Multi-faceted Approach Modeling ACL Injury Mechanisms
多方位方法模拟 ACL 损伤机制
基本信息
- 批准号:8284418
- 负责人:
- 金额:$ 41.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-05-15 至 2013-09-15
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAnteriorAnterior Cruciate LigamentAthleticBiomechanicsComputersContusionsCoupledDataDegenerative polyarthritisDevelopmentDiagnosisElementsFailureFemaleHealth BenefitHumanInjuryKineticsKneeKnee OsteoarthritisKnee jointLeadLifeLigamentsLower ExtremityMagnetic Resonance ImagingMechanicsMedialMethodsModelingMotionOperative Surgical ProceduresOutcome StudyOutputPatientsPatternPopulationPreventionPrevention programProtocols documentationPublic HealthReactionRehabilitation therapyRelative (related person)ReportingRiskRotationSex CharacteristicsSimulateSportsStressSurfaceTechniquesTestingTimeTorqueTranslationsValidationanterior cruciate ligament rupturearticular cartilagebonecareerclinically significantcollateral ligamentdesigndisabilityeffective interventionhigh riskin vivoinjuredinjury preventioninsightjoint loadingligament injurymalemathematical modelpressurepreventprogramsprospectiveresponserestraintsimulationtool
项目摘要
PROJECT SUMMARY
The anterior cruciate ligament (ACL) is one of the most commonly injured ligaments of
the knee, with female athletes sustaining ACL injuries at a 2-8 fold greater rate
compared to male athletes. An ACL injury can be devastating and significantly increases
the athlete's risk for osteoarthritis long term. While many advances have been made in
terms of surgical and rehabilitation treatments for ACL injured patients, long term
outcome studies show that these patients are at a high risk for developing knee
osteoarthritis 10-15 years after ACL injury regardless of the treatment. Currently, the
mechanism of non-contact ACL injury is not well understood. In order to design
successful ACL injury prevention programs and address the high rates of ACL injuries in
the female athlete population, a better understanding of the non-contact ACL injury
mechanism must be established. Both biomechanical data and video analyses indicate
that increased abduction loads in the lower extremities may be associated with
increased ACL strain and risk of injury. However, the medial collateral ligament (MCL) is
considered to be the primary restraint against abduction stress in the knee joint.
Clinicians and biomechanists are unable to explain why ACL ruptures without MCL
injuries are significantly more common than combined ACL/MCL injuries. We
hypothesize that coupled abduction and anterior knee joint loads near full knee
extension will lead to disproportional increases in ACL strain relative to MCL strain and
lead to ACL failure loads without concomitant MCL failure loads in female athletes. We
propose to use a unique blend of the current methods used to investigate ACL injury
mechanisms in order to gain an in depth understanding of knee ligament biomechanics
during high knee loading conditions. Specifically, we aim to determine the mechanical
responses of the ACL and MCL to loads using cadaveric testing, computer mathematical
modeling, and three-dimensional motion analysis. Identifying ACL injury mechanisms
may help us develop ACL injury prevention programs that would allow many athletes to
receive the health benefits of sports participation and avoid the long term sequelae of
disability associated with knee osteoarthritis.
项目概要
前十字韧带(ACL)是最常见损伤的韧带之一
膝盖,女性运动员 ACL 受伤的几率是女性运动员的 2-8 倍
与男运动员相比。 ACL 损伤可能是毁灭性的,并且会显着增加
运动员长期患骨关节炎的风险。虽然已经取得了许多进步
ACL 损伤患者的长期手术和康复治疗
结果研究表明这些患者患膝关节的风险很高
无论接受何种治疗,ACL 损伤后 10-15 年都会出现骨关节炎。目前,
非接触性 ACL 损伤的机制尚不清楚。为了设计
成功的 ACL 损伤预防计划并解决了 ACL 损伤的高发生率
女性运动员群体,更好地了解非接触性 ACL 损伤
必须建立机制。生物力学数据和视频分析都表明
下肢外展负荷的增加可能与
增加 ACL 应变和受伤风险。然而,内侧副韧带(MCL)
被认为是膝关节外展应力的主要约束。
临床医生和生物力学学家无法解释为什么 ACL 会在没有 MCL 的情况下破裂
损伤比 ACL/MCL 联合损伤更为常见。我们
假设在全膝附近耦合外展和前膝关节载荷
延伸将导致 ACL 应变相对于 MCL 应变不成比例地增加,并且
导致女性运动员出现 ACL 失效负荷,但没有伴随 MCL 失效负荷。我们
建议使用当前用于研究 ACL 损伤的方法的独特组合
机制,以便深入了解膝关节韧带生物力学
在膝关节高负荷条件下。具体来说,我们的目标是确定机械
使用尸体测试、计算机数学来评估 ACL 和 MCL 对负载的响应
建模和三维运动分析。识别 ACL 损伤机制
可能会帮助我们制定 ACL 损伤预防计划,使许多运动员能够
获得参加体育运动的健康益处并避免长期后遗症
与膝骨关节炎相关的残疾。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Timothy E Hewett其他文献
ACL graft metabolic activity assessed by 18FDG PET-MRI.
通过 18FDG PET-MRI 评估 ACL 移植物代谢活性。
- DOI:
10.1016/j.knee.2017.04.008 - 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Robert A Magnussen;K. Binzel;Jun Zhang;Wen;Melanie U Knopp;David C Flanigan;Timothy E Hewett;Christopher C Kaeding;Michael V Knopp - 通讯作者:
Michael V Knopp
Timothy E Hewett的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Timothy E Hewett', 18)}}的其他基金
Multi-faceted Approach Modeling ACL Injury Mechanisms
多方位方法模拟 ACL 损伤机制
- 批准号:
7846129 - 财政年份:2009
- 资助金额:
$ 41.7万 - 项目类别:
Multi-faceted Approach to Modeling ACL Injury Mechanisms
ACL 损伤机制建模的多方面方法
- 批准号:
8651985 - 财政年份:2009
- 资助金额:
$ 41.7万 - 项目类别:
Multi-faceted Approach to Modeling ACL Injury Mechanisms
ACL 损伤机制建模的多方面方法
- 批准号:
8911250 - 财政年份:2009
- 资助金额:
$ 41.7万 - 项目类别:
Multi-faceted Approach to Modeling ACL Injury Mechanisms
ACL 损伤机制建模的多方面方法
- 批准号:
8735607 - 财政年份:2009
- 资助金额:
$ 41.7万 - 项目类别:
Multi-faceted Approach Modeling ACL Injury Mechanisms
多方位方法模拟 ACL 损伤机制
- 批准号:
7654283 - 财政年份:2009
- 资助金额:
$ 41.7万 - 项目类别:
Multi-faceted Approach Modeling ACL Injury Mechanisms
多方位方法模拟 ACL 损伤机制
- 批准号:
8069179 - 财政年份:2009
- 资助金额:
$ 41.7万 - 项目类别:
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
针对女运动员 ACL 负荷机制的神经肌肉干预
- 批准号:
8123294 - 财政年份:2008
- 资助金额:
$ 41.7万 - 项目类别:
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
针对女运动员 ACL 负荷机制的神经肌肉干预
- 批准号:
7665088 - 财政年份:2008
- 资助金额:
$ 41.7万 - 项目类别:
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
针对女运动员 ACL 负荷机制的神经肌肉干预
- 批准号:
8309809 - 财政年份:2008
- 资助金额:
$ 41.7万 - 项目类别:
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
针对女运动员 ACL 负荷机制的神经肌肉干预
- 批准号:
7528929 - 财政年份:2008
- 资助金额:
$ 41.7万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 41.7万 - 项目类别:
Research Grant