The Effects of Smoking and Expectancy on ERP Measures of Attentional Bias

吸烟和期望对注意力偏差 ERP 测量的影响

• 批准号: 8269937
• 负责人: Jason D Robinson
• 金额: $ 17.84万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8269937
• 关键词: Address; Adult; Affect; Affective; Area; Association Learning; Attention; Brain; Cells; Cigarette; Clinical Trials Design; Cognitive; Cognitive Science; Cues; Data; Deception; Dependence; Development; Digit structure; Dose; Double-Blind Method; Electroencephalography; Emotional; Emotions; Environment; Equilibrium; Ethical Issues; Event-Related Potentials; Expectancy; Exposure to; Female; Gender; Grant; Instruction; Knowledge; Laboratories; Legal; Measures; Mentors; Mentorship; Methodology; Neurobiology; Nicotine; Nicotine Dependence; Patient Self-Report; Peripheral Nervous System; Pharmaceutical Preparations; Placebos; Process; Property; Psychophysiology; Reaction Time; Relapse; Research; Research Personnel; Research Training; Resources; Sampling; Scientist; Sex Characteristics; Slide; Smoke; Smoker; Smoking; Stimulus; Techniques; Technology; Tobacco use; Training; University of Texas M D Anderson Cancer Center; Woman; Work; addiction; career; craving; cue reactivity; deprivation; design; distraction; drug of abuse; expectation; experience; health disparity; human subject; indexing; information processing; men; multidisciplinary; neurobehavior; neurobehavioral; programs; public health relevance; relating to nervous system; response; skills; visual information

DESCRIPTION (provided by applicant): The focus of this proposal is to provide the applicant with the skills, experience, and mentoring to become an independent researcher with a focus on understanding the neurobehavioral determinants of nicotine dependence. The training plan outlined in this proposal will allow me to expand my skills by providing an opportunity to become proficient in the use of event-related potential (ERP) electroencephalography (EEC) techniques to study attentional and emotional mechanisms related to nicotine dependence. This work will be conducted at the University of Texas M. D. Anderson Cancer Center, where I will be mentored by distinguished scientists in the field of nicotine dependence. This multidisciplinary team will provide oversight of my research and training experiences by providing specific expertise in the areas of neurobehavior, ERP, attentional biases, and gender differences of smoking. The focus of the Research Plan is to gain a greater understanding of the attentional biases of smokers in order to expand our knowledge of how drug and affective cues help to maintain neural sensitization to drugs of abuse. The proposed study would be the first to evaluate the attentional bias of smokers using a within-subjects balanced placebo design, allowing for the separation of the effects of nicotine from the effects of smoking cues on ERP attentional response to smoking and affective cues. The specific aims of this proposal are (a) to distinguish the effects of nicotine's pharmacological properties from those resulting from learned associations on the attentional distraction by smoking and affective cues in dependent smokers, (b) to determine whether gender differences exist in the attentional distraction by smoking and affective cues, (c) to determine whether the expectation of imminent tobacco use increases the attentional distraction by smoking and affective cues, and (d) to assess whether ERP measures of attentional distraction by smoking and affective cues correlate with traditional self-reported measures of nicotine dependence, craving, and affect. PUBLIC HEALTH RELEVANCE: Smoking dependence is thought to be maintained by the brain's attentional bias towards cues in the environment that remind the dependent invidual of smoking. This study will use event-related potential (ERP) EEG technology to investigate these attentional biases and circumstances that provoke them.

描述（由申请人提供）：本提案的重点是为申请人提供技能，经验和指导，使其成为一名独立的研究人员，专注于了解尼古丁依赖的神经行为决定因素。这份提案中概述的培训计划将使我有机会熟练使用事件相关电位（ERP）脑电图（EEC）技术来研究与尼古丁依赖相关的注意力和情绪机制，从而扩大我的技能。这项工作将在德克萨斯大学安德森癌症中心进行，在那里我将受到尼古丁依赖领域的杰出科学家的指导。这个多学科团队将通过提供神经行为、ERP、注意偏差和吸烟的性别差异等领域的专业知识，监督我的研究和培训经验。研究计划的重点是更好地了解吸烟者的注意力偏差，以扩大我们对药物和情感线索如何帮助维持对药物滥用的神经敏感性的认识。拟议的研究将是第一个使用受试者内平衡安慰剂设计来评估吸烟者的注意偏倚的研究，允许将尼古丁的影响与吸烟线索对ERP对吸烟和情感线索的注意反应的影响分开。本提案的具体目的是：(a)区分尼古丁的药理学特性与后天联想对依赖吸烟者吸烟和情感线索引起的注意力分散的影响，(b)确定吸烟和情感线索引起的注意力分散是否存在性别差异，(c)确定即将使用烟草的预期是否会增加吸烟和情感线索引起的注意力分散。(d)评估吸烟引起的注意力分散和情感线索的ERP测量是否与传统的尼古丁依赖、渴望和影响的自我报告测量相关。

项目成果

Attentional bias to smoking and other motivationally relevant cues is affected by nicotine exposure and dose expectancy.

• DOI: 10.1177/0269881116642879
• 发表时间: 2016-07
• 期刊: Journal of psychopharmacology (Oxford, England)
• 作者: Robinson JD;Versace F;Engelmann JM;Cui Y;Gilbert DG;Waters AJ;Gritz ER;Cinciripini PM
• 通讯作者: Cinciripini PM

The effects of nicotine dose expectancy and motivationally relevant distracters on vigilance.

尼古丁预期剂量和动机相关的干扰物对警惕性的影响。

• DOI: 10.1037/a0035122
• 发表时间: 2014
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Robinson,JasonD;Engelmann,JefferyM;Cui,Yong;Versace,Francesco;Waters,AndrewJ;Gilbert,DavidG;Gritz,EllenR;Cinciripini,PaulM
• 通讯作者: Cinciripini,PaulM