Project 2 - neurotransgenic core - Neuroscience Infrastructure at Duke University

项目 2 - 神经转基因核心 - 杜克大学神经科学基础设施

• 批准号: 8374504
• 负责人: Guoping Feng
• 金额: $ 58.06万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8374504
• 关键词: Adult; Alleles; Animal Model; Area; Cancer Center; Center Core Grants; Complex; Development; Disease; Effectiveness; Environment; Equipment; Extramural Activities; Fostering; Funding; Genes; Genetic; Genetically Engineered Mouse; Genie; Genome; Genomics; Human; Human Genome; Improve Access; Individual; Institutes; Interdisciplinary Study; Ion Channel; Joints; Knock-in Mouse; Knockout Mice; Laboratories; Lead; Light; Medicine; Modeling; Molecular; Mus; National Institute of Neurological Disorders and Stroke; Nervous System Physiology; Nervous system structure; Neurons; Neurosciences; Neurosciences Research; Pathway interactions; Physiological; Population; Predisposition; Proteins; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science Policy; Seeds; Services; Susceptibility Gene; Synapses; Technology; Time; Tissues; Transgenic Mice; Universities; Wages; base; cell type; cost effective; design; gene function; gene replacement; genetic analysis; genetic manipulation; human disease; improved; in vivo; interdisciplinary approach; mouse genome; operation; overexpression; tool; translational neuroscience

In this application for an NINDS Center Core Grant, we seek support for a Neurotransgenic core laboratory at Duke University. This core provides powerful tools for studying the nervous system, where the vast diversity of cell types and synaptic connections require tools that exceed those needed to study simpler, more homogenous tissues. This core will support individual neuroscience research projects by providing necessary resources and performing required services that would be difficult or impractical to provide in individual labs. Institutional commitments of space and seed funds for equipment and salaries have already been obtained and have enabled the creation of this core within the past two years, the understanding being that extramural support would be obtained for their continued support. This core will enrich the effectiveness of ongoing NINDS-supported research at Duke, promote new directions for both basic and translational neuroscience research, and foster a cooperative and interactive research environment through which multidisciplinary approaches to neuroscience problems and joint research efforts will be stimulated. Moreover, this provides a cost-effective way for investigators to exploit cutting-edge, specialized technologies that would be difficult to setup or justify for an individual laboratory. This core has been developed in partnership with other administrative units within Duke University including the Cancer Center. This core will be utilized by neuroscientists residing in multiple departments, thereby fostering a cooperative and interactive research environment. This core represents a substantial infrastructure support for genetic analysis in support of the neurosciences.

在NINDS中心核心资助的申请中，我们寻求对神经转基因核心的支持。 杜克大学的实验室。这个核心为研究神经系统提供了强大的工具， 细胞类型和突触连接的巨大多样性需要的工具超过了所需的工具， 来研究更简单更同质的组织这个核心将支持个人的神经科学研究 提供必要的资源和执行所需的服务，这将是困难的， 在单个实验室中提供是不切实际的。空间和种子基金的机构承诺 设备和工资已经获得，并已使这一核心内的创建 在过去的两年里，我们的理解是，将获得校外支持，为他们的 继续支持。这一核心将丰富正在进行的NINDS支持的研究的有效性， 杜克，促进基础和转化神经科学研究的新方向， 合作和互动的研究环境，通过多学科方法， 神经科学问题和联合研究的努力将受到刺激。此外，这提供了一个 调查人员利用尖端专业技术的成本效益高的方式， 难以为单个实验室设置或证明。这一核心是与以下机构合作开发的： 杜克大学内的其他行政单位，包括癌症中心。这个核心将是 由居住在多个部门的神经科学家使用，从而促进了合作， 交互式研究环境。这个核心代表了遗传学的实质性基础设施支持， 支持神经科学的分析。