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Volumetric MRSI Evaluation of Traumatic Brain Injury

创伤性脑损伤的体积 MRSI 评估

基本信息

批准号：
8204443
负责人：
Andrew A. Maudsley
金额：
$ 33.52万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8204443
关键词：
Accounting Affect Age Anisotropy Blast Injuries Brain Brain Concussion Brain Injuries Brain region Choline Clinic Clinical assessments Closed head injuries Cognitive Craniocerebral Trauma Development Diffusion Magnetic Resonance Imaging Evaluation Exhibits Functional disorder Gray unit of radiation dose Head Headache Image Image Analysis Individual Injury Lobar Location Magnetic Resonance Imaging Maps Measurement Measures Membrane Metabolic Metabolic Marker Metabolism Methods Minor N-acetylaspartate Neuronal Dysfunction Neurons Normal Range Outcome Outcome Measure Patients Pattern Performance Post-Concussion Syndrome Post-Traumatic Headaches Protons Public Health Reaction Recovery of Function Relaxation Reporting Severities Signal Transduction Sports Symptoms Testing Time Tissues Traumatic Brain Injury Water base cognitive function expectation follow-up functional outcomes improved magnetic resonance spectroscopic imaging neuroimaging neuropsychological outcome forecast restoration spectroscopic imaging white matter

项目摘要

The primary aim of this project is to develop objective measures for evaluation of mild and moderate Traumatic Brain Injury (MTBI) using advanced MR neuroimaging methods. MTBI represents a major public health problem for which the current assessment measures are limited in their ability to quantify the severity of injury or to indicate possible outcomes. The pilot period of this project has demonstrated that Volumetric Magnetic Resonance Spectroscopic Imaging (MRSI) at 3 Tesla can detect widespread metabolic changes in the brain that correlate with the degree of injury, even for mild injury and in the absence of significant structural MRI findings. It is now proposed to extend this study to improve characterization of these changes and to evaluate the use MRSI and diffusion-weighted MRI measures for prognosis of functional outcomes following mild and moderate closed-head injury. Measurements will include N-Acetylaspartate and choline, metabolic markers known to be sensitive to neuronal dysfunction and membrane turnover, and Fractional Anisotropy, which reflects the degree of neuronal organization. Results will be correlated with findings from structural MRI, initial clinical assessments, and neuropsychological evaluation of functional outcomes at multiple time points after injury. A secondary aim of this study is to examine possible associations between post- concussive symptoms, which are debilitating and persistent consequences in a fraction of this patient group, and neuroimaging measures. A third aim is to optimize the quantitative and multiparametric neuroimaging measures to improve characterization of the spatial extent and the degree of metabolic consequences of the injury, and their associations with functional outcome measures. It is hypothesized that the improved sensitivity and spatial coverage of the proposed neuroimaging measures will improve characterization of mild and moderate injury.

这个项目的主要目的是制定客观的措施来评估轻度和使用先进的磁共振神经成像方法诊断中度创伤性脑损伤(MTBI)。MTBI 是一个重大的公共卫生问题，目前的评估措施是他们在量化伤害严重程度或表明可能的后果方面的能力有限。飞行员这个项目的周期已经证明了体积磁共振波谱 3特斯拉的磁共振成像(MRSI)可以检测到大脑中广泛存在的与损伤程度，即使是轻微损伤，在没有显著结构磁共振的情况下也是如此调查结果。现在建议扩展这项研究，以改进对这些变化的描述并评价磁共振成像和弥散加权成像对功能性脑梗塞预后的影响。轻、中度闭合性头部损伤的预后。衡量标准将包括 N-乙酰天冬氨酸和胆碱，已知的对神经元功能障碍敏感的代谢标志物和膜周转率，以及反映神经元程度的分数各向异性组织。结果将与结构MRI的结果相关联，初步临床多个时间点的功能结果评估和神经心理学评估受伤后。这项研究的第二个目的是检查后两者之间可能的联系脑震荡症状，其中一小部分会使人虚弱并持续产生后果患者组，并进行神经影像检查。第三个目标是优化数量和多参数神经成像措施，以改善空间范围和损伤的代谢后果的程度及其与功能的关系结果衡量标准。据假设，提高的敏感度和空间覆盖率建议的神经成像措施将改善轻、中度损伤的特征。