Transcriptional Regulation During Cell Growth; Differentiation and Development

细胞生长过程中的转录调控；

• 批准号: 8319802
• 负责人: Susan E Mango
• 金额: $ 1.9万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-06 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319802
• 关键词: American; Area; Cancer Biology; Cells; Chromatin; Cities; Collaborations; Colorado; Communities; Complement; Congenital Abnormality; Development; Developmental Biology; Developmental Process; Diagnosis; Disabled Persons; Disease; Environment; Event; Faculty; Fostering; Functional RNA; Funding; Future; Gene Activation; Gene Expression Regulation; Genetic Transcription; Goals; Individual; Lead; Link; Malignant Neoplasms; Minority; Molecular; Nuclear; Participant; Pattern; Postdoctoral Fellow; Process; Recruitment Activity; Regulation; Research; Research Personnel; Scientist; Signal Transduction; Site; Skiing; Students; System; Time; Transcription Process; Transcriptional Regulation; Untranslated RNA; Woman; abstracting; cell fate specification; cell growth; chromatin remodeling; complex biological systems; disability; distraction; gene repression; human disease; interest; meetings; member; pluripotency; posters; programs; prospective; scientific organization; symposium; transcription factor

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference "Transcriptional Regulation during Cell Growth, Differentiation, and Development" to be held July 15 - 20, 2012 in Snowmass, Colorado. This conference represents a continuation of the highly successful biennial meeting that was first held in 1990. The goal of this meeting is to bring together scientists interested in the molecular underpinnings of transcription and chromatin regulation, in the context of organismal development. Currently, there are outstanding conferences on transcription and independently also on developmental biology, but there is relatively little overlap between the two, and most scientists in the two fieds attend separate meetings. The conference format will consist of nine morning and evening sessions of short talks followed by discussion and, in the afternoon, informal interactions and four poster sessions. The nine presentation sessions will cover classic topics as well as emerging areas in transcriptional control of development: pluripotency, transcription factor selectivity and cell fate specification, non-coding RNAs for transcriptional control, trans-generational signaling, nuclear organization, interpretation of gradients, small noncoding RNAs and transcriptional silencing, stochasticity and robustness. By maximizing both formal discussion and informal interactions, the FASEB conference on Transcriptional Regulation during Cell Growth, Differentiation, and Development will help to define both the present state and the future of the field. Prospective speakers were invited last spring, and almost all responded positively and with enthusiasm. The meeting will feature both established investigators and junior faculty with exciting new research programs. In an effort to appeal to the broader community and to maintain a lively environment, we have recruited many speakers who did not present in 2008 or 2010. By this criterion, 66% of our speakers are new to the meeting. The conference has three additional features that make it unique. 1) It intentionally spans a wide variety of experimental systems and focuses on areas of exceptional activity or promise. This leads to fruitful analyses and raises new questions about underlying mechanisms. Investigators have the opportunity to discuss the complete picture of how transcription and signaling networks are integrated to guide cell fate in normal vs. diseased states. 2) We have organized a program of 38 outstanding investigators who study transcription, development and cancer biology. They represent not only some of the most productive and creative members in the field, but also individuals with the capacity to generate fruitful discussions. We will invite 16 more speakers from the submitted abstracts, to highlight upcoming junior investigators. We anticipate a lively conference of 100-150 attendees. 3) The 2012 meeting will be held in Snowmass, Colorado, a geographically isolated site that keeps participants in close proximity for five days of in-depth discussion. PUBLIC HEALTH RELEVANCE: Funding is requested for partial support of a 5 day FASEB Summer Research Conference on "Transcriptional Regulation during Cell Growth, Differentiation, and Development", which will be held in Snowmass, Colorado July 15-20, 2012. Many human diseases and disorders, including cancer and congenital birth defects, are related to defective developmental events that are controlled in large part by altered patterns of gene transcription. Despite great progress in understanding how chromatin remodeling, gene transcription, and specific developmental processes are linked, there is no other meeting dedicated to bringing these two fields together. The purpose of this FASEB conference is to bring together outstanding researchers in the areas of transcriptional control and developmental biology for information exchange, thereby fostering collaboration and more rapid progress towards fundamental problems. The conference has three features that make it unique. 1) It intentionally spans a wide variety of experimental systems and focuses on areas of exceptional activity or promise. This leads to fruitful analyses and raises new questions about underlying mechanisms. Investigators have the opportunity to discuss the complete picture of how transcription and signaling networks are integrated to guide cell fate in normal vs. diseased states. 2) We have organized a program of 38 terrific investigators who study transcription, development and cancer biology. Our speakers include both leaders in the field as well as new investigators just establishing their own research programs. They will highlight diverse and cutting edge approaches to advancing our understanding of the regulation of gene networks during cell growth, differentiation, and development. We anticipate a lively conference of 100 to 150 attendees. 3) The 2012 meeting will be held in Snowmass, Colorado, a geographically isolated site that keeps participants in close proximity for five days of in-depth discussion.

描述（由申请人提供）：本申请为将于 2012 年 7 月 15 日至 20 日在科罗拉多州斯诺马斯举行的 FASEB 夏季会议“细胞生长、分化和发育期间的转录调控”寻求部分资助。本次会议是 1990 年首次举办的两年一次的会议的延续，该会议非常成功。本次会议的目标是将对生物体发育背景下转录和染色质调控的分子基础感兴趣的科学家聚集在一起。目前，转录方面有一些出色的会议，发育生物学方面也有独立的会议，但两者之间的重叠相对较少，两个领域的大多数科学家参加单独的会议。会议形式将包括九场上午和晚上的简短演讲，随后进行讨论，下午进行非正式互动和四场海报会议。九场演讲会议将涵盖发育转录控制的经典主题和新兴领域：多能性、转录因子选择性和细胞命运规范、用于转录控制的非编码RNA、跨代信号、核组织、梯度解释、小非编码RNA和转录沉默、随机性和鲁棒性。通过最大化正式讨论和非正式互动，FASEB 关于细胞生长、分化和发育过程中转录调控的会议将有助于定义该领域的现状和未来。去年春天邀请了潜在的演讲者，几乎所有人都做出了积极而热情的回应。会议将邀请知名研究人员和初级教师参加令人兴奋的新研究项目。为了努力呼吁 为了扩大社区范围并保持活跃的环境，我们招募了许多 2008 年或 2010 年没有出席的演讲者。按照这个标准，66% 的演讲者是会议的新人。此次会议还具有三个独特的特点。 1）它有意涵盖各种实验系统，并重点关注具有特殊活动或前景的领域。这带来了富有成效的分析，并提出了有关潜在机制的新问题。研究人员有机会全面讨论转录和信号网络如何整合以指导正常状态与患病状态下的细胞命运。 2) 我们组织了一个由 38 名研究转录、发育和癌症生物学的杰出研究人员组成的项目。他们不仅代表了该领域一些最具生产力和创造力的成员，而且还代表了有能力进行富有成效的讨论的个人。我们将从提交的摘要中再邀请 16 位演讲者，以突出即将到来的初级研究人员。我们预计会议将有 100-150 人参加，热闹非凡。 3) 2012年的会议将在科罗拉多州斯诺马斯举行，这是一个地理位置偏僻的地点，但与会者可以近距离进行为期五天的深入讨论。 公共健康相关性：请求资助为期 5 天的 FASEB 夏季研究会议，主题为“细胞生长、分化和发育过程中的转录调控”，该会议将于 2012 年 7 月 15 日至 20 日在科罗拉多州斯诺马斯举行。许多人类疾病和失调，包括癌症和先天性出生缺陷，都与发育缺陷事件有关，这些发育事件在很大程度上是由基因转录模式改变控制的。尽管在理解染色质重塑、基因转录和特定发育过程之间的联系方面取得了巨大进展，但还没有其他会议致力于将这两个领域结合在一起。此次FASEB会议的目的是汇集转录控制和发育生物学领域的杰出研究人员进行信息交流，从而促进合作并在解决基本问题上取得更快的进展。本次会议具有三个独特的特点。 1）它有意涵盖各种实验系统，并重点关注具有特殊活动或前景的领域。这带来了富有成效的分析，并提出了有关潜在机制的新问题。研究人员有机会全面讨论转录和信号网络如何整合以指导正常状态与患病状态下的细胞命运。 2) 我们组织了一个由 38 名出色的研究人员组成的项目，他们研究转录、发育和癌症生物学。我们的演讲者包括该领域的领导者以及刚刚建立自己的研究项目的新研究人员。他们将重点介绍多种前沿方法，以增进我们对细胞生长、分化和发育过程中基因网络调控的理解。我们预计会议将有 100 至 150 人参加，热闹非凡。 3) 2012年的会议将在科罗拉多州斯诺马斯举行，这是一个地理位置偏僻的地点，但与会者可以近距离进行为期五天的深入讨论。