Multiparametric Volumetric MR Characterization of Intracranial Lesions

描述(申请人提供)：MRI采集映射反映组织新陈代谢和生理的参数提供了相当大的潜力来提高脑内病变的诊断成像研究的产量，包括更好地表征脑内病变 病变类型和更高的敏感度，以检测由于肿瘤渗透或治疗反应而导致的组织功能的细微变化。一种特别令人感兴趣的脑癌表征方法是磁共振光谱成像；然而，目前商业仪器上提供的技术没有利用技术和数据处理方面的最新发展，这种成像模式的新实现的潜力尚未得到充分评估。还需要额外的努力来确定用于脑损伤诊断研究的结构和参数成像方法的最佳选择。这项研究将开发一种多参数磁共振成像协议的有效实施，并向其他用户提供，该协议包括体积“全脑”和高空间分辨率磁共振光谱成像方法，该方法将被集成到西门子医疗系统公司的3T磁共振成像设备上。MRI协议将包括一种新的体积和校准的动脉自旋标记采集和扩散加权成像。这种先进的成像方式的结合将为诊断颅内肿块的MRI研究提供最佳的灵敏度和空间覆盖率。这种多参数和定量的MRI方案的诊断效果将在门诊环境下对广泛的脑部病理研究进行评估。研究将调查 结构成像和参数成像协议的相对价值，包括对图像质量、诊断准确性以及评分者间和评分者内部可靠性的评估。为此目的而获得的数据然后将用于开发和评估计算机辅助诊断方法，该方法使用多参数、体积和定量图像数据的基于体素的组织分类。

DESCRIPTION (provided by applicant): MRI acquisitions that map parameters reflecting tissue metabolism and physiology offer considerable potential for improving the yield of diagnostic imaging studies of intra-cranial brain lesions, including better characterization of the type of lesion and increased sensitivity to detect subtle changes of tissue function due to tumor infiltration or response to therapy. A method of particular interest for characterization of brain cancers is MR spectroscopic imaging; however, the techniques currently provided on commercial instruments do not take advantage of recent development in technology and data processing and the potential for new implementations of this imaging modality has yet to be fully evaluated. Additional effort is required to determine the optimal selection of structural and parametric imaging methods for diagnostic studies of brain lesions. This study will develop and make available to other users an efficient implementation of a multiparametric MRI protocol that includes a volumetric "whole-brain" and high spatial resolution MR spectroscopic imaging method that will be integrated onto 3T MRI instruments from Siemens Medical Systems. The MRI protocol will include a novel volumetric and calibrated arterial spin labeling acquisition and diffusion weighted imaging. This combination of advanced imaging modalities will provide optimal sensitivity and spatial coverage for diagnostic MRI studies of intra-cranial masses. The diagnostic efficacy of this multi-parametric and quantitative MRI protocol will then be evaluated for studies of a wide range of brain pathologies in an outpatient setting. Studies will investigate the relative value of structural imaging and parametric imaging protocols, including evaluations of image quality, diagnostic accuracy, and inter- and intra-rater reliability. The data acquired fo this aim will then be used to develop and evaluate computer-aided diagnostic methods using voxel-based tissue classification of the multiparametric, volumetric, and quantitative image data.