Partnership for MR Spectroscopic Imaging Data Processing

描述(申请人提供)：用1H磁共振波谱成像(MRSI)测量组织代谢物分布提供了一种灵敏的诊断神经成像方式；然而，它在临床环境中仍未得到充分利用。限制这些技术更广泛使用的一个要求是需要全面的数据处理程序，它最好地广泛利用先前的信息，包括来自MRI的组织和形态分析以及正常代谢物分布的知识。在前一个资助期，该项目开发了一个综合软件包，提供全面和自动化的磁共振成像和磁共振成像处理，包括信号归一化和空间转换，从而能够形成作为采集、空间和受试者参数的函数的磁共振观察到的人体代谢物值的参考图像数据库。该数据库能够绘制大脑代谢物分布图，并为分析个别患者研究提供有价值的规范信息。在本项目期间，将进一步开发这些处理方法，并将其与三家主要制造商在磁共振仪器上实施的标准化MRSI采集协议相结合，并将扩展代谢物数据库，以支持开发的采集协议。因此，该项目将开发标准化的1H MRSI方案，包括跨站点和长期验证和质量控制，从而最大限度地发挥MRSI对临床研究的影响，并促进多站点定量代谢成像研究。这些标准化代谢神经成像方案的有效性将通过在临床研究地点安装交钥匙系统进行评估，在那里将开发性能指标并获取数据，以测试标准化MRSI方法检测个别受试者代谢变化的敏感性。所有开发成果将免费提供给参与临床诊断成像应用MRSI的研究人员。该项目的生物工程重点领域包括信号和图像处理、磁共振神经成像序列开发、多参数图像分析方法和网络图像数据库。合作地点是迈阿密大学(领先机构)、加州大学洛杉矶分校、约翰·霍普金斯大学、斯坦福大学和杜克大学。这一进展将提高使用磁共振波谱获得的诊断神经成像信息的质量；通过共享来自正常受试者的数据来节省成本；建立标准化的代谢成像方法；以及绘制代谢物在人脑中的分布图。

DESCRIPTION (provided by applicant): Measurement of tissue metabolite distributions by 1H MR Spectroscopic Imaging (MRSI) provides a sensitive diagnostic neuroimaging modality; however, it remains underutilized in the clinical setting. One requirement that has limited a wider use of these techniques is the need for comprehensive data processing procedures, which optimally make extensive use of prior information, including tissue and morphological analysis from MRI and knowledge of normal metabolite distributions. In the previous funding period this project has developed an integrated software package that provides comprehensive and automated MRI and MRSI processing that includes signal normalization and spatial transformation, thereby enabling formation of a reference image database of MR-observed human metabolite values as a function of acquisition, spatial, and subject parameters. This database enables mapping of brain metabolite distributions and provides valuable normative information for analysis of individual patient studies. In this project period these processing methods will be further developed and integrated with standardized MRSI acquisition protocols implemented on MR instruments from three major manufacturers, and the metabolite database will be expanded to support the developed acquisition protocols. This project will therefore develop standardized 1H MRSI protocols, including cross-site and long-term validation and quality control, that will maximize the impact of MRSI for clinical studies and facilitate multi-site quantitative metabolic imaging studies. The effectiveness of these standardized metabolic neuroimaging protocols will be evaluated by installing a turnkey system at a clinical research site where performance metrics will be developed and data acquired to test the sensitivity of the standardized MRSI methods for detection of metabolic changes in individual subjects. All developments will be made freely available to researchers involved in the application of MRSI for clinical diagnostic imaging. The bioengineering focus areas of this project include signal and image processing, MR neuroimaging sequence development, multiparametric image analysis methods, and networked image databases. The partnership sites are the University of Miami (leading institution), University of California Los Angeles, Johns Hopkins University, Stanford University, and Duke University. This development will improve the quality of the diagnostic neuroimaging information obtained using MR spectroscopy; provide cost savings by sharing data from normal subject; establish standardized metabolic imaging methods; and map metabolite distributions in human brain.