Dynamics of Spoken Word Comprehension in Aphasia

项目概要/摘要 失语症是一种与中风有关的语言处理障碍， 在美国的人。人类活动如此依赖于口头交流， 口语处理的损伤，例如失语症，可能是毁灭性的。此外 功能障碍，如无法工作，语言障碍也会导致社会 隔离及其对身心健康的负面影响。因为 语言处理需要许多不同的认知能力，失语症可能有许多 不同的潜在原因，每个失语症患者可能有微妙不同的损害。 设计有效的康复策略取决于我们对疾病性质的理解。 因此，这项建议的重点是使用行为实验， 用计算机模拟方法建立失语症口语词的形式理论 理解力拟议的实验将调查语音，语义， 大量不同类型失语症患者文字处理的认知控制方面 和未受损的控制参与者使用行为和眼动跟踪措施。这些 这些措施将为失语症的文字处理动态提供新的见解。 计算建模将用于开发和测试文字处理的正式帐户 失语症的缺陷随着对失语症的深层原因有了更好的理解 损伤和失语症的正式模型，更有效的康复策略， 开发

Project Summary/Abstract Aphasia is a stroke-related disability of language processing that affects about one million people in the United States. Human activity is so dependent on spoken communication that impairments of spoken language processing, such as aphasia, can be devastating. In addition to functional impairments such as inability to work, language impairments can also cause social isolation and its consequent negative outcomes on mental and physical health. Because language processing calls on many different cognitive faculties, aphasia may have many different underlying causes and each aphasic individual may have a subtly different impairment. Designing effective rehabilitation strategies depends on our understanding of the nature of the impairment, thus, the focus of this proposal is on using behavioral experiments and computational modeling methods to develop a formal theory of aphasic spoken word comprehension. The proposed experiments will investigate phonological, semantic, and cognitive control aspects of word processing in a large and diverse set of aphasic individuals and unimpaired control participants using behavioral and eye tracking measures. These measures will provide new insights into the dynamics of word processing in aphasia. Computational modeling will be used to develop and test formal accounts of word processing deficits in aphasia. With a better understanding of the underlying causes of aphasic language impairments and a formal model of aphasia, more effective rehabilitation strategies can be developed.