2012 Single-Molecule Approaches to Biology Gordon Research Conference

描述(由申请者提供)：我们请求部分支持将于2012年7月15-20日在佛蒙特州雪山度假村举行的戈登研究会议“单分子生物学方法”。单分子技术正迅速在各个层面的生物学研究中占据中心地位。在体外和活细胞中，使用荧光和力探针一次追踪一个分子的构象的强大技术的发展，提供了以前无法获得的关于所有形式的生命所必需的基本生化过程的数据。我们的会议旨在为生物学家、物理学家、化学家和工程师提供一个跨学科的论坛，他们已经开发出可以很容易地应用于解决重要生物学问题的单分子方法。我们寻求在追求新的生物学知识的过程中传播单分子技术的实施和使用，并教育希望学习如何进行跨学科研究的年轻科学家。我们的目标是召集25名演讲者和10名讨论负责人，将该领域的知名专家与生物学家结合在一起，展示单分子技术在新系统中的使用。我们的目标是在五天的会议上总共有170人参加。该计划将以新兴的单分子应用为特色，研究核糖体、蛋白酶体和细胞结合反应，以及其他引人注目的生物系统。该计划还将以单分子物理学的模拟和新的理论发展为特色。开发单分子技术，如DNA窗帘和超分辨率成像也将是特色。此外，两个海报会议将为与会者提供各种机会，积极参与科学话语。海报 将保留两天，以便与会者充分讨论他们的工作。这项应用与健康的相关性源于这样一个事实，即单分子研究产生的丰富的分子动力学新知识有望在以前不可能的水平上揭示一系列疾病的分子起源。 公共卫生相关性：这项应用与健康的相关性源于这样一个事实，即单分子研究产生的丰富的分子动力学新知识有望在以前不可能的水平上揭示一系列疾病的分子起源。

DESCRIPTION (provided by applicant): We request partial support for the Gordon Research Conference on "Single-Molecule Approaches to Biology" to be held at the Mt Snow Resort in Vermont, July 15 - 20, 2012. Single molecule techniques are rapidly occupying a central role in biological research at all levels. The development of robust techniques that use fluorescence and force probes to track the conformation of molecules one at a time, both in vitro as well as in live cells, provides previously unobtainable data on fundamental biochemical processes that are essential for all forms of life. Our conference aims to provide an interdisciplinary forum for biologists, physicists, chemists and engineers who have developed single molecule methodologies that can be readily applied to solve important biological problems. We seek to disseminate the implementation and use of single molecule techniques in the pursuit of new biological knowledge and educate young scientists that wish to learn how to conduct interdisciplinary research. We aim to convene 25 speakers and 10 discussion leaders combining prominent experts in the field together with biologists that demonstrate the use of single molecule techniques in new systems. We aim for a total of 170 participants for the five day conference. The program will feature emerging new single molecule applications to study the ribosome, the proteasome, and cell binding reactions, amongst other compelling biological systems. The program will also feature simulations and new theoretical developments on the physics of single molecules. Developing single molecule techniques such as DNA curtains and super resolution imaging will be featured as well. In addition, two poster sessions will give participants various opportunities to actively participate in the scientific discourse. The posters will remain in place for two days, to allow participants for ample discussion of their work. The health-relatedness of this application derives from the fact that the rich new knowledge on the dynamics of molecules that results from single molecule studies promises to uncover the molecular origins of a wide range of diseases at a level that was not previously possible. PUBLIC HEALTH RELEVANCE: The health-relatedness of this application derives from the fact that the rich new knowledge on the dynamics of molecules that results from single molecule studies promises to uncover the molecular origins of a wide range of diseases at a level that was not previously possible.