Biomolecule Production Core

生物分子生产核心

• 批准号: 8709527
• 负责人: Elke C Muhlberger
• 金额: $ 2.44万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8709527
• 关键词: Antibody Formation; Antigens; Antiviral Agents; Carbohydrates; Categories; Cell Culture Techniques; Collaborations; Containment; Emerging Communicable Diseases; Equipment; Human Resources; Individual; Infection; Infectious Diseases Research; Laboratories; Methods; Nucleic Acids; Procedures; Production; Proteins; Research; Research Activity; Research Infrastructure; Research Personnel; Simulate; System; Techniques; Testing; Time; Training; Training Programs; biosecurity; operation; pathogen; programs; screening

The overall objective of the Biomolecule Production Core (BPC) is to provide the necessary infrastructure for the expression and purification of biologic molecules including antigens, proteins, capsular carbohydrates, nucleic acids and other biologics from BSL-3 and BSL-4 agents for investigators associated with the NEIDL. In addition, the BPC will be responsible for the propagation, purification and storage of BSL-3 and BSL-4 pathogens. The core will also provide NEIDL investigators with inactivated material from BSL-4 pathogens that can be used for research purposes, including antigens for antibody production. Furthermore, the core will provide the infrastructure for screening antiviral compounds, conducting microarray analyses, and performing BSL-4 cell culture infection studies. Finally, the BPC will offer training in core-specific techniques to individual researchers associated with the NEIDL enabling self-use of core equipment.

生物分子生产核心(BPC)的总体目标是提供必要的 表达和纯化生物分子的基础设施，包括抗原、蛋白质、 来自BSL-3和BSL-4制剂的胶囊碳水化合物、核酸和其他生物制品 与Neidl有关联的调查人员。 此外，BPC将负责BSL-3和BSL-3的繁殖、提纯和储存 BSL-4 病原体。该核心还将向Neidl调查人员提供来自BSL-4的灭活材料 可用于研究目的的病原体，包括用于产生抗体的抗原。 此外，该核心将为筛选抗病毒化合物提供基础设施，进行 基因芯片分析，并进行BSL-4细胞培养感染研究。最后，BPC将提供 对与NEIDL支持相关的个人研究人员进行特定于核心的技术培训 核心设备自用。