Treatment of Periodontitis and Inflammatory Changes in Diabetes

描述(由申请者提供)：指导患者导向研究职业发展奖(K23)将为首席研究人员提供75%的保护时间，以发展牙科医学中以患者为导向的研究的设计、实施和分析方面的独立研究专业知识。拟议的职业发展计划基于应聘者的兴趣以及以前在牙周学、系统性疾病和临床调查方面的培训和经验。这项五年计划旨在使候选人获得波士顿大学医学院临床研究领域的文学硕士学位，并为她提供在临床研究领域开展独立研究计划的经验。职业发展计划建议在拟议的五年奖励期内进行初步的教学工作，以及涉及糖尿病和牙周感染的前瞻性干预性临床研究的监督研究经验。正式的临床调查培训和监督研究计划将为候选人提供必要的准备，以实施她提出的研究项目，该项目涉及在波士顿大学医学中心和BostonNet健康中心对一组糖尿病患者进行牙周健康干预研究。候选人将由经验丰富的调查人员指导，这些调查人员在指导研究实习生的工作方面有成功的记录。这项K23计划将充分利用积极的研究合作，并为候选人提供广泛的接触以患者为导向的研究。反过来，这些现有的以患者为导向的研究项目，由美国国立卫生研究院、企业和基金会赞助商资助，将受益于候选人参与这些项目的能力。首席调查员将有机会在牙周健康决定因素和全身疾病以及生活质量结果领域的现有研究项目的基础上再接再厉，特别是研究牙周疾病和糖尿病的关系的临床干预性研究，特别是牙周治疗对控制糖尿病并发症的影响。

DESCRIPTION (provided by applicant): The Mentored Patient-Oriented Research Career Development Award (K23) will provide protected time, at 75%, for the principal investigator to develop independent research expertise in the design, conduct, and analysis of patient- oriented research in dental medicine. The proposed career development plan basis on the candidate's interests and previous training and experience in periodontology and systemic diseases and clinical investigations. The five-year plan is designed to lead to the candidate receiving the degree of Master of Arts, in the area of Clinical Investigations, from the Boston University School of Medicine and to provide her with experience of conducting independent research program in the field of clinical research. The career development plan proposes an initial period of didactic work, together with a supervised research experience involving a prospective, interventional clinical research study of diabetes and periodontal infections, in the proposed five-year award period. The formal training in clinical investigation and the supervised research program will provide the candidate with the preparation needed to carry out her proposed research project involving a periodontal health intervention study in a cohort of patients with diabetes being followed at Boston University Medical Center and BostonNet Health Centers. The candidate will be mentored by experienced investigators who have a successful track record of guiding the work of research trainees. This K23 program will take a full advantage of active research collaborations, and provide the candidate with a broad exposure to patient-oriented research. In turn, these existing patient-oriented research projects, funded by the NIH, and corporate and foundation sponsors, will benefit by the ability to involve the candidate in these programs. The principal investigator will have the opportunity to build on existing research projects in the area of periodontal health determinants and systemic disease and quality of life outcomes, with a special focus on the study of clinical interventional study of the relationship of periodontal diseases and diabetes and especially the impact of periodontal treatment on the control of the diabetic complications.