Biomolecule Production Core

生物分子生产核心（BPC）的总体目标是提供必要的 用于表达和纯化生物分子的基础设施，包括抗原，蛋白质， 来自BSL-3和BSL-4制剂的荚膜碳水化合物、核酸和其他生物制剂， 与NEIDL相关的研究人员。 此外，BPC将负责BSL-3的繁殖、纯化和储存， BSL-4 病原体核心还将为NEIDL研究人员提供BSL-4的灭活材料 可用于研究目的的病原体，包括用于抗体生产的抗原。 此外，该核心将提供筛选抗病毒化合物的基础设施， 微阵列分析和进行BSL-4细胞培养感染研究。最后，BPC将提供 对与NEIDL相关的个别研究人员进行核心特定技术培训， 核心设备自用。

The overall objective of the Biomolecule Production Core (BPC) is to provide the necessary infrastructure for the expression and purification of biologic molecules including antigens, proteins, capsular carbohydrates, nucleic acids and other biologics from BSL-3 and BSL-4 agents for investigators associated with the NEIDL. In addition, the BPC will be responsible for the propagation, purification and storage of BSL-3 and BSL-4 pathogens. The core will also provide NEIDL investigators with inactivated material from BSL-4 pathogens that can be used for research purposes, including antigens for antibody production. Furthermore, the core will provide the infrastructure for screening antiviral compounds, conducting microarray analyses, and performing BSL-4 cell culture infection studies. Finally, the BPC will offer training in core-specific techniques to individual researchers associated with the NEIDL enabling self-use of core equipment.