The Role of Environmental Exposures of Silica via the Lung in the Manifestation o

通过肺暴露于环境中的二氧化硅在表现中的作用

• 批准号: 8535332
• 负责人: KELLY INMAN
• 金额: $ 12.57万
• 依托单位: INTEGRATED LABORATORY SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2013-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535332
• 关键词: Animal Model; Autoimmune Process; Autoimmunity; Defect; Environmental Exposure; Fibrosis; Lung; Mus; Pathway interactions; Role; Silicon Dioxide; Tissues; Toxic effect; cell type

To dissect the pathways associated with tissue-specific fibrosis and systemic autoimmunity, the impact of the known immunomodulatory agent silica will be evaluated in autoimmune-prone mice with a genetically introduced pro-fibrotic defect (with and without Smad7 in different cell types).

为了剖析与组织特异性纤维化和全身性自身免疫相关的途径，将在具有遗传引入的促纤维化缺陷（在不同细胞类型中具有和不具有Smad7）的自身免疫易感小鼠中评价已知免疫调节剂二氧化硅的影响。