Learning from animals how to regenerate: multidisciplinary training programme in regenerative biology

向动物学习如何再生：再生生物学的多学科培训计划

• 批准号: EP/X030350/1
• 负责人: Enrique Amaya
• 金额: $ 33.8万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX030350%2F1
• 关键词: Learning; animals; how; regenerate; multidisciplinary

The REGENERATE-IT Network brings together a full spectrum of disciplines - from fundamental to applied research - to train the next generation of researchers in regenerative biology and adjacent fields. While the natural regenerative ability of humans is limited, some animals have remarkable regenerative capacity. For example, planarian flatworms can restore all body parts from small pieces of tissue, salamanders can grow back lost limbs and repair damaged eyes, and zebrafish can regenerate their heart and fins. By identifying the common biological principles underlying the regenerative processes in these different animal models, we can learn a great deal on how to improve regenerative interventions in humans. Currently, regenerative animal models are studied in isolation, preventing the discovery of such shared mechanisms, and the REGENERATE-IT Network fills this gap. ESRs trained by REGENERATE-IT will obtain a broad and unique understanding of the fundamentals of regenerative biology and of the needs of research in regenerative medicine. The REGENERATE-IT Network therefore includes scientists working on regenerative model organisms such as flatworms, cnidarians, crustaceans, amphibians and zebrafish; stem cell scientists working on mouse and human models; scientists with impressive track records in translational research and experience with clinical trials; and experts in key technologies such as genomics, single cell sequencing, imaging and drug screening. REGENERATE-IT will train 10 ESRs and 1 associated doctoral researcher through research, secondments to other laboratories, consortium meetings, and workshops covering a wide range of topics. In addition to consolidating European strengths in regenerative biology, and training a cohort of next-generation scientists capable of cross-disciplinary research, REGENERATE-IT will combine and deliver theoretical and technological breakthroughs, and advance the frontiers of regenerative biology and medicine.

再生it网络汇集了从基础研究到应用研究的全方位学科，以培养再生生物学和邻近领域的下一代研究人员。虽然人类的自然再生能力是有限的，但一些动物却具有显著的再生能力。例如，涡虫可以从小块组织中恢复所有身体部位，蝾螈可以长出失去的四肢并修复受损的眼睛，斑马鱼可以再生心脏和鳍。通过识别这些不同动物模型中再生过程的共同生物学原理，我们可以学到很多关于如何改善人类再生干预的知识。目前，再生动物模型的研究是孤立的，无法发现这种共享机制，而再生it网络填补了这一空白。REGENERATE-IT培训的esr将获得对再生生物学基础和再生医学研究需求的广泛而独特的理解。因此，再生it网络包括研究可再生模式生物的科学家，如扁形虫、刺胞动物、甲壳类动物、两栖动物和斑马鱼；研究小鼠和人类模型的干细胞科学家；在转化研究和临床试验方面有着令人印象深刻的记录的科学家；在基因组学、单细胞测序、成像和药物筛选等关键技术方面拥有专家。REGENERATE-IT将通过研究、借调到其他实验室、联盟会议和涵盖广泛主题的研讨会，培训10名ESRs和1名相关博士研究员。除了巩固欧洲在再生生物学方面的优势，并培养一批能够进行跨学科研究的下一代科学家外，REGENERATE-IT还将结合并提供理论和技术突破，并推进再生生物学和医学的前沿。