2012 Single-Molecule Approaches to Biology Gordon Research Conference

描述（由申请人提供）：我们请求部分支持戈登研究会议的“单分子生物学方法”将在佛蒙特州的山雪度假村，2012年7月15日至20日举行。单分子技术在各级生物学研究中迅速占据中心地位。使用荧光和力探针在体外以及活细胞中一次追踪一个分子构象的稳健技术的发展提供了以前无法获得的关于所有生命形式所必需的基本生化过程的数据。我们的会议旨在为生物学家，物理学家，化学家和工程师提供一个跨学科的论坛，他们已经开发出可以随时应用于解决重要生物学问题的单分子方法。我们寻求传播单分子技术的实施和使用，以追求新的生物学知识，并教育希望学习如何进行跨学科研究的年轻科学家。我们的目标是召集25位演讲者和10位讨论负责人，将该领域的杰出专家与生物学家结合起来，展示单分子技术在新系统中的应用。我们的目标是在为期五天的会议上共有170名与会者。该计划将以新兴的单分子应用为特色，以研究核糖体，蛋白酶体和细胞结合反应以及其他引人注目的生物系统。该计划还将以单分子物理学的模拟和新的理论发展为特色。开发单分子技术，如DNA窗帘和超分辨率成像也将成为特色。此外，两个海报会议将为与会者提供各种机会，积极参与科学讨论。海报 会议将持续两天，以便与会者充分讨论他们的工作。这一应用的健康相关性源于这样一个事实，即单分子研究产生的关于分子动力学的丰富新知识有望在以前不可能的水平上揭示各种疾病的分子起源。 公共卫生相关性：这一应用的健康相关性源于这样一个事实，即单分子研究产生的关于分子动力学的丰富新知识有望在以前不可能的水平上揭示各种疾病的分子起源。

DESCRIPTION (provided by applicant): We request partial support for the Gordon Research Conference on "Single-Molecule Approaches to Biology" to be held at the Mt Snow Resort in Vermont, July 15 - 20, 2012. Single molecule techniques are rapidly occupying a central role in biological research at all levels. The development of robust techniques that use fluorescence and force probes to track the conformation of molecules one at a time, both in vitro as well as in live cells, provides previously unobtainable data on fundamental biochemical processes that are essential for all forms of life. Our conference aims to provide an interdisciplinary forum for biologists, physicists, chemists and engineers who have developed single molecule methodologies that can be readily applied to solve important biological problems. We seek to disseminate the implementation and use of single molecule techniques in the pursuit of new biological knowledge and educate young scientists that wish to learn how to conduct interdisciplinary research. We aim to convene 25 speakers and 10 discussion leaders combining prominent experts in the field together with biologists that demonstrate the use of single molecule techniques in new systems. We aim for a total of 170 participants for the five day conference. The program will feature emerging new single molecule applications to study the ribosome, the proteasome, and cell binding reactions, amongst other compelling biological systems. The program will also feature simulations and new theoretical developments on the physics of single molecules. Developing single molecule techniques such as DNA curtains and super resolution imaging will be featured as well. In addition, two poster sessions will give participants various opportunities to actively participate in the scientific discourse. The posters will remain in place for two days, to allow participants for ample discussion of their work. The health-relatedness of this application derives from the fact that the rich new knowledge on the dynamics of molecules that results from single molecule studies promises to uncover the molecular origins of a wide range of diseases at a level that was not previously possible. PUBLIC HEALTH RELEVANCE: The health-relatedness of this application derives from the fact that the rich new knowledge on the dynamics of molecules that results from single molecule studies promises to uncover the molecular origins of a wide range of diseases at a level that was not previously possible.