Preparing Trainees in Neurology and Neurosurgery for Academic Research Careers

项目描述：许多学术神经科医生和神经外科医生注意到，在过去十年中，有兴趣从事学术医学事业的住院医师项目的受训人数呈下降趋势。这可能会对神经生物学的基础和应用研究的未来产生不利影响，特别是在神经科学新知识的产生方面；(b)理解基础神经科学和临床医学之间的关系；(c)开发诊断和治疗神经系统疾病的工具。我们的前提是，同样受过临床神经病学或神经外科训练的神经科学家和流行病学家，代表着我们对未来发展和转化知识以扩大临床神经科学治疗选择的最大希望。该申请旨在为芝加哥大学的神经病学和神经外科住院医生提供组织结构和教育计划，培训他们日常的研究行为，道德考虑导致诚实的科学，尊重人类和动物，实验设计和统计分析导致具有影响力的可解释结果，撰写包含重要问题和明确回答方法的拨款提案。将根据确定合适的导师和制定有前途的研究计划，向选定的住院医师提供研究培训。在研究教育的第一阶段，神经内科住院医师将在他们的PGY3和PGY4年期间在临床或基础神经科学实验室进行6-12个月的指导研究。神经外科住院医师将在他们的PGY4年期间进行12个月的指导研究。第二阶段的研究训练将在神经病学奖学金年或神经外科住院医师的PGY5年进行。在第一阶段，每周一次的晚间研讨会课程将涵盖实验设计、研究实施和伦理以及生物统计学等问题。为期一年的论文写作研讨会课程和四分之一的负责任的研究行为课程，以及选修的神经科学和/或流行病学课程将伴随第二阶段的研究经历。所有参与者预计将有一份NIH研究申请，可能是K08或K23申请，在第二阶段结束时完成。

DESCRIPTION (provided by applicant): Program Description: Many academic neurologists and neurosurgeons have noted a downward trend over the past decade in the numbers of trainees in residency programs who are interested in pursuing careers in academic medicine. This could adversely affect the future of basic and applied research in neurobiology, particularly with respect to (a) generation of new knowledge in the neurosciences; (b) understanding the relationships between basic neuroscience and clinical medicine; and (c) development of tools for diagnosis and treatment of diseases of the nervous system. It is our premise that neuroscientists and epidemiologists, also trained in clinical neurology or neurosurgery, represent our best hope for the future in developing and translating knowledge to expand treatment options in clinical neuroscience. This application proposes to develop an organizational structure and educational program for training neurology and neurosurgery residents at The University of Chicago in the day-to-day conduct of research, the ethical considerations that lead to honest science that is respectful of humans and animals, experimental design and statistical analysis that lead to interpretable results with impact, and the writing of grant proposals that contain important questions and clearly stated methods of answering them. Research training will be offered to select residents based on identification of an appropriate mentor and development of a promising research proposal. During a first phase of research education, neurology residents will perform 6-12 months of mentored research in a clinical or basic neuroscience laboratory within their PGY3 and PGY4 years. Neurosurgery residents will perform 12 months of mentored research during their PGY4 year. The second phase of research training will occur during the neurology fellowship years or the PGY5 year of the neurosurgery residency. A weekly evening seminar course during phase I will cover issues of experimental design, research implementation and ethics, and biostatistics. A year-long seminar course in grant-writing and a one-quarter course in the responsible conduct of research, accompanied by optional neuroscience and/or epidemiology coursework will accompany the Phase II research experience. All participants are expected to have an NIH research application, probably a K08 or K23 application, completed by the end of Phase II. Public Health Relevance: The recent downward trend in the numbers of neurological and neurosurgical trainees entering academic medicine could adversely affect the development of new knowledge in the neurosciences and the development of new tools for diagnosis and treatment of diseases of the nervous system. We aim to ameliorate this situation by teaching trainees in clinical neurology and neurosurgery the principles, practices, and ethics of effective research.