Superfund Metal Mixtures, Biomarkers and Neurodevelopment

Superfund 金属混合物、生物标志物和神经发育

• 批准号: 8254509
• 负责人: David C Bellinger
• 金额: $ 243.6万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-12 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8254509
• 关键词: 2 year old; Address; Advisory Committees; Age; Animals; Arsenic; Bangladesh; Basic Science; Bioinformatics; Biological; Biological Availability; Biological Markers; Biology; Birth; Boston; Candidate Disease Gene; Characteristics; Child; Child Development; Childhood; Cities; Communication; Complex; Country; DRD4 gene; Data; Developed Countries; Developing Countries; Development; Dose; Ensure; Environment; Environmental Health; Figs - dietary; Fostering; Funding; Future; Gasoline; Gene Expression; Genes; Genetic; Genetic Predisposition to Disease; Genotype; Goals; Grant; Health; Human; Human Genome; Income; Infant; Institution; Institutional Review Boards; Knowledge; Lead; Lead Poisoning; Leadership; Life; Manganese; Measures; Metal exposure; Metals; Mexico; Monitor; Movement; National Institute of Environmental Health Sciences; Neurons; Outcome; Parents; Pathway Analysis; Phase; Phenotype; Population; Prevention program; Probability; Public Health Schools; Publishing; RNA Interference; Regulation; Research; Research Personnel; Resource Sharing; Resources; Sample Size; Site; Structure; Superfund; System; Tars; Technology; Testing; Time; Toxic effect; Toxicogenomics; Translating; United States National Institutes of Health; Universities; Variant; Water; Work; base; blood lead; cohort; design; dopamine transporter; experience; gene environment interaction; genetic variant; genome wide association study; intervention program; meetings; metal poisoning; named group; neurodevelopment; neurotoxic; population based; prenatal; programs; prospective; superfund site; tool

DESCRIPTION (provided by applicant): The Administrative Core promotes intellectual activities, organization of venues for planning future research through seminars and retreats, and oversight of research and spending. This Core also provides the tools to work with institutions inside and outside of Harvard School of Public Health to leverage the potential of the Superfund Basic Research Program to translate the findings of our research and to promote research on mixtures, gene-environment interactions, and the movement of metals in the environment. The specific aims of the Administrative Core are to: Aim 1- Research- To monitor research progress, coordinate Internal Advisory Committee (Governance Committee) meetings, and foster collaborative research both within the SBRP Program and among other Harvard affiliated institutions and collaborative institutions, such as MIT; Aim 2- Communication- To foster communication between the Harvard SBRP and SBRP programs within EPA Region 1 (Dartmouth, Brown, Boston University) and agencies such as EPA, ATSDR and the Pediatric Environmental Health Subspecialty Units (PEHSUs), and to maintain close communication with the National Institute of Environmental Health Sciences; Aim 3-To provide necessary resources and fiscal oversight; Aim 4- To promote rapid dissemination of significant research findings; and Aim 5- Compliance- To ensure compliance with NIH requirements for data and resource-sharing and the human and animal institutional review board requirements PUBLIC HEALTH RELEVANCE: Core A, under Dr. Wright, will provide scientific leadership, insuring coordination and integration among projects and cores. Core A will provide administrative leadership directing the administration of research funds and maintaining compliance with all relevant federal regulations.

描述（由申请人提供）：行政核心促进智力活动，通过研讨会和务虚会组织规划未来研究的场所，以及监督研究和支出。该核心还提供了与哈佛公共卫生学院内外的机构合作的工具，以利用超级基金基础研究计划的潜力来转化我们的研究成果，并促进对混合物，基因-环境相互作用以及金属在环境中的运动的研究。目标1-研究-监督研究进展，协调内部咨询委员会（治理委员会）会议，并促进SBRP计划和其他哈佛附属机构和合作机构，如麻省理工学院之间的合作研究;目标2-沟通-促进哈佛SBRP和EPA区域1内SBRP项目之间的沟通（达特茅斯、布朗、波士顿大学）和环境保护局、美国毒物和疾病登记署和儿科环境卫生专科单位等机构，并与国家环境卫生科学研究所保持密切联系;目标3-提供必要的资源和财政监督;目标4-促进重要研究成果的迅速传播;目标5-遵守-确保遵守NIH关于数据和资源共享的要求以及人类和动物机构审查委员会的要求 公共卫生相关性：核心A，在赖特博士的领导下，将提供科学的领导，确保项目和核心之间的协调和整合。核心A将提供行政领导，指导研究基金的管理，并遵守所有相关的联邦法规。