Superfund Metal Mixtures, Biomarkers and Neurodevelopment

Superfund 金属混合物、生物标志物和神经发育

• 批准号: 8451454
• 负责人: David C Bellinger
• 金额: $ 232.64万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-12 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8451454
• 关键词: Address; Advisory Committees; Age; Animals; Arsenic; Bangladesh; Basic Science; Bioinformatics; Biological; Biological Markers; Biology; Birth; Boston; Candidate Disease Gene; Characteristics; Child; Childhood; Cities; Communication; Complex; Country; DRD4 gene; Data; Developed Countries; Developing Countries; Development; Dose; Ensure; Environment; Environmental Health; Figs - dietary; Fostering; Funding; Gasoline; Gene Expression; Genes; Genetic; Genetic Predisposition to Disease; Genotype; Goals; Grant; Health; Human; Human Genome; Income; Infant; Institution; Institutional Review Boards; Knowledge; Lead; Lead Poisoning; Leadership; Life; Manganese; Measures; Metal exposure; Metals; Mexico; Monitor; Movement; National Institute of Environmental Health Sciences; Neurons; Outcome; Parents; Pathway Analysis; Phase; Phenotype; Population; Probability; Public Health Schools; Publishing; RNA Interference; Regulation; Research; Research Personnel; Resource Sharing; Resources; Sample Size; Structure; Superfund; System; Tars; Technology; Testing; Time; Toxic effect; Toxicogenomics; Translating; United States National Institutes of Health; Universities; Variant; Water; Work; base; blood lead; cohort; design; dopamine transporter; experience; gene environment interaction; genetic variant; genome wide association study; meetings; metal poisoning; named group; neurodevelopment; neurotoxic; population based; programs; prospective; superfund site; tool

DESCRIPTION (provided by applicant): The Administrative Core promotes intellectual activities, organization of venues for planning future research through seminars and retreats, and oversight of research and spending. This Core also provides the tools to work with institutions inside and outside of Harvard School of Public Health to leverage the potential of the Superfund Basic Research Program to translate the findings of our research and to promote research on mixtures, gene-environment interactions, and the movement of metals in the environment. The specific aims of the Administrative Core are to: Aim 1- Research- To monitor research progress, coordinate Internal Advisory Committee (Governance Committee) meetings, and foster collaborative research both within the SBRP Program and among other Harvard affiliated institutions and collaborative institutions, such as MIT; Aim 2- Communication- To foster communication between the Harvard SBRP and SBRP programs within EPA Region 1 (Dartmouth, Brown, Boston University) and agencies such as EPA, ATSDR and the Pediatric Environmental Health Subspecialty Units (PEHSUs), and to maintain close communication with the National Institute of Environmental Health Sciences; Aim 3-To provide necessary resources and fiscal oversight; Aim 4- To promote rapid dissemination of significant research findings; and Aim 5- Compliance- To ensure compliance with NIH requirements for data and resource-sharing and the human and animal institutional review board requirements

描述（由申请人提供）：行政核心促进智力活动，通过研讨会和务虚会来组织规划未来研究的场所，以及对研究和支出的监督。该核心还提供了与哈佛大学公共卫生学院内外的机构合作的工具，以利用超级基金基础研究计划的潜力来转化我们的研究结果，并促进对混合物、基因-环境相互作用以及金属在环境中的移动的研究。行政核心的具体目标是： 目标 1 - 研究 - 监督研究进展，协调内部咨询委员会（治理委员会）会议，并促进 SBRP 项目内部以及其他哈佛附属机构和合作机构（如麻省理工学院）之间的合作研究；目标 2 - 沟通 - 促进哈佛 SBRP 和 EPA 1 区（达特茅斯、布朗、波士顿大学）内的 SBRP 项目与 EPA、ATSDR 和儿科环境健康亚专业单位 (PEHSU) 等机构之间的沟通，并与国家环境健康科学研究所保持密切沟通； 目标 3——提供必要的资源和财政监督； 目标 4——促进重要研究成果的快速传播；目标 5 - 合规性 - 确保符合 NIH 对数据和资源共享的要求以及人类和动物机构审查委员会的要求