Rapid breath detection of colorectal cancer with a colorimetric sensor array

使用比色传感器阵列快速呼吸检测结直肠癌

• 批准号: 8383030
• 负责人: Ray Anthony Martino
• 金额: $ 13.8万
• 依托单位: ISENSE, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-26 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8383030
• 关键词: Air; Anus; Area; Benzene; Biological; Biological Markers; Breath Tests; Canis familiaris; Carbon Dioxide; Characteristics; Chemicals; Clinic; Clinical Trials; Colon Carcinoma; Colonic Neoplasms; Colorectal; Colorectal Cancer; Complex Mixtures; Contracts; Detection; Development; Devices; Diagnostic; Discrimination; Exhalation; Formaldehyde; Foundations; Gases; Gel; Goals; Head; Institutional Review Boards; Malignant neoplasm of lung; Medical; Metabolism; Phase; Pilot Projects; Preparation; Prevention; Protocols documentation; Reporting; Research; Sampling; Smell Perception; Specificity; Staging; Surface; System; Technology; Thoracic Oncology; Toluene; Work; abstracting; anticancer research; base; meetings; research clinical testing; sensor; small molecule; tool

DESCRIPTION (provided by applicant): Project Summary/Abstract Recently it has been reported that canines can detect the presence of colon cancer from the scent of exhaled breath, with 91% selectivity and 99% specificity (Sonoda, H. et al., Gut, 2011, 60, 814). The prospect of a device which can perform similarly opens the prospect of a rapid, non-invasive, accurate and inexpensive breath test for colon cancer. The iSense Medical Corp. (IMC) sensor operates analogously to biological olfaction in that a diverse array of cross- reactive chemical sensors is activated by the breath sample. Prior work has shown this sensor system, based on colorimetric indicators embedded in a nanoporous sol-gel matrix of very high surface area, to be capable of discrimination of complex mixtures (Suslick, B. et al., Anal. Chem. 2010, 82, 2067), and has recently been shown in clinical testing at the Cleveland Clinic Foundation (CCF) to detect the presence of lung cancer from exhaled breath, across stages, with accuracy of 85% (Mazzone, P. et al., J. Thoracic Oncology, in press). Under this contract we propose to customize the nanoporous indicator array to optimize its sensitivity to small molecule metabolites of active colon tumor, and in Phase 2 conduct a pilot study at CCF to quantify accuracy of detection of colon cancer from breath, by stage. PUBLIC HEALTH RELEVANCE: Project Narrative The proposed research effort will develop a rapid, inexpensive and non-invasive diagnostic test for the presence of colon cancer, as a prompt for subsequent colonoscopic examination. A further application of this technology would be a breath test to non-invasively and inexpensively monitor the efficacy of chemotherapy treatment.

描述（由申请人提供）：最近有报道称，项目摘要/摘要，犬类可以从呼气呼吸的气味中检测出结肠癌的存在，具有91％的选择性和99％的特异性（Sonoda，H。et al。，Gut，2011，60，60，60，814）。可以执行类似设备的前景对结肠癌进行快速，非侵入性，准确和廉价的呼气测试的前景。 Isense Medical Corp.（IMC）传感器类似于生物学嗅觉，因为呼吸样品会激活各种跨反应性化学传感器。 Prior work has shown this sensor system, based on colorimetric indicators embedded in a nanoporous sol-gel matrix of very high surface area, to be capable of discrimination of complex mixtures (Suslick, B. et al., Anal. Chem. 2010, 82, 2067), and has recently been shown in clinical testing at the Cleveland Clinic Foundation (CCF) to detect the presence of lung cancer from exhaled breath, across stages, with精度为85％（Mazzone，P。等人，J。胸部肿瘤学，印刷中）。根据该合同，我们建议自定义纳米方指标阵列，以优化其对活性结肠肿瘤的小分子代谢产物的敏感性，并在第2阶段进行CCF进行试点研究，以量化逐步量化呼吸癌检测的准确性。 公共卫生相关性：项目叙述拟议的研究工作将对结肠癌的存在进行快速，廉价和无创的诊断测试，以促使随后的结肠镜检查。该技术的进一步应用将是一种呼吸测试，以非侵入性和廉价地监测化学疗法治疗的功效。