TCDD Induced Developmental Effects

TCDD 诱发的发育效应

• 批准号: 8535330
• 负责人: KELLY INMAN
• 金额: $ 22.24万
• 依托单位: INTEGRATED LABORATORY SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2013-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535330
• 关键词: Address; Adult; Development; Estradiol; Exposure to; Female; Gene Expression Alteration; Lactation; Mus; Progesterone; Role; Tetrachlorodibenzodioxin; endometriosis; mature animal; response

The purpose of the study is to examine changes in gene expression and alteration in adult uterine responsiveness in response to developmental exposure to TCDD. The study will address the effects of developmental exposure of female mice to TCDD at GD15, lactation and/or 4 weeks, uterine responsiveness to estradiol and/or estradiol+progesterone treatment as adult animals.

该研究的目的是研究基因表达的变化和成人子宫反应性的改变，以响应发育暴露于TCDD。本研究将探讨雌性小鼠在GD 15、哺乳期和/或4周时发育暴露于TCDD的影响，以及成年动物子宫对雌二醇和/或雌二醇+孕酮治疗的反应性。