Testing the efficacy of a novel intervention for minimally verbal children with

测试一种新颖的干预措施对语言能力极差的儿童的有效性

基本信息

项目摘要

Although up to 30% of individuals with ASD are minimally verbal, extremely few interventions can reliably produce significant improvements in speech output. Recently, our laboratory has developed Auditory-Motor Mapping Training (AMMT), a novel intonation-based intervention, which aims to facilitate speech output in minimally verbal children with ASD. This intervention involves the mapping of sounds to oral articulatory actions through intonation and bimanual motor activities. AMMT is built upon the musical strengths and preferences that have been observed in these children. Furthermore, associating sounds with actions engages an auditory-motor network of brain regions important for speech that has been reported to be dysfunctional in ASD. The overall aim of the study is to compare the efficacy of AMMT to that of a control therapy (CT) in facilitating speech output in a randomized controlled trial (RCT). To examine whether the core components of AMMT are responsible for the treatment effects, CT will omit the intonation and motor components. The accuracy of each child's speech output will be assessed multiple times before, during, and after treatment by independent coders. Our overall aim will also be complemented by two additional aims, in which we will examine whether frequency of AMMT affects treatment outcome, and whether pre-existing variability in language-related pathways and functional connections correlate with outcome, and is changed after treatment. Based on our preliminary data, we hypothesize that: (1) compared to CT, AMMT will result in significantly greater improvements in the accuracy of consonant and vowel productions, with generalization to items that are not trained during the therapy,and more appropriate words after therapy, (2) greater improvements will be observed in individuals who undergo higher frequency (compared to lower frequency) of AMMT, (3) baseline behavioral measures (e.g., cognitive, speech praxis, joint attention abilities) will be related to the degree of speech improvements in both AMMT and CT, and (4) the degree of variability infunctional and structural brain connections will be related to AMMT treatment outcome, and (5) intensive AMMT treatment will lead to increased functional connections in the auditory-motor network. By using a combination of behavioral and brain imaging measures, the proposed study will examine the efficacy of a novel intervention, and enhance our understanding of the underlying neural mechanisms that underlie the therapy effects.
尽管高达30%的ASD患者的语言能力极低,但极少的干预措施可以可靠地显著改善语言输出。最近,我们的实验室开发了听觉-运动映射训练(AMMT),这是一种新的基于语调的干预,旨在促进ASD患儿的语言输出。这种干预包括将声音映射到口头发音

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

GOTTFRIED SCHLAUG其他文献

GOTTFRIED SCHLAUG的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('GOTTFRIED SCHLAUG', 18)}}的其他基金

Imaging the Neural Effects of Transcranial Direct Current Stimulation
经颅直流电刺激的神经效应成像
  • 批准号:
    10227550
  • 财政年份:
    2020
  • 资助金额:
    $ 37.76万
  • 项目类别:
CALLOSAL THICKNESS IN MUSICIANS
音乐家的胼胝体厚度
  • 批准号:
    8363469
  • 财政年份:
    2011
  • 资助金额:
    $ 37.76万
  • 项目类别:
CALLOSAL THICKNESS IN MUSICIANS
音乐家的胼胝体厚度
  • 批准号:
    8171146
  • 财政年份:
    2010
  • 资助金额:
    $ 37.76万
  • 项目类别:
CALLOSAL THICKNESS IN MUSICIANS
音乐家的胼胝体厚度
  • 批准号:
    7955780
  • 财政年份:
    2009
  • 资助金额:
    $ 37.76万
  • 项目类别:
Behavioral and Neural Correlates of Melodic Intonation Therapy
旋律语调疗法的行为和神经相关性
  • 批准号:
    7859440
  • 财政年份:
    2009
  • 资助金额:
    $ 37.76万
  • 项目类别:
Behavioral and Neural Correlates of Melodic Intonation Therapy
旋律语调疗法的行为和神经相关性
  • 批准号:
    8209182
  • 财政年份:
    2008
  • 资助金额:
    $ 37.76万
  • 项目类别:
Neural Control of Vocal Production in Tone-Deafness
音聋发声的神经控制
  • 批准号:
    7989117
  • 财政年份:
    2008
  • 资助金额:
    $ 37.76万
  • 项目类别:
Behavioral and Neural Correlates of Melodic Intonation Therapy
旋律语调疗法的行为和神经相关性
  • 批准号:
    7369931
  • 财政年份:
    2008
  • 资助金额:
    $ 37.76万
  • 项目类别:
Neural Control of Vocal Production in Tone-Deafness
音聋发声的神经控制
  • 批准号:
    8374383
  • 财政年份:
    2008
  • 资助金额:
    $ 37.76万
  • 项目类别:
Behavioral and Neural Correlates of Melodic Intonation Therapy
旋律语调疗法的行为和神经相关性
  • 批准号:
    7547020
  • 财政年份:
    2008
  • 资助金额:
    $ 37.76万
  • 项目类别:

相似海外基金

Life outside institutions: histories of mental health aftercare 1900 - 1960
机构外的生活:1900 - 1960 年心理健康善后护理的历史
  • 批准号:
    DP240100640
  • 财政年份:
    2024
  • 资助金额:
    $ 37.76万
  • 项目类别:
    Discovery Projects
Development of a program to promote psychological independence support in the aftercare of children's homes
制定一项计划,促进儿童之家善后护理中的心理独立支持
  • 批准号:
    23K01889
  • 财政年份:
    2023
  • 资助金额:
    $ 37.76万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Integrating Smoking Cessation in Tattoo Aftercare
将戒烟融入纹身后护理中
  • 批准号:
    10452217
  • 财政年份:
    2022
  • 资助金额:
    $ 37.76万
  • 项目类别:
Integrating Smoking Cessation in Tattoo Aftercare
将戒烟融入纹身后护理中
  • 批准号:
    10670838
  • 财政年份:
    2022
  • 资助金额:
    $ 37.76万
  • 项目类别:
Aftercare for young people: A sociological study of resource opportunities
年轻人的善后护理:资源机会的社会学研究
  • 批准号:
    DP200100492
  • 财政年份:
    2020
  • 资助金额:
    $ 37.76万
  • 项目类别:
    Discovery Projects
Creating a National Aftercare Strategy for Survivors of Pediatric Cancer
为小儿癌症幸存者制定国家善后护理策略
  • 批准号:
    407264
  • 财政年份:
    2019
  • 资助金额:
    $ 37.76万
  • 项目类别:
    Operating Grants
Aftercare of green infrastructure: creating algorithm for resolving human-bird conflicts
绿色基础设施的善后工作:创建解决人鸟冲突的算法
  • 批准号:
    18K18240
  • 财政年份:
    2018
  • 资助金额:
    $ 37.76万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Development of an aftercare model for children who have experienced invasive procedures
为经历过侵入性手术的儿童开发善后护理模型
  • 批准号:
    17K12379
  • 财政年份:
    2017
  • 资助金额:
    $ 37.76万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of a Comprehensive Aftercare Program for children's self-reliance support facility
为儿童自力更生支持设施制定综合善后护理计划
  • 批准号:
    17K13937
  • 财政年份:
    2017
  • 资助金额:
    $ 37.76万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Project#2 Extending Treatment Effects Through an Adaptive Aftercare Intervention
项目
  • 批准号:
    8742767
  • 财政年份:
    2014
  • 资助金额:
    $ 37.76万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了