Rapid Identification of Pathogenic Bacteria and Sepsis Diagnosis
病原菌快速鉴定及脓毒症诊断
基本信息
- 批准号:8522889
- 负责人:
- 金额:$ 99.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-03-15 至 2015-02-28
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAccountingAddressAmericanAntibiotic TherapyAntibiotic susceptibilityAntibioticsBloodBlood VolumeCause of DeathClinicClinicalCollectionCulture MediaDetectionDevice or Instrument DevelopmentDiagnosisDocumentationDrug FormulationsGoalsGrantGrowthHourHumanInfectionIntensive Care UnitsLaboratoriesLibrariesMalignant neoplasm of lungMalignant neoplasm of prostateMeasuresMethodsNational Institute of Allergy and Infectious DiseaseOrganismPatientsPerformancePhasePredispositionProcessResearchSensitivity and SpecificitySepsisSiteSmall Business Innovation Research GrantSpecimenSpeedSystemSystems DevelopmentTechnologyTestingTimeUnited StatesVariantblindcommercializationcostcost effectiveeffective therapyinstrumentkillingsmalignant breast neoplasmmicroorganismpathogenic bacteriaprospectivepublic health relevancesoftware systems
项目摘要
DESCRIPTION (provided by applicant): Sepsis is the tenth-leading cause of death in the United States and the second-leading cause of death in the intensive care unit (ICU). Sepsis kills over 215,000 Americans each year - more than breast cancer, lung cancer, and prostate cancer combined. Rapid identification and determination of antibiotic susceptibility is critical fo effective treatment of infected patients. Phase I successfully demonstrated the iSense system's ability to discriminate bacterial species and strain 4-fold faster than legacy methods identify species alone. In Phase I iSense also successfully demonstrated the ability to determine strain-specific susceptibility to antibiotic therapy more than 1 day faster than conventional practice. Phase II aims address application to clinical human specimens along with development of instruments and media appropriate for commercial use. The ultimate goal of this research is to develop and commercially deploy an automated blood culture system that can diagnose sepsis, identify the species and strain of the infecting organism, and determine antibiotic susceptibility all in less than 24 hours from the lab's receipt of primary specimen.
描述(由申请人提供):脓毒症是美国第十大死亡原因,也是重症监护室(ICU)的第二大死亡原因。败血症每年导致超过215,000名美国人死亡-超过乳腺癌,肺癌和前列腺癌的总和。抗生素敏感性的快速鉴定和测定是有效治疗感染患者的关键。第一阶段成功地证明了iSense系统区分细菌种类和菌株的能力比传统方法单独识别种类快4倍。在I期试验中,iSense还成功证明了确定菌株对抗生素治疗的特异性敏感性的能力,比传统实践快1天以上。第II阶段的目标是解决临床人体标本的应用沿着适合商业用途的仪器和培养基的开发。这项研究的最终目标是开发和商业化部署一种自动血液培养系统,该系统可以诊断败血症,识别感染微生物的物种和菌株,并确定抗生素敏感性,所有这些都在实验室收到原始标本后不到24小时内完成。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ray Anthony Martino其他文献
Ray Anthony Martino的其他文献
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- 批准号:
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- 资助金额:
$ 99.49万 - 项目类别:
Rapid Identification of Pathogenic Bacteria in Blood causing Sepsis
快速鉴定血液中引起败血症的病原菌
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9335244 - 财政年份:2012
- 资助金额:
$ 99.49万 - 项目类别:
Rapid Identification of Pathogenic Bacteria and Sepsis Diagnosis
病原菌快速鉴定及脓毒症诊断
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8252659 - 财政年份:2012
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$ 99.49万 - 项目类别:
Rapid Identification of Pathogenic Bacteria and Sepsis Diagnosis
病原菌快速鉴定及脓毒症诊断
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8619581 - 财政年份:2012
- 资助金额:
$ 99.49万 - 项目类别:
Rapid Identification of Pathogenic Bacteria in Blood causing Sepsis
快速鉴定血液中引起败血症的病原菌
- 批准号:
9141453 - 财政年份:2012
- 资助金额:
$ 99.49万 - 项目类别:
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