2012 Single-Molecule Approaches to Biology Gordon Research Conference

描述（由申请人提供）：我们要求部分支持将于2012年7月15日至20日在佛蒙特州雪山度假村举行的戈登“单分子生物学方法”研究会议。单分子技术正迅速地在各个层面的生物学研究中占据中心地位。利用荧光和力探针在体外和活细胞中一次一个地追踪分子构象的强大技术的发展，提供了以前无法获得的关于所有生命形式所必需的基本生化过程的数据。我们的会议旨在为生物学家、物理学家、化学家和工程师提供一个跨学科的论坛，他们已经开发了单分子方法，可以很容易地应用于解决重要的生物学问题。我们寻求传播单分子技术的实施和使用，以追求新的生物学知识，并教育希望学习如何进行跨学科研究的年轻科学家。我们的目标是召集25位演讲者和10位讨论领袖，将该领域的知名专家与生物学家结合起来，展示单分子技术在新系统中的应用。我们的目标是总共有170人参加为期五天的会议。该计划将以新兴的单分子应用为特色，研究核糖体、蛋白酶体和细胞结合反应，以及其他引人注目的生物系统。该计划还将以单分子物理学的模拟和新理论发展为特色。发展单分子技术，如DNA帷幕和超分辨率成像也将成为特色。此外，两场海报会议将为与会者提供各种积极参与科学话语的机会。海报

DESCRIPTION (provided by applicant): We request partial support for the Gordon Research Conference on "Single-Molecule Approaches to Biology" to be held at the Mt Snow Resort in Vermont, July 15 - 20, 2012. Single molecule techniques are rapidly occupying a central role in biological research at all levels. The development of robust techniques that use fluorescence and force probes to track the conformation of molecules one at a time, both in vitro as well as in live cells, provides previously unobtainable data on fundamental biochemical processes that are essential for all forms of life. Our conference aims to provide an interdisciplinary forum for biologists, physicists, chemists and engineers who have developed single molecule methodologies that can be readily applied to solve important biological problems. We seek to disseminate the implementation and use of single molecule techniques in the pursuit of new biological knowledge and educate young scientists that wish to learn how to conduct interdisciplinary research. We aim to convene 25 speakers and 10 discussion leaders combining prominent experts in the field together with biologists that demonstrate the use of single molecule techniques in new systems. We aim for a total of 170 participants for the five day conference. The program will feature emerging new single molecule applications to study the ribosome, the proteasome, and cell binding reactions, amongst other compelling biological systems. The program will also feature simulations and new theoretical developments on the physics of single molecules. Developing single molecule techniques such as DNA curtains and super resolution imaging will be featured as well. In addition, two poster sessions will give participants various opportunities to actively participate in the scientific discourse. The posters will remain in place for two days, to allow participants for ample discussion of their work. The health-relatedness of this application derives from the fact that the rich new knowledge on the dynamics of molecules that results from single molecule studies promises to uncover the molecular origins of a wide range of diseases at a level that was not previously possible. PUBLIC HEALTH RELEVANCE: The health-relatedness of this application derives from the fact that the rich new knowledge on the dynamics of molecules that results from single molecule studies promises to uncover the molecular origins of a wide range of diseases at a level that was not previously possible.