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The Role of Nag-1 in colon cancer and aging

The Role of Nag-1 in colon cancer and aging
Nag-1 在结肠癌和衰老中的作用
批准号：
8535333
负责人：
KELLY INMAN
金额：
$22.56万
依托单位：
INTEGRATED LABORATORY SYSTEMS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-09-30 至 2013-09-29
来源：
https://reporter.nih.gov/project-details/8535333
关键词：
AgingAnimalsCarcinogensColon CarcinomaDietDoseFatty acid glycerol estersFemaleGDF15 geneGene ExpressionIntraperitoneal InjectionsKnock-outLeptinLongevityMalignant NeoplasmsMusObesityResistanceRoleSerumTimeWild Type Mousefeedingtumor

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英文摘要
To determine whether the NAG-Tg mice are resistant to high-fat-diet-induced obesity followed by cancer resistant, mice (NAG-Tg, knockouts and control littermates) will be fed regular chow or a high-fat diet. NAG-Tg, KO, and control mice (6-8 week old) will be treated at weekly intervals with six doses of AOM (10 mg/kg) by intraperitoneal injection. In addition, the purpose of this study is to evaluate the impact of a high fat diet on life span, serum leptin and NAG-1 levels, and gene expression in female Nag-1 mice. Wild type and NAG-1 females from lines 1377 and 1398 are being feed a diet of 10% or 60% fat.
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