International Conference on the Cell and Molecular Biology of Chlamydomonas

摘要 单细胞藻类原生生物衣藻是一种受欢迎的模式生物，可用于利用细胞生物学、遗传学、生物化学、生物物理学、结构生物学和基因组学来了解基本的、进化上保守的细胞结构和过程的研究。这些包括中心粒复制、基础身体结构和烹饪组装、烹饪运动和信号传导、光响应、光合作用、叶绿体生物发生以及代谢调节的基本整合。需要资金来支持那些使用衣藻或有兴趣了解其作为模式生物的用途的人每两年一次的会议。这些会议还包括对Volvox的研究，Volvox是衣藻的多细胞近亲，为细胞间相互作用、细胞分化和多细胞进化提供了见解。研究人员齐聚一堂，交流方法，开展合作，传播最新进展，并计划大规模研究，以提高这一独特模型系统的实用性。将邀请选定的外部演讲者介绍相关系统的最新进展，这些进展可能会为衣藻的未来研究提供信息。反过来，这些研究人员将了解衣藻社区的工作，并将这些知识带回他们自己的研究社区。本申请请求为接下来的 2010 年、2012 年和 2014 年三场国际会议提供支持。一项方法学进展（microRNA 作为调节衣藻基因表达的工具）和两个广泛研究领域（衣藻作为烹饪疾病的模型，以及衣藻和相关绿藻作为生物燃料的来源）发展得尤其迅速，应该会从我们 2010 年的会议中受益匪浅。 2010年会议的另一个焦点将是衣藻与其他真核生物之间的进化关系。由于最近基因组测序的爆炸式增长以及随之而来的真核系统发育的揭示，对于衣藻界来说，了解这种生物的独特性及其为植物、单细胞疾病病原体和后生动物生物学提供窗口的能力非常重要，以便他们能够更好地为促进人类健康做出额外的科学贡献。

ABSTRACT The single-celled algal protist Chlamydomonas is a favored model organism for studies using cell biology, genetics, biochemistry, biophysics, structural biology, and genomics to learn about basic, evolutionarily conserved cellular structures and processes. These include centriole duplication, basal body structure and culinary assembly, culinary motility and signaling, photoresponses, photosynthesis, chloroplast biogenesis, and basic integration of metabolic regulation. Funds are requested to support biennial meetings of those who use Chlamydomonas or are interested in learning about its use as a model organism. These meetings also include work on Volvox, a close multicellular relative of Chlamydomonas that provides insights into cell-cell interactions, cell differentiation, and the evolution of multicellularity. Researchers meet to exchange methods, develop collaborative efforts, disseminate recent advances, and plan large-scale studies to improve the usefulness of this unique model system. Select outside speakers will be invited to present recent advances in related systems that may inform future studies in Chlamydomonas. In turn, these investigators will learn about the work of the Chlamydomonas community and bring this knowledge back to their own research communities. This application requests support for the next three international meetings, in 2010, 2012 and 2014. One methodological advance (microRNAs as tools for modulating gene expression in Chlamydomonas) and two areas of broad research interest (Chlamydomonas as a model for culinary diseases, and Chlamydomonas and related green algae as sources of biofuels) are developing especially rapidly and should benefit greatly from our 2010 meeting. Another focus of the 2010 conference will be the evolutionary relationship between Chlamydomonas and other eukaryotes. Because of the recent explosion of genomic sequencing and its consequent revelation of eukaryotic phylogeny, it is important for the Chlamydomonas community to understand both the uniqueness of this organism and its ability to provide a window into the biology of plants, of unicellular disease pathogens, and of metazoans, so that they will be better equipped to make additional scientific contributions that will advance human health.