Sex Differences and Progesterone Effects on Impulsivity and Smoking Cessation

性别差异和黄体酮对冲动和戒烟的影响

基本信息

  • 批准号:
    8366480
  • 负责人:
  • 金额:
    $ 13.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-08-01 至 2017-07-31
  • 项目状态:
    已结题

项目摘要

Compared to men, women are at an increased risk of smoking-related morbidity and mortality. Sex hormones have been implicated in both the animal and clinical literature as having an effect on addictive behaviors. In clinical literature on tobacco use, our work along with others has demonstrated that the luteal phase (high progesterone) is associated with decreased smoking-related symtomatology and improved smoking cessation outcomes. These data suggest that progesterone (PRO) may enhance smoking cessation. Impulsivity is another factor that may impact smoking behavior as smokers are typically more impulsive than non-smokers. Further, among those who attempt to quit smoking, those who relapse have higher levels of impulsivity. Interestingly, clinical data indicates the association between impulsivity and smoking behavior may vary by sex. Further, data from the animal literature suggest that PRO may reduce impulsive behavior. Therefore, the objective of this project is to examine the interplay of PRO, impulsivity and sex differences in smoking cessation. Specifically, our primary aim is to investigate sex differences in the effect of exogenous PRO compared to placebo on impulsivity and smoking cessation. We will address this specific aim by conducting a double-blind randomized smoking cessation trial including female and male smokers randomized into one to either active or placebo PRO. The design (paralleling Project II) provides a unique opportunity to delineate sex differences and PRO effects in smoking cessation. If our hypotheses are confirmed, the results of this study could directiy advance the literature on the role of sex hormones in addictive behaviors. Further, this study has the potential to inform new and innovative smoking cessation intervention treatments via the delivery of exogenous hormones. RELEVANCE (See instructions): Despite much effort, there are not yet highly effective approved medications for the direct treatment of cocaine and nicotine dependence. This SCOR will carry out interdisciplinary and translational investigations to identify pharmacological interventions targeting behaviors impaired in nicotine and cocaine dependent subjects to enhance the effectiveness of existing behavioral treatments for addiction.
与男子相比,妇女与吸烟有关的发病率和死亡率的风险更高。性 激素在动物和临床文献中都有涉及, 行为。在烟草使用的临床文献中,我们的工作沿着其他人已经证明, 阶段(高孕酮)与吸烟相关的症状学降低有关, 戒烟的结果。这些数据表明,孕酮(PRO)可能会增加吸烟 停止冲动性是另一个可能影响吸烟行为的因素,因为吸烟者通常更容易吸烟。 比不吸烟的人更容易冲动。此外,在那些试图戒烟的人中,那些复发的人 更高水平的冲动。有趣的是,临床数据表明冲动性与 吸烟行为可能因性别而异。此外,来自动物文献的数据表明,PRO可以减少 冲动行为因此,本项目的目的是研究PRO,冲动性 戒烟的性别差异。具体来说,我们的主要目的是调查性别差异, 与安慰剂相比,外源性PRO对冲动和戒烟的影响。我们将解决 通过进行一项包括女性和男性的双盲随机戒烟试验, 吸烟者随机分为活性或安慰剂PRO组。该设计(与项目II并行)提供了一个 独特的机会,描绘性别差异和PRO戒烟的影响。如果我们的假设 证实,这项研究的结果可以直接推进性激素在 成瘾行为此外,这项研究有可能为新的和创新的戒烟提供信息 通过输送外源性激素进行干预治疗。 相关性(参见说明): 尽管做了很多努力,但目前还没有高效的批准药物用于直接治疗 可卡因和尼古丁依赖。该SCOR将开展跨学科和翻译研究 确定针对尼古丁和可卡因依赖者中受损行为的药理学干预措施, 主题,以提高现有的成瘾行为治疗的有效性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Marilyn E. Carroll其他文献

Sex differences in reinstatement of cocaine-seeking in rats after acute treatment of progesterone and atomoxetine
  • DOI:
    10.1016/j.drugalcdep.2015.07.585
  • 发表时间:
    2015-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Natashia Swalve;Natalie Zlebnik;Heather Veglahn;Marilyn E. Carroll
  • 通讯作者:
    Marilyn E. Carroll
Long-term blockade of cocaine use and locomotor activation in rats by an adenoviral vector-delivered cocaine hydrolase
  • DOI:
    10.1016/j.drugalcdep.2016.08.525
  • 发表时间:
    2017-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    John R. Smethells;Natashia Swalve;Stephen Brimijoin;Robin Parks;Marilyn E. Carroll
  • 通讯作者:
    Marilyn E. Carroll
Oral phencyclidine (PCP) self-administration in rhesus monkeys: effects of feeding conditions.
恒河猴口服苯环己哌啶(PCP)自我给药:喂养条件的影响。
Effects of dose on increased etonitazene self-administration by rats due to food deprivation
  • DOI:
    10.1007/bf00427762
  • 发表时间:
    1984-09-01
  • 期刊:
  • 影响因子:
    3.300
  • 作者:
    Marilyn E. Carroll;Irwin N. Boe
  • 通讯作者:
    Irwin N. Boe
Cocaine self-administration in male and female monkeys, treatment with progesterone and enriched environment
  • DOI:
    10.1016/j.drugalcdep.2015.07.1021
  • 发表时间:
    2015-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Marilyn E. Carroll;Molly Collins;Ben Dougen
  • 通讯作者:
    Ben Dougen

Marilyn E. Carroll的其他文献

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{{ truncateString('Marilyn E. Carroll', 18)}}的其他基金

Comparing Novel Strategies for Reducing Drug Abuse in Male and Female Rhesus Monkeys
比较减少雄性和雌性恒河猴药物滥用的新策略
  • 批准号:
    9310564
  • 财政年份:
    2016
  • 资助金额:
    $ 13.9万
  • 项目类别:
Sex Differences and Progesterone Effects on Impulsivity, Smoking & Cocaine Abuse
性别差异和黄体酮对冲动、吸烟的影响
  • 批准号:
    9483407
  • 财政年份:
    2012
  • 资助金额:
    $ 13.9万
  • 项目类别:
Sex Differences and Progesterone Effects on Impulsivity, Smoking & Cocaine Abuse
性别差异和黄体酮对冲动、吸烟的影响
  • 批准号:
    8343994
  • 财政年份:
    2012
  • 资助金额:
    $ 13.9万
  • 项目类别:
Sex Differences and Progesterone Effects on Impulsivity, Smoking & Cocaine Abuse
性别差异和黄体酮对冲动、吸烟的影响
  • 批准号:
    8517075
  • 财政年份:
    2012
  • 资助金额:
    $ 13.9万
  • 项目类别:
Sex Differences and Progesterone Effects on Impulsivity, Smoking & Cocaine Abuse
性别差异和黄体酮对冲动、吸烟的影响
  • 批准号:
    8708809
  • 财政年份:
    2012
  • 资助金额:
    $ 13.9万
  • 项目类别:
PRECLINICAL STUDIES:ANIMAL MODELS OF IMPULSIVITY AND ADDICTION
临床前研究:冲动和成瘾的动物模型
  • 批准号:
    7647108
  • 财政年份:
    2008
  • 资助金额:
    $ 13.9万
  • 项目类别:
Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
青春期、冲动和药物滥用:性/激素
  • 批准号:
    7919462
  • 财政年份:
    2007
  • 资助金额:
    $ 13.9万
  • 项目类别:
Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
青春期、冲动和药物滥用:性/激素
  • 批准号:
    7501378
  • 财政年份:
    2007
  • 资助金额:
    $ 13.9万
  • 项目类别:
Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
青春期、冲动和药物滥用:性/激素
  • 批准号:
    8128724
  • 财政年份:
    2007
  • 资助金额:
    $ 13.9万
  • 项目类别:
PRECLINICAL STUDIES:ANIMAL MODELS OF IMPULSIVITY AND ADDICTION
临床前研究:冲动和成瘾的动物模型
  • 批准号:
    7389925
  • 财政年份:
    2007
  • 资助金额:
    $ 13.9万
  • 项目类别:

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