7th Biennial Symposium on Polyamines in Parasites

第七届寄生虫多胺双年研讨会

• 批准号: 8319079
• 负责人: Sigrid Christiane Roberts
• 金额: $ 0.6万
• 依托单位: PACIFIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319079
• 关键词: Antiparasitic Agents; Area; Biochemical; Biochemistry; Collaborations; Communication; Developing Countries; Development; Disease; Drug Delivery Systems; Drug resistance; Enzymes; Fostering; Funding; Genetic; Germany; Goals; Human; International; Laboratories; Metabolic; Metabolic Pathway; Minority; Molecular Biology; Morbidity - disease rate; Nature; New York; Oregon; Organism; Parasites; Parasitic Diseases; Participant; Pathway interactions; Pharmaceutical Preparations; Polyamines; Postdoctoral Fellow; Principal Investigator; Protozoa; Research; Research Personnel; Series; South Africa; Students; Synthesis Chemistry; Travel; United States; Universities; Vaccines; Validation; Work; design; drug discovery; forest; graduate student; inhibitor/antagonist; interest; meetings; mortality; new therapeutic target; novel therapeutics; pathogen; posters; resistance mechanism; structural biology; symposium; undergraduate student

DESCRIPTION (provided by applicant): The 7th Biennial Symposium on Polyamines in Parasites will be held at Pacific University, Forest Grove, Oregon, on July 10-13, 2012. The focus of the meeting will be the polyamine pathway as a drug target in parasitic protozoa and other pathogens. Disease-causing parasitic organisms contain polyamine metabolic enzymes that are structurally distinct from their human counterparts, or that do not exist in humans, and thus these enzymes represent attractive targets for antiparasitic drug discovery. The symposium will be interdisciplinary in nature; thus far, participants with expertise in molecular biology, biochemistry, genetics, synthetic chemistry, and structural biology have expressed interest in attending. The meeting will be composed of a series of 30 min talks given by meeting participants and will include a poster session for students and postdoctoral fellows to present their work. A keynote presentation and a round table discussion are also planned. Topics will include: polyamine metabolic pathways in protozoan parasites and other pathogens, validation of polyamine enzyme drug targets, biochemical and structural characterization of polyamine enzymes, drug discovery and inhibitor design, and drug resistance mechanisms. The goal of the symposium is to assess the most recent state of research in the area of polyamines in parasites, develop new scientific collaborations and coordinate drug discovery efforts, with the aim of identifying effective drug treatments for uncontrolled parasitic diseases. Participants will include principal investigators, postdoctoral fellows, and students from both United States and international laboratories that are working directly in the area of the meeting, as well as local Oregon students at the graduate and undergraduate level. The symposium was initiated in Hamburg, Germany, in 2000, and has been held biennially in San Antonia, TX, (2002); New York, NY, (2004); Portland, OR, (2006); Detroit, MI (2008); and Phalaborwa, South Africa (2010). PUBLIC HEALTH RELEVANCE: The 7th Biennial Symposium on Polyamines in Parasites, to be held at Pacific University in the summer of 2012, is a meeting focused on the polyamine pathway as a potential drug target. Parasites cause severe morbidity and mortality predominantly in developing countries and the need for new therapeutic strategies is urgent. The goal of the meeting is to discuss recent scientific developments and to foster communication, networking, and collaborations.

描述（由申请人提供）：第七届两年一度的寄生虫多胺研讨会将于2012年7月10日至13日在俄勒冈州森林格罗夫太平洋大学举行。会议的重点将是多胺途径作为寄生原生动物和其他病原体的药物靶点。致病寄生生物体含有多胺代谢酶，其在结构上不同于其人类对应物，或不存在于人类中，因此这些酶代表抗寄生虫药物发现的有吸引力的靶标。研讨会将是跨学科的性质;到目前为止，具有分子生物学，生物化学，遗传学，合成化学和结构生物学专业知识的参与者表示有兴趣参加。会议将由与会者提供的一系列30分钟的演讲组成，并将包括学生和博士后研究员展示他们工作的海报会议。还计划进行主题演讲和圆桌讨论。主题将包括：原生动物寄生虫和其他病原体中的多胺代谢途径，多胺酶药物靶标的验证，多胺酶的生物化学和结构表征，药物发现和抑制剂设计，以及耐药性机制。研讨会的目标是评估寄生虫中多胺领域的最新研究状况，发展新的科学合作并协调药物发现工作，目的是确定治疗不受控制的寄生虫病的有效药物。参与者将 包括主要研究人员、博士后研究员、来自美国和国际实验室的直接在会议区域工作的学生，以及俄勒冈州当地的研究生和本科生。该专题讨论会于2000年在德国汉堡发起，每两年在德克萨斯州圣安东尼奥（2002年）、纽约州纽约（2004年）、俄勒冈州波特兰（2006年）、密歇根州底特律（2008年）和南非帕拉博尔瓦（2010年）举行一次。 公共卫生关系：第七届寄生虫多胺双年度研讨会将于2012年夏天在太平洋大学举行，会议重点是多胺途径作为潜在的药物靶点。寄生虫主要在发展中国家造成严重的发病率和死亡率，迫切需要新的治疗策略。会议的目的是讨论最近的科学发展，促进沟通，网络和合作。