International Conference on the Cell and Molecular Biology of Chlamydomonas

衣藻细胞和分子生物学国际会议

• 批准号: 7916011
• 负责人: DAVID R MITCHELL
• 金额: $ 0.5万
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916011
• 关键词: Animal Model; Area; Back; Biochemistry; Biogenesis; Biological Models; Biology; Biophysics; Cell Communication; Cell Cycle; Cell Differentiation process; Cells; Cellular Structures; Cellular biology; Centrioles; Chlamydomonas; Chloroplasts; Communities; Defect; Disease; Eukaryota; Evolution; Explosion; Funding; Future; Gene Expression; Genetic; Genomics; Green Algae; Health; Human; International; Knowledge; Learning; Metabolic; Methods; MicroRNAs; Mitochondria; Modeling; Molecular Biology; Organism; Photosynthesis; Phylogeny; Plants; Process; Regulation; Relative (related person); Request for Applications; Research; Research Personnel; Signal Transduction; Source; Structure; System; Volvox; Work; cell motility; improved; insight; interest; kinetosome; meetings; pathogen; public health relevance; structural biology; symposium; tool

DESCRIPTION (provided by applicant): The single-celled algal protist Chlamydomonas is a favored model organism for studies using cell biology, genetics, biochemistry, biophysics, structural biology, and genomics to learn about basic, evolutionarily conserved cellular structures and processes. These include centriole duplication, basal body structure and culinary assembly, culinary motility and signaling, photoresponses, photosynthesis, chloroplast biogenesis, and basic integration of metabolic regulation. Funds are requested to support biennial meetings of those who use Chlamydomonas or are interested in learning about its use as a model organism. These meetings also include work on Volvox, a close multicellular relative of Chlamydomonas that provides insights into cell-cell interactions, cell differentiation, and the evolution of multicellularity. Researchers meet to exchange methods, develop collaborative efforts, disseminate recent advances, and plan large-scale studies to improve the usefulness of this unique model system. Select outside speakers will be invited to present recent advances in related systems that may inform future studies in Chlamydomonas. In turn, these investigators will learn about the work of the Chlamydomonas community and bring this knowledge back to their own research communities. This application requests support for the next three international meetings, in 2010, 2012 and 2014. One methodological advance (microRNAs as tools for modulating gene expression in Chlamydomonas) and two areas of broad research interest (Chlamydomonas as a model for culinary diseases, and Chlamydomonas and related green algae as sources of biofuels) are developing especially rapidly and should benefit greatly from our 2010 meeting. Another focus of the 2010 conference will be the evolutionary relationship between Chlamydomonas and other eukaryotes. Because of the recent explosion of genomic sequencing and its consequent revelation of eukaryotic phylogeny, it is important for the Chlamydomonas community to understand both the uniqueness of this organism and its ability to provide a window into the biology of plants, of unicellular disease pathogens, and of metazoans, so that they will be better equipped to make additional scientific contributions that will advance human health. PUBLIC HEALTH RELEVANCE: Funds will support three biennial meetings of the International Conference on the Cell and Molecular Biology of Chlamydomonas. Researchers will exchange information that improves their ability to use this simple organism to investigate the basic causes of ciliopathies, mitochondrial defects, cell cycle defects, and other cellular phenomena best studied in this unique model system.

描述（由申请人提供）：单细胞藻类原生生物衣原体是使用细胞生物学、遗传学、生物化学、生物物理学、结构生物学和基因组学进行研究以了解基本的、进化上保守的细胞结构和过程的优选模式生物。这些包括中心粒复制，基体结构和烹饪组装，烹饪运动和信号，光反应，光合作用，叶绿体生物发生和代谢调节的基本整合。要求提供资金，以支助使用衣原体或有兴趣了解如何将衣原体用作模式生物的人举行两年期会议。这些会议还包括团藻的工作，团藻是衣原体的一种密切的多细胞亲戚，它提供了对细胞间相互作用，细胞分化和多细胞进化的见解。研究人员会面交流方法，发展合作努力，传播最新进展，并计划大规模研究，以提高这个独特的模型系统的有用性。选择外部扬声器将被邀请到目前在相关系统的最新进展，可能会通知衣原体未来的研究。反过来，这些研究人员将了解衣原体社区的工作，并将这些知识带回自己的研究社区。该申请请求为2010年、2012年和2014年的下三次国际会议提供支持。一个方法上的进步（microRNAs作为调控衣原体基因表达的工具）和两个广泛的研究领域（衣原体作为烹饪疾病的模型，以及衣原体和相关的绿色藻类作为生物燃料的来源）正在特别迅速地发展，应该从我们2010年的会议中受益匪浅。2010年会议的另一个焦点将是衣原体和其他真核生物之间的进化关系。由于最近的爆炸式增长的基因组测序和其随之而来的真核生物发生学的启示，这是重要的衣原体社区了解这种生物的独特性和它的能力，提供一个窗口到植物的生物学，单细胞疾病病原体，和后生动物，使他们将更好地装备，使更多的科学贡献，将促进人类健康。 公共卫生相关性：资金将用于支持衣原体细胞和分子生物学国际会议的三次两年期会议。研究人员将交换信息，提高他们使用这种简单生物体的能力，以研究纤毛病，线粒体缺陷，细胞周期缺陷和其他细胞现象的基本原因，这些现象在这个独特的模型系统中得到了最好的研究。