Development and Maintenance of Software for MR Spectroscopic Imaging

磁共振波谱成像软件的开发和维护

• 批准号: 8735144
• 负责人: Andrew A. Maudsley
• 金额: $ 24.25万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735144
• 关键词: Address; Advertising; Biomedical Research; Brain; Brain Mapping; Clinical; Clinical Research; Code; Computer software; Data; Data Analyses; Data Set; Databases; Detection; Development; Diagnostic; Documentation; Educational Materials; Environment; Evaluation; Excision; Future; Goals; Image; Imaging technology; Libraries; Licensing; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maintenance; Manufacturer Name; Maps; Measurement; Metabolic; Methods; Modality; Modification; Multiparametric Analysis; Nervous System Trauma; Operating System; Performance; Physiologic pulse; Procedures; Process; Protons; Pythons; Research; Research Personnel; Residual state; Resolution; Running; Sampling; Site; Spectrum Analysis; Speed; Staging; Study Subject; Support System; Surface; System; Temperature; Time; Tissues; Validation; Vendor; Water; Writing; bioimaging; brain volume; clinical application; computerized data processing; data acquisition; data format; image processing; improved; in vivo; innovation; instrument; instrumentation; magnetic resonance spectroscopic imaging; multicore processor; nervous system disorder; novel; organizational structure; outreach; programs; public health relevance; research study; software development; software systems; spectroscopic imaging; tool; web site

DESCRIPTION (provided by applicant): The MIDAS (Metabolic Imaging Data Analysis System) software package provides comprehensive and unique functionality for processing, display, and analysis of MR Spectroscopic imaging (MRSI) data, and includes close integration with information available from structural and other parametric MRI modalities. This system supports a volumetric echo- planar spectroscopic imaging (EPSI) acquisition that provides high-resolution images of a wide extent of the brain, including cortical surface regions, which has been implemented on MR instruments from three major manufacturers. The EPSI and MIDAS software have been distributed to multiple sites worldwide. Under four specific aims this project will maintain and develop new functionality for these packages. Aim 1 will add new spectroscopy and image processing functions, which will include capabilities for volumetric mapping of brain temperature, metabolite T2, and parametric changes between studies. Aim 2 will improve performance, software organization, and maintainability by refactoring historically diverse pieces of code under a common programming environment. Aim 3 will support the EPSI acquisition through future system upgrades and add new capabilities to the data acquisition methods. Aim 4 will continue development of user documentation, educational materials, and the project web site, and make available data acquired under previous projects. Through these aims this project will provide continued support and development for a highly innovative suite of functions that facilitate clinical and basic biomedical imaging research studies using MRI and MRSI.

描述（由申请人提供）：MIDAS（代谢成像数据分析系统）软件包为MR光谱成像（MRSI）数据的处理、显示和分析提供了全面和独特的功能，并包括与结构和其他参数MRI模态提供的信息的紧密集成。该系统支持体积回波平面光谱成像（EPSI）采集，可提供大范围大脑（包括皮质表面区域）的高分辨率图像，已在三家主要制造商的MR仪器上实现。EPSI和MIDAS软件已分发到世界各地的多个地点。根据四个具体目标，该项目将维护和开发这些软件包的新功能。目标1将增加新的光谱学和图像处理功能，包括脑温度、代谢物T2和研究之间参数变化的体积映射功能。目标2将通过在一个公共的编程环境下重构历史上不同的代码片段来提高性能、软件组织和可维护性。目标3将通过未来的系统升级支持EPSI采集，并为数据采集方法增加新的功能。目标4将继续编制用户文件、教材和项目网站，并提供在以前项目下获得的数据。通过这些目标，该项目将为一套高度创新的功能提供持续的支持和开发，这些功能将促进使用MRI和MRSI的临床和基础生物医学成像研究。