ASBMR Topical Meeting on Bone and Skeletal Muscle Interactions

描述(申请人提供)：每年肌肉骨骼疾病的医疗保健费用高达数十亿美元。每年发生的所有伤害中有一半以上是肌肉骨骼系统的伤害，导致大量工作和上学时间的损失。儿童时期的肌肉骨骼疾病可能是毁灭性的，随着年龄的增长，石棺减少和骨质疏松症的负担继续增加。骨骼减少，肌肉萎缩，导致平衡不良，行走速度减慢，摔倒和骨折，可以被认为是肌肉相当于骨质疏松症。虽然众所周知，肌肉和骨骼对运动有反应，但我们对这两个组织之间的细胞和分子相互作用知之甚少。因此，我们提议召开一次会议，将国内和国际领先的肌肉和骨骼研究人员聚集在一起，交流思想，发展新的合作。这次会议将为在这一重要的肌肉和骨骼相互作用领域快速和开放地交流思想和研究成果创造一个场所。我们会议的直接目标是找出关键的 研究主题将导致肌肉和骨骼研究人员之间的合作赠款申请，随后在出版物和演示文稿等场所传播本次会议的结果。本次会议的具体目标包括：了解肌肉和骨骼在发育和生长过程中的密切联系，以及营养和体力活动如何影响一般健康，剖析衰老在 目的：确定骨骼肌减少与骨质疏松症之间的联系，确定导致肌肉和骨骼密切联系的分子和细胞机制，确定肌肉和骨骼中有缺陷的机械转导，确定肌肉与骨骼之间的联系是否独立于机械负荷，确定预防、治疗和逆转或再生肌肉和骨丢失的关节方法，以及评估建立一个整合肌肉和骨生理学的综合研究领域的可行性。最终目标是更好地理解这两个组织如何在健康和疾病中整合和相互干扰。我们的目标和希望是，这次会议将触发新的治疗战略，以加强和维持肌肉骨骼健康。 公共卫生相关性：在一生中，从童年到老年，骨骼和肌肉紧密相连。其中一个组织的疾病或损伤会影响另一个组织。尽管骨骼的肌肉负荷显然在这种相互作用中发挥了作用，但人们对潜在的细胞和分子机制知之甚少。因此，本次会议建议将领先的肌肉和骨骼研究人员聚集在一起，以确定将导致合作解决肌肉骨骼疾病的关键研究领域。

DESCRIPTION (provided by applicant): Annual health care costs for musculoskeletal disease are in the billions. More than half of all injuries occurring each year are to the musculoskeletal system resulting in significant loss of work and school days. Musculoskeletal disease in childhood can be devastating and the burden of sarcopenia and osteoporosis with age continues to increase. Sarcopenia, muscle wasting, results in poor balance, reduced walking speed, falls, and fractures and can be thought of as the muscular equivalent of osteoporosis. Although it is well recognized that muscle and bones are responsive to exercise, we know little regarding cellular and molecular interactions between these two tissues. Therefore, we are proposing a conference to draw together leading muscle and bone researchers nationally and internationally to exchange ideas and to develop new collaborations. This conference would create a venue for the rapid and open exchange of ideas and research results in this important field of muscle and bone interactions. The immediate goal of our conference is to identify critical research themes that would lead to collaborative grant applications between muscle and bone researchers followed by dissemination of findings from this meeting in venues such as publications and presentations. Specific aims to be addressed at this meeting include: to understand the close association between muscle and bone during development and growth and how nutrition and physical activity affects general health, to dissect the role of aging in the association between sarcopenia and osteoporosis, to identify molecular and cellular mechanisms responsible for the close association between muscle and bone, to define defective mechanotransduction in both muscle and bone, to determine if muscle communicates with bone independent of mechanical loading, to identify joint approaches to prevent, treat, and reverse or regenerate muscle and bone loss, and to assess the feasibility of establishing a combined research field that integrates both muscle and bone physiology. The ultimate goal is to generate a better understanding of how these two tissues integrate and crosstalk in both health and disease. The goal and hope is that this meeting will trigger new therapeutic strategies to enhance and maintain musculoskeletal health. PUBLIC HEALTH RELEVANCE: Throughout life, from childhood to old age, bone and muscle are tightly and intimately connected. Disease or injury in either tissue affects the other. Althoug muscle loading of bone clearly plays a role in this interaction, little is known about potential cellular and molecular mechanisms. Therefore this conference is proposed to bring together leading muscle and bone researchers to identify critical research areas that would lead to collaborations to address musculoskeletal disease.