Attentional bias to smoking and other motivationally relevant cues is affected by nicotine exposure and dose expectancy.
Attentional bias to smoking and other motivationally relevant cues is affected by nicotine exposure and dose expectancy.
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DOI：
10.1177/0269881116642879
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Cinciripini PM
中科院分区：
文献类型：
--
作者：
Robinson JD;Versace F;Engelmann JM;Cui Y;Gilbert DG;Waters AJ;Gritz ER;Cinciripini PM
我们研究了急性尼古丁剂量和预期剂量对夜间尼古丁剥夺吸烟者吸烟和情感线索注意偏倚（AB）的影响（n=51； 24名女性），使用平衡安慰剂设计，平衡给定尼古丁剂量（给定nic vs给定denic）和指示尼古丁预期剂量（告知nic vs告知denic）。在抽研究用香烟之前和之后，吸烟者完成了一项警戒性任务，在忽略间歇性吸烟、愉快的、不愉快的和中性的图片干扰的情况下，他们每连续三次按一下偶数或奇数的按钮。我们检测了事件相关电位（ERPs）对干扰物的早期后验负性（EPN）和晚期正电位（LPP）成分、对目标数字的反应时间（RT）和研究卷烟的评级。EPN对给予剂量和指导剂量均敏感，而指导剂量对LPP的影响有所缓和。放疗指标对给定剂量敏感，但对指示剂量不敏感。给定剂量对吸烟后评分的影响（例如，享受）被指示剂量所缓和。ERP的研究结果表明，尼古丁的预期效果提高了注意力，就像接受实际的尼古丁一样。
We investigated the effects of acute nicotine dose and expected dose on attentional bias (AB) to smoking and affective cues in overnight nicotine-deprived smokers (n=51; 24 women) using a balanced placebo design, which counterbalanced given nicotine dose (Given-NIC vs. Given-DENIC) with instructed nicotine dose expectancy (Told-NIC vs. Told-DENIC). Before and after smoking a study cigarette, smokers completed a vigilance task where they pressed buttons to every third consecutive even or odd digit, while ignoring intermittent smoking, pleasant, unpleasant, and neutral picture distracters. We examined the early posterior negativity (EPN) and late positive potential (LPP) components of the event-related potentials (ERPs) to the distracters, reaction time (RT) to the target digits, and ratings of the study cigarettes. The EPN was sensitive to both given and instructed nicotine dose, while the instructed dose moderated the impact of given dose for the LPP. The RT metrics were sensitive to given but not to instructed dose. The effects of given dose on ratings following cigarette smoking (e.g., enjoyment) were moderated by the instructed dose. The ERP findings suggest that the anticipated effects of nicotine improve attention much like receiving actual nicotine.
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