Dynamics of Spoken Word Comprehension in Aphasia

项目摘要/摘要 失语症是一种与中风相关的语言处理障碍，影响约100万人 在美国的人们。人类的活动是如此依赖于口头交流，以至于 口语处理的障碍，如失语症，可能是毁灭性的。此外 除了无法工作等功能障碍外，语言障碍也会导致社交 孤立及其对身心健康的负面影响。因为 语言处理需要许多不同的认知能力，失语症可能有许多 不同的潜在原因和每个失语症患者可能有微妙的不同的损害。 制定有效的康复策略取决于我们对康复本质的理解 因此，这项建议的重点是使用行为实验和 发展失语症口语形式化理论的计算建模方法 理解。拟议的实验将调查语音、语义和 大量不同失语症个体对文字处理的认知控制 以及使用行为和眼球跟踪测量的未受损的对照组参与者。这些 这些措施将为失语症患者的文字处理动态提供新的见解。 将使用计算建模来开发和测试文字处理的正式帐户 失语症的缺陷。更好地理解失语症的根本原因 和失语症的正式模型，更有效的康复策略可以 发展起来的。

Project Summary/Abstract Aphasia is a stroke-related disability of language processing that affects about one million people in the United States. Human activity is so dependent on spoken communication that impairments of spoken language processing, such as aphasia, can be devastating. In addition to functional impairments such as inability to work, language impairments can also cause social isolation and its consequent negative outcomes on mental and physical health. Because language processing calls on many different cognitive faculties, aphasia may have many different underlying causes and each aphasic individual may have a subtly different impairment. Designing effective rehabilitation strategies depends on our understanding of the nature of the impairment, thus, the focus of this proposal is on using behavioral experiments and computational modeling methods to develop a formal theory of aphasic spoken word comprehension. The proposed experiments will investigate phonological, semantic, and cognitive control aspects of word processing in a large and diverse set of aphasic individuals and unimpaired control participants using behavioral and eye tracking measures. These measures will provide new insights into the dynamics of word processing in aphasia. Computational modeling will be used to develop and test formal accounts of word processing deficits in aphasia. With a better understanding of the underlying causes of aphasic language impairments and a formal model of aphasia, more effective rehabilitation strategies can be developed.