Learning from animals how to regenerate: multidisciplinary training programme in regenerative biology

再生-IT网络汇集了从基础研究到应用研究的所有学科，以培训再生生物学和邻近领域的下一代研究人员。虽然人类的自然再生能力是有限的，但一些动物具有显著的再生能力。例如，陆生扁虫可以从小块组织中恢复身体的所有部分，火蜥蜴可以再生失去的四肢并修复受损的眼睛，斑马鱼可以再生心脏和鳍。通过识别这些不同动物模型中潜在的再生过程的共同生物学原理，我们可以了解到如何改进对人类的再生干预。目前，再生动物模型是孤立研究的，阻止了这种共享机制的发现，而再生-IT网络填补了这一空白。由Regenerate-IT培训的ESRS将获得对再生生物学基础知识和再生医学研究需求的广泛而独特的了解。因此，再生信息技术网络包括致力于扁虫、线虫、甲壳类、两栖动物和斑马鱼等再生模式生物的科学家；致力于小鼠和人类模型的干细胞科学家；在翻译研究和临床试验方面拥有令人印象深刻的记录和经验的科学家；以及基因组学、单细胞测序、成像和药物筛选等关键技术方面的专家。再生-IT将通过研究、借调到其他实验室、联盟会议和涵盖广泛主题的研讨会来培训10名ESRS和1名相关博士研究员。除了巩固欧洲在再生生物学方面的优势，并培养一批能够进行跨学科研究的下一代科学家外，再生-IT还将结合和提供理论和技术突破，并推动再生生物学和医学的前沿。

The REGENERATE-IT Network brings together a full spectrum of disciplines - from fundamental to applied research - to train the next generation of researchers in regenerative biology and adjacent fields. While the natural regenerative ability of humans is limited, some animals have remarkable regenerative capacity. For example, planarian flatworms can restore all body parts from small pieces of tissue, salamanders can grow back lost limbs and repair damaged eyes, and zebrafish can regenerate their heart and fins. By identifying the common biological principles underlying the regenerative processes in these different animal models, we can learn a great deal on how to improve regenerative interventions in humans. Currently, regenerative animal models are studied in isolation, preventing the discovery of such shared mechanisms, and the REGENERATE-IT Network fills this gap. ESRs trained by REGENERATE-IT will obtain a broad and unique understanding of the fundamentals of regenerative biology and of the needs of research in regenerative medicine. The REGENERATE-IT Network therefore includes scientists working on regenerative model organisms such as flatworms, cnidarians, crustaceans, amphibians and zebrafish; stem cell scientists working on mouse and human models; scientists with impressive track records in translational research and experience with clinical trials; and experts in key technologies such as genomics, single cell sequencing, imaging and drug screening. REGENERATE-IT will train 10 ESRs and 1 associated doctoral researcher through research, secondments to other laboratories, consortium meetings, and workshops covering a wide range of topics. In addition to consolidating European strengths in regenerative biology, and training a cohort of next-generation scientists capable of cross-disciplinary research, REGENERATE-IT will combine and deliver theoretical and technological breakthroughs, and advance the frontiers of regenerative biology and medicine.