由申请人提供）：Tilman Kispersky博士标题：神经元对内在变异性和温度扰动的补偿。资助机会：PA-11-113我们恳请将此申请提交给：国家神经疾病研究所 《易经》云：“一。John A.白色博士，美国犹他州大学生物工程系，湖城，犹他州2.南希·J·科佩尔博士，波士顿大学数学与统计系，波士顿，MA 3。保罗米勒博士，生物系，布兰迪斯大学，沃尔瑟姆，MA 4。Theoden Netoff博士，明尼苏达大学生物医学工程系，明尼苏达州明尼阿波利斯市。 公共卫生相关性：变异性在神经系统中是固有的，并且许多神经疾病状态与落在“正常”范围之外的神经元特性相关。我们的应用程序将有助于建立一个正常运作的神经元回路如何补偿变异性，这可能与了解如何预防神经系统疾病的发作有关。此外，我们的应用将提供基本的见解，这将有助于评估哪些神经系统扰动导致最高的疾病易感性，或者相反，哪些扰动可能具有最高的医学治疗价值。