Psychophysiology of Emotion in Parkinsons Disease

帕金森病情绪的心理生理学

• 批准号: 8214104
• 负责人: Jenna B Renfroe
• 金额: $ 3.46万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-16 至 2014-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8214104
• 关键词: Affect; Affective; Anhedonia; Anxiety; Arousal; Attention; Behavior; Blinking; Caregiver Burden; Chemosensitization; Cognitive; Complex; Conflict (Psychology); Cues; Defect; Disease; Dopamine; Elderly; Emotional; Emotional Disturbance; Emotions; Employee Strikes; Event-Related Potentials; Functional disorder; Goals; Guns; Impaired cognition; Individual; Learning; Light; Link; Measures; Mediating; Mental Depression; Moods; Motor; Mydriasis; Nature; Neurodegenerative Disorders; Neurosciences; Parkinson Disease; Participant; Patient Self-Report; Patients; Pattern; Peptide Signal Sequences; Performance; Pharmaceutical Preparations; Physiological; Preparation; Process; Psychological Factors; Psychophysiology; Pupil; Quality of life; Reaction Time; Reflex action; Research; Rewards; Sampling; Severities; Severity of illness; Signal Transduction; Staging; Stimulus; Symptoms; System; Testing; base; blink reflexes; design; emotional stimulus; experience; follow-up; indexing; motor disorder; neural circuit; neuropsychiatry; pleasure; public health relevance; response; sensory stimulus; vigilance

DESCRIPTION (provided by applicant): The overarching goal of the proposed project is to increase understanding of emotional processing in Parkinson's disease. Parkinson's disease is one of the most common neurodegenerative disorders of late life affecting 1-2% of people over the age of 65. It is caused by dopamine depletion with motor, cognitive, and emotional consequences. While advances have been made with respect to motor symptoms, emotional and neuropsychiatric changes (depression, apathy, anxiety) remain highly prevalent and can be the some of the most disturbing, disabling, and complex aspects of the disorder. Two recent studies of emotional responding from our group yielded conflicting results in non-demented Parkinson patients who were psychiatrically normal. One study found blunted emotional reactivity to aversive pictures, as indexed by the startle eye blink response (Bowers et al., 2006), while the other demonstrated normal reactivity as reflected by pupil dilation responses that were larger to emotional than neutral pictures (Dietz et al., 2010). One interpretation of these divergent findings is that pupil dilation and startle eye blink index different components of the emotion processing cascade, namely increased arousal/orienting (pupil) vs. priming of the defense circuitry (startle reflex). In light of these findings, the proposed study is designed to examine, in the same group of Parkinson patients, components of the emotion cascade from emotional arousal, heightened attention and vigilance, to mobilization for goal-directed behavior. To do so, non-demented and non-depressed Parkinson patients and controls will be tested on two tasks, one involving simple picture viewing and the other based on the "predator- prey" task of Low, Lang, Smith, and Bradley (2008). In the latter, cues that signal potential reward/loss or neutrality loom progressively closer until a final "strike-zone" where the participant is required to make a button press, and in target trials either to gain (monetary) reward or avoid a loss. Event-related potentials (LPP, P3), startle eye-blink, and motor reaction times will be used to index arousal/attention, vigilance, and modulated behavior during motivationally relevant and neutral task conditions. Based on known aberrations in neural circuitries affected by dopamine depletion, it is hypothesized that PD patients will have relatively preserved performance on indices of arousal/motivated attention early in the emotion processing cascade but will become increasingly aberrant as the prospect of reward/loss becomes imminent. If supported, findings from this study may suggest a framework for viewing motivational deficits in patients with Parkinson disease, including commonly occurring neuropsychiatric symptoms such as apathy. PUBLIC HEALTH RELEVANCE: Although Parkinson's disease is typically viewed as a motor disorder, it is a complex multi-system disorder that also causes significant emotional and mood changes including depression, apathy, and anxiety in up to 80% of patients. These non-motor changes are often the most disturbing, disabling, and complex aspects of the disorder affecting quality of life, cognitive decline, interpersonal relationships, and caregiver burden. The purpose of the proposed research is to better understand the nature of some of the emotional processing deficits in Parkinson disease by using contemporary emotion neuroscience paradigms with the ultimate hope of providing information leading to better treatment approaches for some of the emotional disturbances in Parkinson disease.

描述(由申请者提供)：建议项目的首要目标是增加对帕金森氏症情绪处理的了解。帕金森氏症是最常见的晚年神经退行性疾病之一，影响着1%-2%的65岁以上的人。它是由多巴胺耗尽引起的，会导致运动、认知和情感方面的后果。虽然在运动症状方面已经取得了进展，但情绪和神经精神变化(抑郁、冷漠、焦虑)仍然非常普遍，可能是该疾病最令人不安、最致残和最复杂的一些方面。最近来自我们小组的两项关于情绪反应的研究在精神正常的非痴呆帕金森患者中产生了相互矛盾的结果。一项研究发现，对厌恶图片的情绪反应迟钝，以惊吓眨眼反应为指标(Bowers等人，2006年)，而另一项研究显示正常反应，表现为对情绪图片的瞳孔放大反应大于中性图片(Dietz等人，2010年)。对这些不同发现的一种解释是，瞳孔放大和惊吓眨眼指示情绪处理级联的不同组成部分，即唤醒/定向(瞳孔)与防御回路(惊吓反射)的启动。根据这些发现，这项拟议的研究旨在检查同一组帕金森患者的情绪组成，从情绪唤醒、高度关注和警觉，到动员目标导向行为。为此，非痴呆和非抑郁的帕金森患者和对照组将接受两项任务的测试，一项涉及简单的图片观看，另一项基于Low，Lang，Smith和Bradley(2008)的“捕食者-猎物”任务。在后者中，暗示潜在的奖励/损失或中性的信号逐渐逼近，直到参与者被要求按下按钮的最终“击球区”，以及在目标试验中，要么获得(金钱)奖励，要么避免损失。事件相关电位(LPP，P3)、惊吓眨眼和运动反应时间将被用来指示在动机相关和中性任务条件下的唤醒/注意、警觉和调节行为。根据已知的受多巴胺耗竭影响的神经回路的异常，假设帕金森病患者在情绪处理级联反应的早期，在唤醒/动机注意指标上将具有相对保持的表现，但随着奖励/损失的前景变得迫在眉睫，将变得越来越异常。如果得到支持，这项研究的发现可能会为观察帕金森病患者的动机缺陷提供一个框架，包括常见的神经精神症状，如冷漠。 公共卫生相关性：尽管帕金森氏症通常被视为一种运动障碍，但它是一种复杂的多系统障碍，也会导致高达80%的患者出现显著的情绪和情绪变化，包括抑郁、冷漠和焦虑。这些非运动性变化往往是影响生活质量、认知能力下降、人际关系和照顾者负担的障碍中最令人不安、最令人残疾和最复杂的方面。这项拟议的研究的目的是通过使用当代情绪神经科学范式来更好地了解帕金森病一些情绪处理缺陷的性质，最终希望提供信息，从而为帕金森病的一些情绪障碍提供更好的治疗方法。