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Neural Control of Vocal Production in Tone-Deafness

音聋发声的神经控制

基本信息

批准号：
8374383
负责人：
GOTTFRIED SCHLAUG
金额：
$ 32.89万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-12-01 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8374383
关键词：
Address Affect Anatomy Area Attention Auditory Auditory Perception Auditory area Behavior assessment Behavioral Brain Brain Mapping Brain imaging Brain region Characteristics Communication Control Groups Coupling Data Diffusion Magnetic Resonance Imaging Disabled Persons Disease Electrical Stimulation of the Brain Engineering Event-Related Potentials Feedback Functional Imaging Functional disorder Genetic Goals Health Hearing Hearing Impaired Persons Image Analysis Impairment Individual Inferior Inferior frontal gyrus Interdisciplinary Study Joints Left Lesion Location Maps Measures Methods Modeling Motor Motor Cortex Music Neural Network Simulation Neurosciences Participant Pathway interactions Pitch Discrimination Pitch Perception Play Process Production Psychophysics Publishing Qualifying Reaction Reaction Time Relative (related person)Research Role Sampling Simulate Speech Speech Disorders Speech Perception Speech Sound Superior temporal gyrus Syndrome System Techniques Temporal Lobe Testing auditory feedback base blood oxygenation level dependent response deafness frontal lobe gray matter improved in vivo innovation insight interest morphometry nervous system disorder neural model neuroimaging neuromechanism neuroregulation programs relating to nervous system research study sound theories virtual vocal control

项目摘要

DESCRIPTION (provided by applicant): Although we all know one or more individuals who can't sing in tune, the neural correlates of this disorder and what it might reveal about models of communication control remain elusive. In addition to an inability to sing in tune, one characteristic marker of tone-deafness is an abnormally large psychophysical pitch discrimination threshold of more than one semitone. The inability to discriminate fine pitch differences may be an epiphenomenon of the disorder, or it could be related to the presumed auditory-motor dysfunction that underlies disabled production of vocal pitch. Pilot and previous data from morphometric, functional imaging, and Event- Related Potential (ERP) studies point towards functional and structural abnormalities in regions involved in auditory feedback control and sound-motor mapping, rather than dysfunctions in primary auditory cortex. In considering that the inability to sing might be reflective of problems in auditory-motor integration including feedforward and feedback control mechanisms, the present theoretical framework allows us to generalize existing models of speech perception and production to the domain of singing as an instance of "intoned-speech". Our general hypothesis is that tone-deafness is a result of dysfunction in a network of brain regions involved in auditory feedback and feedforward control of vocal pitch production. We plan to test this hypothesis by first identifying the behavioral and neural substrates of tone-deafness. By combining neuroimaging and psychophysical experiments of pitch production, including the use of pitch- shifted auditory feedback, we will test the neural mechanisms responsible for auditory feedback control and sound-motor mapping as well as the interaction of these two systems (Aim 1). We will then reverse-engineer the perceptuomotor pathway by creating temporary regional dysfunctions using a new method of non-invasive brain stimulation (transcranial direct current stimulation - TDCS) (Aim 2). Based on pilot pitch production results, brain stimulation can temporarily induce tone-deafness in normal individuals, thus allowing us to assess our regional hypotheses using psychophysical measures that have been evaluated in experiments from the first aim. Examining the neural correlates of tone-deafness and creating a tone-deaf equivalent in normal subjects will offer new insights into the interactions of auditory and motor systems in the brain in normal and disordered speech as well as in non-speech communication.

描述（由申请人提供）：尽管我们都知道一个或多个唱歌不准的人，但这种疾病的神经相关性以及它可能揭示的沟通控制模型的内容仍然难以捉摸。除了无法唱准音之外，音聋的一个特征标志是超过一个半音的异常大的心理物理音高辨别阈值。无法区分细微的音调差异可能是该疾病的一个附带现象，或者可能与推测的听觉运动功能障碍有关，而听觉运动功能障碍是音调产生障碍的基础。来自形态测量、功能成像和事件相关电位（ERP）研究的试点和先前数据表明，涉及听觉反馈控制和声音运动映射的区域存在功能和结构异常，而不是初级听觉皮层的功能障碍。考虑到无法唱歌可能反映了听觉运动整合中的问题，包括前馈和反馈控制机制，目前的理论框架允许我们将现有的语音感知和产生模型推广到歌唱领域，作为“有调语音”的一个实例。我们的一般假设是，音聋是涉及听觉反馈和音调产生的前馈控制的大脑区域网络功能障碍的结果。我们计划首先确定音聋的行为和神经基础来检验这一假设。通过结合音调产生的神经影像学和心理物理学实验，包括使用音调变换的听觉反馈，我们将测试负责听觉反馈控制和声音运动映射的神经机制以及这两个系统的相互作用（目标 1）。然后，我们将使用一种新的非侵入性脑刺激方法（经颅直流电刺激 - TDCS）产生暂时的区域功能障碍，对感知运动通路进行逆向工程（目标 2）。根据飞行员音调产生的结果，大脑刺激可以暂时引起正常人的音聋，从而使我们能够使用从第一个目标开始的实验中评估的心理物理措施来评估我们的区域假设。检查音聋的神经相关性并在正常受试者中创建音聋等效物将为正常和紊乱言语以及非言语交流中大脑中听觉和运动系统的相互作用提供新的见解。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Absolute Pitch and Synesthesia: Two Sides of the Same Coin? Shared and Distinct Neural Substrates of Music Listening.

DOI：
发表时间：
2012
期刊：
ICMPC : Proceedings. International Conference on Music Perception and Cognition
影响因子：
0
作者：
P. Loui;Anna P. Zamm;G. Schlaug
通讯作者：
P. Loui;Anna P. Zamm;G. Schlaug

White matter integrity in right hemisphere predicts pitch-related grammar learning.